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MAP3K7CL MAP3K7 C-terminal like [ Homo sapiens (human) ]

Gene ID: 56911, updated on 5-Mar-2024

Summary

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Official Symbol
MAP3K7CLprovided by HGNC
Official Full Name
MAP3K7 C-terminal likeprovided by HGNC
Primary source
HGNC:HGNC:16457
See related
Ensembl:ENSG00000156265 MIM:611110; AllianceGenome:HGNC:16457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAKL; TAK1L; TAKL-1; TAKL-2; TAKL-4; C21orf7; HC21ORF7
Summary
Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 4.1), prostate (RPKM 2.4) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
21q21.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (29077114..29175887)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (27440554..27542501)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (30449435..30548208)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18328 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:30416252-30416450 Neighboring gene ubiquitin specific peptidase 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18330 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:30445041-30445952 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:30445953-30446864 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:30447741-30448940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18333 Neighboring gene chaperonin containing TCP1 subunit 8 Neighboring gene Sharpr-MPRA regulatory region 4059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13237 Neighboring gene NANOG hESC enhancer GRCh37_chr21:30506062-30506608 Neighboring gene ribosomal protein L12 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 14833 Neighboring gene uncharacterized LOC105372767 Neighboring gene small nucleolar RNA U3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18341 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:30568347-30569546 Neighboring gene long intergenic non-protein coding RNA 189 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel human TGF-beta activated kinase-like gene. Li J, et al. Biochem Genet, 2004 Apr. PMID 15168726
  2. Genome-wide identification of lncRNAs and mRNAs differentially expressed in human vascular smooth muscle cells stimulated by high phosphorus. Bao S, et al. Ren Fail, 2020 Nov. PMID 32401115, Free PMC Article
  3. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. Reymond A, et al. Genomics, 2001 Nov. PMID 11707072
  4. Genome-wide association scan of dental caries in the permanent dentition. Wang X, et al. BMC Oral Health, 2012 Dec 21. PMID 23259602, Free PMC Article
  5. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide identification of lncRNAs and mRNAs differentially expressed in human vascular smooth muscle cells stimulated by high phosphorus.
    Title: Genome-wide identification of lncRNAs and mRNAs differentially expressed in human vascular smooth muscle cells stimulated by high phosphorus.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
MAP3K7 C-terminal-like protein
Names
TAK1-like protein 1
TAK1-like protein 2
TAK1-like protein 4
TGF-beta activated kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286617.2 → NP_001273546.1  MAP3K7 C-terminal-like protein isoform 2

    See identical proteins and their annotated locations for NP_001273546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks 2 exons in the 5' region and contains 2 additional exons, which result in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
    Source sequence(s)
    AF129075, AF269162, EF219157
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    D3DSE0, P57077, Q8TCL9
    UniProtKB/TrEMBL
    B0EVZ8
    Related
    ENSP00000382817.2, ENST00000399935.6
    Conserved Domains (1) summary
    TIGR04211
    Location:39 → 142
    SH3_and_anchor; SH3 domain protein

  2. NM_001286618.2 → NP_001273547.1  MAP3K7 C-terminal-like protein isoform 2

    See identical proteins and their annotated locations for NP_001273547.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks 2 exons in the 5' region and contains an additional exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
    Source sequence(s)
    AF129075, AF269163, EF219157
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    D3DSE0, P57077, Q8TCL9
    UniProtKB/TrEMBL
    B0EVZ8
    Related
    ENSP00000382816.1, ENST00000399934.5
    Conserved Domains (1) summary
    TIGR04211
    Location:39 → 142
    SH3_and_anchor; SH3 domain protein

  3. NM_001286619.2 → NP_001273548.1  MAP3K7 C-terminal-like protein isoform 2

    See identical proteins and their annotated locations for NP_001273548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' end and contains 3 additional exons, which result in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
    Source sequence(s)
    AF269162, AK122780, AK294287, BG566433
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    D3DSE0, P57077, Q8TCL9
    UniProtKB/TrEMBL
    B0EVZ8
    Related
    ENSP00000345777.4, ENST00000339024.8
    Conserved Domains (1) summary
    TIGR04211
    Location:39 → 142
    SH3_and_anchor; SH3 domain protein

  4. NM_001286620.2 → NP_001273549.1  MAP3K7 C-terminal-like protein isoform 2

    See identical proteins and their annotated locations for NP_001273549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains alternate 5' end exons that result in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
    Source sequence(s)
    AF269161, BC008567
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    D3DSE0, P57077, Q8TCL9
    UniProtKB/TrEMBL
    B0EVZ8
    Related
    ENSP00000382812.1, ENST00000399928.6
    Conserved Domains (1) summary
    TIGR04211
    Location:39 → 142
    SH3_and_anchor; SH3 domain protein

