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FAM219B family with sequence similarity 219 member B [ Homo sapiens (human) ]

Gene ID: 57184, updated on 3-Apr-2024

Summary

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Official Symbol
FAM219Bprovided by HGNC
Official Full Name
family with sequence similarity 219 member Bprovided by HGNC
Primary source
HGNC:HGNC:24695
See related
Ensembl:ENSG00000178761 AllianceGenome:HGNC:24695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C15orf17
Expression
Ubiquitous expression in fat (RPKM 16.4), prostate (RPKM 16.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
15q24.1-q24.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (74897963..74906851, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (72767844..72776732, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75192333..75199192, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75134491-75135016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75135085-75135996 Neighboring gene microRNA 6882 Neighboring gene unc-51 like kinase 3 Neighboring gene secretory carrier membrane protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75157901-75158832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75161878-75162388 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75162904-75163889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75182299-75182832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75191053-75191552 Neighboring gene mannose phosphate isomerase Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75197802-75198608 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75198609-75199413 Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75246929-75247862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75247863-75248796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75248797-75249730 Neighboring gene ribonuclease P and MRP subunit p25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of long cDNA clones from human adult spleen. Hattori A, et al. DNA Res, 2000 Dec 31. PMID 11214971
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  3. A proximity-dependent biotinylation map of a human cell. Go CD, et al. Nature, 2021 Jul. PMID 34079125
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00005

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein FAM219B
Names
uncharacterized protein C15orf17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321920.2 → NP_001308849.1  protein FAM219B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), along with variants 1 and 3, encodes isoform a.
    Source sequence(s)
    AC125435, BC064575
    Consensus CDS
    CCDS32295.1
    UniProtKB/Swiss-Prot
    A8K4Q5, B4DK57, Q5XKK7, Q9NXY0
    UniProtKB/TrEMBL
    H3BRU1
    Related
    ENSP00000454719.1, ENST00000563119.5
    Conserved Domains (1) summary
    pfam15260
    Location:72 → 198
    FAM219A; Protein family FAM219A

  2. NM_001321921.2 → NP_001308850.1  protein FAM219B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), along with variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AC125435
    Consensus CDS
    CCDS32295.1
    UniProtKB/Swiss-Prot
    A8K4Q5, B4DK57, Q5XKK7, Q9NXY0
    UniProtKB/TrEMBL
    H3BRU1
    Related
    ENSP00000456404.1, ENST00000563671.5
    Conserved Domains (1) summary
    pfam15260
    Location:72 → 198
    FAM219A; Protein family FAM219A

  3. NM_001321922.2 → NP_001308851.1  protein FAM219B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), along with variant 5, encodes isoform b.
    Source sequence(s)
    AC125435
    UniProtKB/TrEMBL
    H3BRU1
    Related
    ENSP00000454277.1, ENST00000562698.5
    Conserved Domains (1) summary
    pfam15260
    Location:72 → 197
    FAM219A; Protein family FAM219A

  4. NM_001321923.2 → NP_001308852.1  protein FAM219B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), along with variant 4, encodes isoform b.
    Source sequence(s)
    AC125435
    UniProtKB/TrEMBL
    H3BRU1
    Conserved Domains (1) summary
    pfam15260
    Location:72 → 197
    FAM219A; Protein family FAM219A

  5. NM_020447.5 → NP_065180.1  protein FAM219B isoform a

    See identical proteins and their annotated locations for NP_065180.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), along with variants 2 and 3, encodes isoform a.
    Source sequence(s)
    AC125435, DB153105
    Consensus CDS
    CCDS32295.1
    UniProtKB/Swiss-Prot
    A8K4Q5, B4DK57, Q5XKK7, Q9NXY0
    UniProtKB/TrEMBL
    H3BRU1
    Related
    ENSP00000350260.5, ENST00000357635.10
    Conserved Domains (1) summary
    pfam15260
    Location:72 → 198
    FAM219A; Protein family FAM219A

RNA

  1. NR_135841.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  2. NR_135842.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  3. NR_135843.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  4. NR_135844.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  5. NR_135845.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  6. NR_135846.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  7. NR_135847.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  8. NR_135848.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435
    Related
    ENST00000569524.5

  9. NR_135849.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  10. NR_135850.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  11. NR_135851.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  12. NR_135852.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  13. NR_135853.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

  14. NR_135854.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125435

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    74897963..74906851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022433.3 → XP_016877922.1  protein FAM219B isoform X2

    UniProtKB/TrEMBL
    H3BRU1
    Conserved Domains (1) summary
    pfam15260
    Location:72 → 197
    FAM219A; Protein family FAM219A

  2. XM_047432883.1 → XP_047288839.1  protein FAM219B isoform X1

    UniProtKB/Swiss-Prot
    A8K4Q5, B4DK57, Q5XKK7, Q9NXY0

  3. XM_047432884.1 → XP_047288840.1  protein FAM219B isoform X2

RNA

  1. XR_007064481.1 RNA Sequence

  2. XR_243118.5 RNA Sequence

  3. XR_243117.5 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    72767844..72776732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378489.1 → XP_054234464.1  protein FAM219B isoform X2

  2. XM_054378487.1 → XP_054234462.1  protein FAM219B isoform X1

    UniProtKB/Swiss-Prot
    A8K4Q5, B4DK57, Q5XKK7, Q9NXY0

  3. XM_054378488.1 → XP_054234463.1  protein FAM219B isoform X2

RNA

  1. XR_008488998.1 RNA Sequence

  2. XR_008488997.1 RNA Sequence

  3. XR_008488996.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XKK7.1 GenPept UniProtKB/Swiss-Prot:Q5XKK7

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