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Ly6i lymphocyte antigen 6 family member I [ Mus musculus (house mouse) ]

Gene ID: 57248, updated on 2-Nov-2024

Summary

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Official Symbol
Ly6iprovided by MGI
Official Full Name
lymphocyte antigen 6 family member Iprovided by MGI
Primary source
MGI:MGI:1888480
See related
Ensembl:ENSMUSG00000022586 AllianceGenome:MGI:1888480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly-6I; Ly-6M
Summary
Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to be located in side of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in mammary gland adult (RPKM 1.7), thymus adult (RPKM 1.2) and 14 other tissues See more
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Genomic context

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See Ly6i in Genome Data Viewer
Location:
15; 15 D3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74851383..74855279, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (74979534..74983434, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1173 Neighboring gene predicted gene, 39556 Neighboring gene STARR-seq mESC enhancer starr_39002 Neighboring gene STARR-positive B cell enhancer ABC_E7383 Neighboring gene lymphocyte antigen 6 family member E Neighboring gene predicted gene 28068 Neighboring gene STARR-positive B cell enhancer ABC_E10863 Neighboring gene predicted gene 8000 Neighboring gene predicted gene, 41348

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ly-6I, a new member of the murine Ly-6 superfamily with a distinct pattern of expression. Pflugh DL, et al. J Immunol, 2000 Jul 1. PMID 10861067
  2. Characterization of Ly-6M, a novel member of the Ly-6 family of hematopoietic proteins. Patterson JM, et al. Blood, 2000 May 15. PMID 10807778
  3. Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1. Stier MT, et al. Mamm Genome, 2012 Apr. PMID 22101863, Free PMC Article
  4. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lymphocyte antigen 6I
Names
lymphocyte antigen 6 complex, locus I
lymphocyte antigen 6M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358005.1 → NP_001344934.1  lymphocyte antigen 6I precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124637
    Consensus CDS
    CCDS27539.1
    UniProtKB/Swiss-Prot
    Q05AA4, Q9WU67
    UniProtKB/TrEMBL
    B7ZN85
    Related
    ENSMUSP00000129867.2, ENSMUST00000166694.2
    Conserved Domains (1) summary
    pfam00021
    Location:29 → 105
    UPAR_LY6; u-PAR/Ly-6 domain

  2. NM_020498.3 → NP_065244.2  lymphocyte antigen 6I precursor

    See identical proteins and their annotated locations for NP_065244.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124637
    Consensus CDS
    CCDS27539.1
    UniProtKB/Swiss-Prot
    Q05AA4, Q9WU67
    UniProtKB/TrEMBL
    B7ZN85
    Related
    ENSMUSP00000023250.5, ENSMUST00000023250.11
    Conserved Domains (1) summary
    pfam00021
    Location:29 → 105
    UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    74851383..74855279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WU67.1 GenPept UniProtKB/Swiss-Prot:Q9WU67

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