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LYRM2 LYR motif containing 2 [ Homo sapiens (human) ]

Gene ID: 57226, updated on 5-Mar-2024

Summary

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Official Symbol
LYRM2provided by HGNC
Official Full Name
LYR motif containing 2provided by HGNC
Primary source
HGNC:HGNC:25229
See related
Ensembl:ENSG00000083099 AllianceGenome:HGNC:25229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DJ122O8.2
Expression
Ubiquitous expression in brain (RPKM 12.5), thyroid (RPKM 12.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6q15
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (89632224..89638747, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (90841594..90848122, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90341943..90348466, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 6 Neighboring gene uncharacterized LOC105377889 Neighboring gene OCT4 hESC enhancer GRCh37_chr6:90262750-90263251 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:90265242-90265742 Neighboring gene uncharacterized LOC124901359 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:90319101-90319300 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:90347214-90348413 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:90367565-90368764 Neighboring gene MDN1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 852 Neighboring gene midasin AAA ATPase 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:90399309-90399858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:90405104-90405604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:90405605-90406105 Neighboring gene NANOG hESC enhancer GRCh37_chr6:90430881-90431382 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:90509087-90509820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:90510674-90511174 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:90511175-90511675 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 6 Neighboring gene PIMREG pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation. Huang Q, et al. Cancer Lett, 2019 Jul 28. PMID 31004700
  2. The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly. Dibley MG, et al. Mol Cell Proteomics, 2020 Jan. PMID 31666358, Free PMC Article
  3. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. Robertson NG, et al. Genomics, 1994 Sep 1. PMID 7829101
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Floyd BJ, et al. Mol Cell, 2016 Aug 18. PMID 27499296, Free PMC Article
  5. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. Moutaoufik MT, et al. iScience, 2019 Sep 27. PMID 31536960, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors identified a new Akt-S58phos-LYRM2-Complex I axis, which is responsible for the LYRM2-induced tumor growth and the activation of OXPHOS in colorectal cancer.
    Title: LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ18193, FLJ18317, FLJ21130, MGC104253

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LYR motif-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020466.5 → NP_065199.1  LYR motif-containing protein 2

    See identical proteins and their annotated locations for NP_065199.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AL096678, BC104668, BI492982, BP280644
    Consensus CDS
    CCDS5023.1
    UniProtKB/Swiss-Prot
    B2R4U2, E1P517, Q9NU23
    Related
    ENSP00000430025.1, ENST00000523377.2
    Conserved Domains (1) summary
    pfam05347
    Location:20 → 78
    Complex1_LYR; Complex 1 protein (LYR family)

RNA

  1. NR_028493.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant lacks the translational start codon, as found in variant 1, and it does not appear to be protein-coding.
    Source sequence(s)
    AK094994, AL096678, BI492982, DA160441

  2. NR_028494.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon, compared to variant 1. This variant lacks the translational start codon, as found in variant 1, and it does not appear to be protein-coding.
    Source sequence(s)
    AK311180, AL096678, BI492982, DA160441

  3. NR_028495.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 1. This variant lacks the translational start codon, as found in variant 1, and it does not appear to be protein-coding.
    Source sequence(s)
    AL096678, AV710669, BI492982

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    89632224..89638747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    90841594..90848122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NU23.1 GenPept UniProtKB/Swiss-Prot:Q9NU23

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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