  5. NM_001286622.2 → NP_001273551.1  MAP3K7 C-terminal-like protein isoform 3

    See identical proteins and their annotated locations for NP_001273551.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks 2 exons in the 5' region and contains an additional exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (3) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF129075, AF269161, AK294287, EF219157
    Consensus CDS
    CCDS74775.1
    UniProtKB/TrEMBL
    B4DFW0
    Related
    ENSP00000437846.1, ENST00000545939.5
    Conserved Domains (1) summary
    cl09232
    Location:54 → 124
    YqaJ; YqaJ-like viral recombinase domain

  6. NM_001286623.2 → NP_001273552.1  MAP3K7 C-terminal-like protein isoform 4

    See identical proteins and their annotated locations for NP_001273552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks a non-coding exon in the 5' region and contains an alternate 3' terminal exon compared to variant 1. The resulting shorter isoform (4) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF129075, EF219157
    UniProtKB/TrEMBL
    B0EVZ6
    Related
    ENSP00000518225.1, ENST00000710354.1

  7. NM_001286624.2 → NP_001273553.1  MAP3K7 C-terminal-like protein isoform 5

    See identical proteins and their annotated locations for NP_001273553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks many exons from the 5' and mid region and contains an alternate 5' terminal exon, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The resulting isoform (5) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF269161, AK309998, BI911525
    UniProtKB/TrEMBL
    B0EVZ7

  8. NM_001286634.2 → NP_001273563.1  MAP3K7 C-terminal-like protein isoform 1

    See identical proteins and their annotated locations for NP_001273563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks 2 exons in the 5' non-coding region compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF129075, AF269161, EF219157
    Consensus CDS
    CCDS13584.1
    UniProtKB/Swiss-Prot
    P57077
    UniProtKB/TrEMBL
    B0EVZ6
    Related
    ENSP00000343212.4, ENST00000341618.8
    Conserved Domains (1) summary
    TIGR04211
    Location:118 → 242
    SH3_and_anchor; SH3 domain protein

  9. NM_001371369.1 → NP_001358298.1  MAP3K7 C-terminal-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075
    Consensus CDS
    CCDS13584.1
    Conserved Domains (1) summary
    TIGR04211
    Location:118 → 242
    SH3_and_anchor; SH3 domain protein

  10. NM_001371370.1 → NP_001358299.1  MAP3K7 C-terminal-like protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075
    Conserved Domains (1) summary
    TIGR04211
    Location:100 → 203
    SH3_and_anchor; SH3 domain protein

  11. NM_001371371.1 → NP_001358300.1  MAP3K7 C-terminal-like protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075, BP290461, DA021298
    Conserved Domains (1) summary
    TIGR04211
    Location:58 → 161
    SH3_and_anchor; SH3 domain protein

  12. NM_001371372.1 → NP_001358301.1  MAP3K7 C-terminal-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF124730, EF219159
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    D3DSE0, P57077, Q8TCL9
    UniProtKB/TrEMBL
    B0EVZ8
    Related
    ENSP00000382809.1, ENST00000399925.5
    Conserved Domains (1) summary
    TIGR04211
    Location:39 → 142
    SH3_and_anchor; SH3 domain protein

  13. NM_001371373.1 → NP_001358302.1  MAP3K7 C-terminal-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075, CB963708
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    D3DSE0, P57077, Q8TCL9
    UniProtKB/TrEMBL
    B0EVZ8
    Related
    ENSP00000382810.1, ENST00000399926.5
    Conserved Domains (1) summary
    TIGR04211
    Location:39 → 142
    SH3_and_anchor; SH3 domain protein

  14. NM_001371374.1 → NP_001358303.1  MAP3K7 C-terminal-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075
    Consensus CDS
    CCDS68182.1
    UniProtKB/Swiss-Prot
    D3DSE0, P57077, Q8TCL9
    UniProtKB/TrEMBL
    B0EVZ8
    Conserved Domains (1) summary
    TIGR04211
    Location:39 → 142
    SH3_and_anchor; SH3 domain protein

  15. NM_001371376.1 → NP_001358305.1  MAP3K7 C-terminal-like protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AF124730, AF129075, EF219158
    UniProtKB/TrEMBL
    B0EVZ7

  16. NM_020152.4 → NP_064537.1  MAP3K7 C-terminal-like protein isoform 1

    See identical proteins and their annotated locations for NP_064537.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF129075, AF269161, AY171599, EF219157
    Consensus CDS
    CCDS13584.1
    UniProtKB/Swiss-Prot
    P57077
    UniProtKB/TrEMBL
    B0EVZ6
    Related
    ENSP00000382828.2, ENST00000399947.6
    Conserved Domains (1) summary
    TIGR04211
    Location:118 → 242
    SH3_and_anchor; SH3 domain protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    29077114..29175887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440930.1 → XP_047296886.1  MAP3K7 C-terminal-like protein isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791813.1 Reference GRCh38.p14 PATCHES

    Range
    167848..269778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    27440554..27542501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57077.2 GenPept UniProtKB/Swiss-Prot:P57077

Gene LinkOut

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