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CIAPIN1 cytokine induced apoptosis inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 57019, updated on 3-Nov-2024

Summary

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Official Symbol
CIAPIN1provided by HGNC
Official Full Name
cytokine induced apoptosis inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:28050
See related
Ensembl:ENSG00000005194 MIM:608943; AllianceGenome:HGNC:28050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRE2; CIAE2; PRO0915; Anamorsin
Summary
CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 38.4), placenta (RPKM 14.2) and 24 other tissues See more
Orthologs
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Genomic context

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See CIAPIN1 in Genome Data Viewer
Location:
16q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57428187..57447385, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63223362..63242561, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57462099..57481297, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57412503-57413083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10892 Neighboring gene C-X3-C motif chemokine ligand 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57417624-57418314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57418315-57419004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10894 Neighboring gene C-C motif chemokine ligand 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57450029-57450544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57450545-57451060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57451577-57452091 Neighboring gene Sharpr-MPRA regulatory region 5957 Neighboring gene coenzyme Q9 Neighboring gene Sharpr-MPRA regulatory region 83 Neighboring gene RNA polymerase II subunit C Neighboring gene docking protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cytokine-induced apoptosis inhibitor-1 causes dedifferentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways. Yu SM, et al. Int J Biochem Cell Biol, 2016 Nov. PMID 27644154
  2. Crystal structure of the N-terminal methyltransferase-like domain of anamorsin. Song G, et al. Proteins, 2014 Jun. PMID 24123282
  3. Human anamorsin binds [2Fe-2S] clusters with unique electronic properties. Banci L, et al. J Biol Inorg Chem, 2013 Dec. PMID 23989406
  4. CIAPIN1 gene silencing enhances chemosensitivity in a drug-resistant animal model in vivo. Wang XM, et al. Braz J Med Biol Res, 2014 Apr. PMID 24676475, Free PMC Article
  5. CIAPIN1 nuclear accumulation predicts poor clinical outcome in epithelial ovarian cancer. Cai X, et al. World J Surg Oncol, 2012 Jun 19. PMID 22713669, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of CIAPIN1 regulates the proliferation, migration and glycolysis of breast cancer cells via inhibition of STAT3 pathway.
    Title: Downregulation of CIAPIN1 regulates the proliferation, migration and glycolysis of breast cancer cells via inhibition of STAT3 pathway.
  2. High CIAPIN1 expression is correlated with Non-small Cell Lung Cancer.
    Title: MiRNA-195-5p Functions as a Tumor Suppressor and a Predictive of Poor Prognosis in Non-small Cell Lung Cancer by Directly Targeting CIAPIN1.
  3. NHE1 (Na+/H+ exchanger 1) expression and ERK1/2 phosphorylation decreased along with CIAPIN1 upregulation.
    Title: CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells' Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving Pulmonectomy.
  4. The [2Fe-2S] clusters of mitoNEET are reduced via the formation of a transient complex that brings the [2Fe-2S] clusters of mitoNEET close to the redox-active [2Fe-2S] cluster of anamorsin.
    Title: Anamorsin/Ndor1 Complex Reduces [2Fe-2S]-MitoNEET via a Transient Protein-Protein Interaction.
  5. the effects of CIAPIN-1 in chondrocytes, focusing on extracellular signal-regulated kinase (ERK)-1/2 and p38 kinase signaling
    Title: Cytokine-induced apoptosis inhibitor-1 causes dedifferentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways.
  6. results of the present study suggest that downregulation of the CIAPIN1 gene in multiple myeloma cells may be associated with the development of this disease.
    Title: Cytokine-induced apoptosis inhibitor 1 inhibits the growth and proliferation of multiple myeloma.
  7. CIAPIN1 and ABCA13 may be novel markers of poor outcome in pre-chemotherapy serous carcinoma effusions.
    Title: CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma.
  8. CIAPIN1 over-expression decreases NHE1 expression and ERK1/2 phosphorylation.
    Title: CIAPIN1 targets Na⁺/H⁺ exchanger 1 to mediate MDA-MB-231 cells' metastasis through regulation of MMPs via ERK1/2 signaling pathway.
  9. lentivirus-vector-mediated RNAi targeting of CIAPIN1 is a potential approach to reverse MDR of breast cancer and CIAPIN1 may participate in MDR of breast cancer by regulating P-glycoprotein and P53 expression.
    Title: CIAPIN1 gene silencing enhances chemosensitivity in a drug-resistant animal model in vivo.
  10. the 25-kDa cleaved fragment of anamorsin was detected in post-mortem brains of Alzheimer and Parkinson disease patients
    Title: Anamorsin, a novel caspase-3 substrate in neurodegeneration.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
  
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
anamorsin
Names
fe-S cluster assembly protein DRE2 homolog
predicted protein of HQ0915

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308347.2 → NP_001295276.1  anamorsin isoform 2

    See identical proteins and their annotated locations for NP_001295276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 2.
    Source sequence(s)
    AC009052, AL136613
    Consensus CDS
    CCDS76876.1
    UniProtKB/Swiss-Prot
    Q6FI81
    Related
    ENSP00000456114.1, ENST00000567518.5
    Conserved Domains (1) summary
    pfam05093
    Location:227 → 291
    CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

  2. NM_001308358.2 → NP_001295287.1  anamorsin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1. The encoded isoform (3)
    Source sequence(s)
    AF248964, BC067303, BG746807, BJ991015
    Consensus CDS
    CCDS76877.1
    UniProtKB/TrEMBL
    H3BPG7, H3BT65
    Related
    ENSP00000457042.1, ENST00000569370.5
    Conserved Domains (1) summary
    cl17173
    Location:3 → 95
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_020313.4 → NP_064709.2  anamorsin isoform 1

    See identical proteins and their annotated locations for NP_064709.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF248964, BC024196, BC067303
    Consensus CDS
    CCDS10781.2
    UniProtKB/Swiss-Prot
    A8K8B6, O75206, O75207, Q6FI81, Q9H0W1, Q9P1L7
    Related
    ENSP00000377914.4, ENST00000394391.9
    Conserved Domains (2) summary
    pfam05093
    Location:240 → 304
    CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
    cl17173
    Location:3 → 95
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    57428187..57447385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    63223362..63242561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6FI81.2 GenPept UniProtKB/Swiss-Prot:Q6FI81

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