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PSMG2 proteasome assembly chaperone 2 [ Homo sapiens (human) ]

Gene ID: 56984, updated on 17-Jun-2024

Summary

Official Symbol
PSMG2provided by HGNC
Official Full Name
proteasome assembly chaperone 2provided by HGNC
Primary source
HGNC:HGNC:24929
See related
Ensembl:ENSG00000128789 MIM:609702; AllianceGenome:HGNC:24929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAC2; HCCA3; CLAST3; MDS003; PRAAS4; HsT1707; TNFSF5IP1
Summary
Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Located in nucleus. Part of chaperone complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 46.4), bone marrow (RPKM 28.3) and 25 other tissues See more
Orthologs
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Genomic context

See PSMG2 in Genome Data Viewer
Location:
18p11.21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (12658738..12725740)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (12821722..12888739)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12658737..12725739)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr18:12465167-12465325 Neighboring gene high mobility group box 3 pseudogene 28 Neighboring gene spire type actin nucleation factor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:12494438-12494637 Neighboring gene MPRA-validated peak3058 silencer Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9314 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:12647566-12648390 Neighboring gene NANOG hESC enhancer GRCh37_chr18:12651568-12652151 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:12658125-12658293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:12701867-12702764 Neighboring gene centrosomal protein 76 Neighboring gene NANOG hESC enhancer GRCh37_chr18:12722786-12723287 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:12734331-12734497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13105 Neighboring gene long intergenic non-protein coding RNA 1882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:12766527-12767028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:12767029-12767528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13106 Neighboring gene protein tyrosine phosphatase non-receptor type 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13109 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:12843102-12843610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:12860375-12861038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:12873719-12874330 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:12875558-12876170 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:12878042-12878251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9320

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC15092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chaperone-mediated protein complex assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in proteasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein folding chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome assembly chaperone 2
Names
CD40 ligand-activated specific transcript 3
HDCMC29P
HSPC260
PAC-2
hepatocellular carcinoma susceptibility protein
hepatocellular carcinoma-susceptibility protein 3
likely ortholog of mouse CD40 ligand-activated specific transcript 3 (Clast3)
proteasome (prosome, macropain) assembly chaperone 2
proteasome assembling chaperone 2
tumor necrosis factor superfamily member 5-induced protein 1
x 003 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020232.5NP_064617.2  proteasome assembly chaperone 2 isoform 1

    See identical proteins and their annotated locations for NP_064617.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK057005, BC013356, BF668035
    Consensus CDS
    CCDS11862.1
    UniProtKB/Swiss-Prot
    B0YJB3, Q6IAH4, Q969U7, Q9NRV1, V9GYH7
    UniProtKB/TrEMBL
    A0A8V8TNA9
    Related
    ENSP00000325919.6, ENST00000317615.11
    Conserved Domains (1) summary
    pfam09754
    Location:17123
    PAC2; PAC2 family
  2. NM_147163.2NP_671692.1  proteasome assembly chaperone 2 isoform 2

    See identical proteins and their annotated locations for NP_671692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF068295, AK057005, AP005482, BC013356
    Consensus CDS
    CCDS67440.1
    UniProtKB/TrEMBL
    Q9P1R6
    Related
    ENSP00000476763.1, ENST00000585331.6
    Conserved Domains (1) summary
    pfam09754
    Location:295
    PAC2; PAC2 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    12658738..12725740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    12821722..12888739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)