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AKR1B10 aldo-keto reductase family 1 member B10 [ Homo sapiens (human) ]

Gene ID: 57016, updated on 11-Apr-2024

Summary

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Official Symbol
AKR1B10provided by HGNC
Official Full Name
aldo-keto reductase family 1 member B10provided by HGNC
Primary source
HGNC:HGNC:382
See related
Ensembl:ENSG00000198074 MIM:604707; AllianceGenome:HGNC:382
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12
Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 190.1), stomach (RPKM 138.2) and 4 other tissues See more
Orthologs
all
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Genomic context

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Location:
7q33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (134527567..134541412)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (135835650..135849492)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134212319..134226164)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:134132907-134134106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18673 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:134147917-134148417 Neighboring gene endogenous retrovirus group 3 member 1 pseudogene Neighboring gene aldo-keto reductase family 1 member B Neighboring gene Sharpr-MPRA regulatory region 13664 Neighboring gene uncharacterized LOC105375520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26690 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134247191-134248390 Neighboring gene aldo-keto reductase family 1 member B15 Neighboring gene uncharacterized LOC124901750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26691 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26693 Neighboring gene Sharpr-MPRA regulatory region 13526 Neighboring gene bisphosphoglycerate mutase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of AKR1B10 Predicts Poor Prognosis in Gastric Cancer Patients Undergoing Surgical Resection. Liu YY, et al. Curr Oncol, 2022 Dec 21. PMID 36661656, Free PMC Article
  2. AKR1B10 accelerates the production of proinflammatory cytokines via the NF-κB signaling pathway in colon cancer. Liu C, et al. J Mol Histol, 2022 Oct. PMID 35920984
  3. Plasma Aldo-Keto Reductase Family 1 Member B10 as a Biomarker Performs Well in the Diagnosis of Nonalcoholic Steatohepatitis and Fibrosis. Park A, et al. Int J Mol Sci, 2022 May 1. PMID 35563425, Free PMC Article
  4. AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory Syndrome. Chabert C, et al. Int J Mol Sci, 2022 Feb 8. PMID 35163833, Free PMC Article
  5. AKR1B10 inhibits the proliferation and migration of gastric cancer via regulating epithelial-mesenchymal transition. Shao X, et al. Aging (Albany NY), 2021 Sep 22. PMID 34552036, Free PMC Article

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aldo-keto Reductase 1B10 Restrains Cell Migration, Invasion, and Adhesion of Gastric Cancer via Regulating Integrin Subunit Alpha 5.
    Title: Aldo-keto Reductase 1B10 Restrains Cell Migration, Invasion, and Adhesion of Gastric Cancer via Regulating Integrin Subunit Alpha 5.
  2. Serum AKR1B10 as an indicator of unfavorable survival of hepatocellular carcinoma.
    Title: Serum AKR1B10 as an indicator of unfavorable survival of hepatocellular carcinoma.
  3. AKR1B10 regulates M2 macrophage polarization to promote the malignant phenotype of gastric cancer.
    Title: AKR1B10 regulates M2 macrophage polarization to promote the malignant phenotype of gastric cancer.
  4. RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.
    Title: RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.
  5. Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis.
    Title: Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis.
  6. Overexpression of AKR1B10 Predicts Poor Prognosis in Gastric Cancer Patients Undergoing Surgical Resection.
    Title: Overexpression of AKR1B10 Predicts Poor Prognosis in Gastric Cancer Patients Undergoing Surgical Resection.
  7. AKR1B10 accelerates the production of proinflammatory cytokines via the NF-kappaB signaling pathway in colon cancer.
    Title: AKR1B10 accelerates the production of proinflammatory cytokines via the NF-κB signaling pathway in colon cancer.
  8. Plasma Aldo-Keto Reductase Family 1 Member B10 as a Biomarker Performs Well in the Diagnosis of Nonalcoholic Steatohepatitis and Fibrosis.
    Title: Plasma Aldo-Keto Reductase Family 1 Member B10 as a Biomarker Performs Well in the Diagnosis of Nonalcoholic Steatohepatitis and Fibrosis.
  9. E2F1-mediated AUF1 upregulation promotes HCC development and enhances drug resistance via stabilization of AKR1B10.
    Title: E2F1-mediated AUF1 upregulation promotes HCC development and enhances drug resistance via stabilization of AKR1B10.
  10. AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory Syndrome.
    Title: AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory Syndrome.
Submit: New GeneRIF Correction See all GeneRIFs (111)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14103

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alcohol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldo-keto reductase (NADPH) activity TAS
Traceable Author Statement
more info
 PubMed 
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables allyl-alcohol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables geranylgeranyl reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables indanol dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables retinal dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular detoxification of aldehyde IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in daunorubicin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in doxorubicin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in farnesol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinoid metabolic process TAS
Traceable Author Statement
more info
  
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1 member B10
Names
ARP
SI reductase
aldo-keto reductase family 1, member B10 (aldose reductase)
aldo-keto reductase family 1, member B11 (aldose reductase-like)
aldose reductase-like 1
aldose reductase-like peptide
aldose reductase-related protein
hARP
small intestine reductase
NP_064695.3
XP_011514718.1
XP_011514719.1
XP_047276590.1
XP_054214657.1
XP_054214658.1
XP_054214659.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020299.5 → NP_064695.3  aldo-keto reductase family 1 member B10

    See identical proteins and their annotated locations for NP_064695.3

    Status: REVIEWED

    Source sequence(s)
    AC078847, AF052577, AF524864, BC008837, BM975664
    Consensus CDS
    CCDS5832.1
    UniProtKB/Swiss-Prot
    A4D1P1, O60218, O75890, Q6FHF3, Q8IWZ1
    UniProtKB/TrEMBL
    A4D1P0
    Related
    ENSP00000352584.4, ENST00000359579.5
    Conserved Domains (1) summary
    cd19107
    Location:10 → 316
    AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    134527567..134541412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516416.2 → XP_011514718.1  aldo-keto reductase family 1 member B10 isoform X2

    Conserved Domains (2) summary
    COG0656
    Location:1 → 258
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 250
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  2. XM_047420634.1 → XP_047276590.1  aldo-keto reductase family 1 member B10 isoform X1

  3. XM_011516417.3 → XP_011514719.1  aldo-keto reductase family 1 member B10 isoform X3

    Conserved Domains (2) summary
    COG0656
    Location:1 → 120
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 113
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    135835650..135849492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358683.1 → XP_054214658.1  aldo-keto reductase family 1 member B10 isoform X2

  2. XM_054358682.1 → XP_054214657.1  aldo-keto reductase family 1 member B10 isoform X1

  3. XM_054358684.1 → XP_054214659.1  aldo-keto reductase family 1 member B10 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60218.2 GenPept UniProtKB/Swiss-Prot:O60218

Gene LinkOut

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