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CEACAM19 CEA cell adhesion molecule 19 [ Homo sapiens (human) ]

Gene ID: 56971, updated on 2-Nov-2024

Summary

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Official Symbol
CEACAM19provided by HGNC
Official Full Name
CEA cell adhesion molecule 19provided by HGNC
Primary source
HGNC:HGNC:31951
See related
Ensembl:ENSG00000186567 MIM:606691; AllianceGenome:HGNC:31951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEAL1; CEACM19
Summary
Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in skin (RPKM 5.4), testis (RPKM 2.3) and 24 other tissues See more
Orthologs
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Genomic context

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See CEACAM19 in Genome Data Viewer
Location:
19q13.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44665860..44684355)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47490642..47509104)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45169128..45187627)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45118285-45118786 Neighboring gene immunoglobulin superfamily member 23 Neighboring gene Sharpr-MPRA regulatory region 2639 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14764 Neighboring gene MPRA-validated peak3503 silencer Neighboring gene PVR cell adhesion molecule Neighboring gene microRNA 4531 Neighboring gene uncharacterized LOC107985306 Neighboring gene Sharpr-MPRA regulatory region 3873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45192479-45192980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45192981-45193480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45199988-45200593 Neighboring gene CEACAM16, CEACAM19 and PVR antisense RNA 1 Neighboring gene CEA cell adhesion molecule 16, tectorial membrane component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and expression analysis of novel splice variants of the human carcinoembryonic antigen-related cell adhesion molecule 19 (CEACAM19) gene using a high-throughput sequencing approach. Zisi Z, et al. Genomics, 2020 Nov. PMID 32659328
  2. High expression of CEACAM19, a new member of carcinoembryonic antigen gene family, in patients with breast cancer. Estiar MA, et al. Clin Exp Med, 2017 Nov. PMID 27909883
  3. The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression. Michaelidou K, et al. Int J Oncol, 2013 May. PMID 23525470
  4. Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors. Scorilas A, et al. Gene, 2003 May 22. PMID 12801635
  5. Knockdown of CEACAM19 suppresses human gastric cancer through inhibition of PI3K/Akt and NF-κB. Zhao H, et al. Surg Oncol, 2018 Sep. PMID 30217308

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and expression analysis of novel splice variants of the human carcinoembryonic antigen-related cell adhesion molecule 19 (CEACAM19) gene using a high-throughput sequencing approach.
    Title: Identification and expression analysis of novel splice variants of the human carcinoembryonic antigen-related cell adhesion molecule 19 (CEACAM19) gene using a high-throughput sequencing approach.
  2. High CEACAM19 expression is associated with gastric cancer.
    Title: Knockdown of CEACAM19 suppresses human gastric cancer through inhibition of PI3K/Akt and NF-κB.
  3. In conclusion, CEACAM19 showed high expression in tumor samples compared to normal mammary tissue.
    Title: High expression of CEACAM19, a new member of carcinoembryonic antigen gene family, in patients with breast cancer.
  4. Our results suggest that CEACAM19 mRNA expression represents a promising, novel and clinically useful tissue biomarker for breast cancer management.
    Title: The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105097

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 19
Names
carcinoembryonic antigen related cell adhesion molecule 19
carcinoembryonic antigen-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127893.3 → NP_001121365.1  carcinoembryonic antigen-related cell adhesion molecule 19 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001121365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter protein (isoform 1).
    Source sequence(s)
    AC243964
    Consensus CDS
    CCDS46108.1
    UniProtKB/TrEMBL
    A0A158VUY4
    Related
    ENSP00000351627.4, ENST00000358777.10
    Conserved Domains (2) summary
    cd00096
    Location:42 → 44
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:36 → 140
    Ig; Immunoglobulin domain

  2. NM_001389722.1 → NP_001376651.1  carcinoembryonic antigen-related cell adhesion molecule 19 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC243964
    Consensus CDS
    CCDS46108.1
    UniProtKB/TrEMBL
    A0A158VUY4
    Conserved Domains (2) summary
    cd00096
    Location:42 → 44
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:36 → 140
    Ig; Immunoglobulin domain

  3. NM_020219.5 → NP_064604.2  carcinoembryonic antigen-related cell adhesion molecule 19 isoform 2 precursor

    See identical proteins and their annotated locations for NP_064604.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is longer and has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC243964
    Consensus CDS
    CCDS12641.1
    UniProtKB/Swiss-Prot
    Q5XJ15, Q7Z692, Q7Z693
    UniProtKB/TrEMBL
    A0A158VVV8
    Related
    ENSP00000384887.3, ENST00000403660.3
    Conserved Domains (1) summary
    cl11960
    Location:36 → 140
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44665860..44684355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    47490642..47509104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z692.2 GenPept UniProtKB/Swiss-Prot:Q7Z692

Gene LinkOut

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