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CORO1B coronin 1B [ Homo sapiens (human) ]

Gene ID: 57175, updated on 5-Mar-2024

Summary

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Official Symbol
CORO1Bprovided by HGNC
Official Full Name
coronin 1Bprovided by HGNC
Primary source
HGNC:HGNC:2253
See related
Ensembl:ENSG00000172725 MIM:609849; AllianceGenome:HGNC:2253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CORONIN-2
Summary
Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in prostate (RPKM 38.7), spleen (RPKM 34.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (67435510..67443809, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (67429626..67437925, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67202981..67211280, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67183887-67184722 Neighboring gene carnosine synthase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67195675-67196442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67196443-67197210 Neighboring gene ribosomal protein S6 kinase B2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67201247-67202008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67203533-67204294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67204572-67205104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67205105-67205637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67205638-67206170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67206171-67206702 Neighboring gene protein tyrosine phosphatase receptor type C associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5099 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67209163-67210002 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67210843-67211682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5101 Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5103 Neighboring gene transmembrane protein 134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67236334-67236958

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Coronin 1B Reorganizes the Architecture of F-Actin Networks for Contractility at Steady-State and Apoptotic Adherens Junctions. Michael M, et al. Dev Cell, 2016 Apr 4. PMID 27046832
  2. Binding of coronin 1B to TβRI negatively regulates the TGFβ1 signaling pathway. Kim GY, et al. Biochem Biophys Res Commun, 2017 Aug 19. PMID 28625921
  3. Coronin 1B serine 2 phosphorylation by p38α is critical for vascular endothelial growth factor-induced migration of human umbilical vein endothelial cells. Kim GY, et al. Cell Signal, 2016 Dec. PMID 27592029
  4. Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. Usatyuk PV, et al. PLoS One, 2013. PMID 23667561, Free PMC Article
  5. Coronin 1B regulates the TNFα-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD. Kim GY, et al. Biochem Biophys Res Commun, 2020 Jun 11. PMID 32303335

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis.
    Title: Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis.
  2. Coronin 1B regulates the TNFalpha-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD.
    Title: Coronin 1B regulates the TNFα-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD.
  3. VEGF-activated p38alpha phosphorylates coronin 1B at Ser2 and activates the Arp2/3 complex by liberating it from coronin 1B.
    Title: Coronin 1B serine 2 phosphorylation by p38α is critical for vascular endothelial growth factor-induced migration of human umbilical vein endothelial cells.
  4. Coronin 1B constitutively binds to TGF beta receptor I in vascular smooth muscle cells.
    Title: Binding of coronin 1B to TβRI negatively regulates the TGFβ1 signaling pathway.
  5. The loss of junctional NMIIA, upon Coronin 1B knockdown, perturbed RhoA signaling.
    Title: Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II.
  6. When cells undergo apoptosis in an epithelial monolayer, coronin 1B is recruited to the junctional cortex at apoptotic/neighbor cell interface in an E-cadherin-dependent fashion to support actin architectural reorganization, contractility, and extrusion.
    Title: Coronin 1B Reorganizes the Architecture of F-Actin Networks for Contractility at Steady-State and Apoptotic Adherens Junctions.
  7. Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis.
    Title: Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction.
  8. analysis of the mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility
    Title: Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility.
  9. Coronin 1B regulates leading edge dynamics and controls cell motility and interactions with the actin-related protein (Arp)2/3 complex
    Title: Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
  10. Study concludes that Coronin 1B's coordination of filament formation by Arp2/3 complex and filament turnover by Cofilin is required for effective lamellipodial protrusion and cell migration.
    Title: Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp762I166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Arp2/3 complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables Arp2/3 complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cadherin binding HDA PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament branching IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to platelet-derived growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of smooth muscle cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lamellipodium morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IC
Inferred by Curator
more info
 PubMed 
involved_in ruffle organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
coronin-1B
Names
coronin, actin binding protein, 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018070.3 → NP_001018080.1  coronin-1B

    See identical proteins and their annotated locations for NP_001018080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003419, BC006449, DA061767
    Consensus CDS
    CCDS8164.1
    UniProtKB/Swiss-Prot
    B2RD45, Q9BR76
    Related
    ENSP00000377471.1, ENST00000393893.5
    Conserved Domains (2) summary
    sd00039
    Location:38 → 80
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:10 → 485
    WD40_4; Type of WD40 repeat

  2. NM_020441.3 → NP_065174.1  coronin-1B

    See identical proteins and their annotated locations for NP_065174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003419, BC006449
    Consensus CDS
    CCDS8164.1
    UniProtKB/Swiss-Prot
    B2RD45, Q9BR76
    Related
    ENSP00000340211.5, ENST00000341356.10
    Conserved Domains (2) summary
    sd00039
    Location:38 → 80
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:10 → 485
    WD40_4; Type of WD40 repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    67435510..67443809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    67429626..67437925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BR76.1 GenPept UniProtKB/Swiss-Prot:Q9BR76

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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