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PAPOLB poly(A) polymerase beta [ Homo sapiens (human) ]

Gene ID: 56903, updated on 2-Nov-2024

Summary

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Official Symbol
PAPOLBprovided by HGNC
Official Full Name
poly(A) polymerase betaprovided by HGNC
Primary source
HGNC:HGNC:15970
See related
Ensembl:ENSG00000218823 MIM:607436; AllianceGenome:HGNC:15970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPT; TPAP
Summary
Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing and mRNA processing. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See PAPOLB in Genome Data Viewer
Location:
7p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (4857738..4862030, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (4974940..4979232, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (4897369..4901661, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4832559-4833233 Neighboring gene adaptor related protein complex 5 subunit zeta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17904 Neighboring gene microRNA 4656 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4847903-4848404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4848405-4848904 Neighboring gene Rap associating with DIL domain Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4878225-4878893 Neighboring gene small nucleolar RNA, C/D box 165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4900904-4901516 Neighboring gene ribosomal protein L22 pseudogene 16 Neighboring gene Sharpr-MPRA regulatory region 4159 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4922762-4923449 Neighboring gene monocyte to macrophage differentiation associated 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Testis-specific expression of an intronless gene encoding a human poly(A) polymerase. Le YJ, et al. Mol Cells, 2001 Jun 30. PMID 11459229
  2. An intronless gene encoding a poly(A) polymerase is specifically expressed in testis. Lee YJ, et al. FEBS Lett, 2000 Dec 29. PMID 11150526
  3. Tat-dependent occlusion of the HIV poly(A) site. Weichs an der Glon C, et al. EMBO J, 1993 May. PMID 8491200, Free PMC Article
  4. Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Wheat A, et al. Proc Natl Acad Sci U S A, 2021 Aug 10. PMID 34349018, Free PMC Article
  5. Panorama of ancient metazoan macromolecular complexes. Wan C, et al. Nature, 2015 Sep 17. PMID 26344197, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
poly(A) polymerase beta
Names
PAP-beta
poly(A) polymerase beta (testis specific)
polynucleotide adenylyltransferase beta
testis-specific poly(A) polymerase
NP_064529.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020144.5 → NP_064529.4  poly(A) polymerase beta

    See identical proteins and their annotated locations for NP_064529.4

    Status: VALIDATED

    Source sequence(s)
    AC092610, AF218840, BC036653
    Consensus CDS
    CCDS78202.1
    UniProtKB/Swiss-Prot
    Q75LH1, Q8NE14, Q9NRJ5
    UniProtKB/TrEMBL
    A0ZTA0, A4D1Z6
    Related
    ENSP00000384700.2, ENST00000404991.2
    Conserved Domains (3) summary
    PTZ00418
    Location:21 → 569
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:367 → 496
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 364
    PAP_central; Poly(A) polymerase central domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    4857738..4862030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    4974940..4979232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRJ5.2 GenPept UniProtKB/Swiss-Prot:Q9NRJ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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