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Retn resistin [ Mus musculus (house mouse) ]

Gene ID: 57264, updated on 28-Oct-2024

Summary

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Official Symbol
Retnprovided by MGI
Official Full Name
resistinprovided by MGI
Primary source
MGI:MGI:1888506
See related
Ensembl:ENSMUSG00000012705 AllianceGenome:MGI:1888506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADSF; Rstn; Xcp4; Fizz3
Summary
Predicted to enable hormone activity. Predicted to be involved in several processes, including negative regulation of feeding behavior; positive regulation of cell communication; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Is expressed in adipose tissue. Human ortholog(s) of this gene implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Orthologous to human RETN (resistin). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 408.3), mammary gland adult (RPKM 151.5) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Retn in Genome Data Viewer
Location:
8 A1.1; 8 1.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3705770..3709818)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3655770..3659818)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene PET100 homolog Neighboring gene Purkinje cell protein 2 (L7) Neighboring gene syntaxin binding protein 2 Neighboring gene mast cell expressed membrane protein 1 Neighboring gene Foxo1 corepressor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NO-dependent pathways. Robertson SA, et al. Regul Pept, 2009 Jan 8. PMID 18722482
  2. Resistin/ADSF/FIZZ3 in obesity and diabetes. Sul HS. Trends Endocrinol Metab, 2004 Aug. PMID 15358276
  3. Adenovirus-mediated high expression of resistin causes dyslipidemia in mice. Sato N, et al. Endocrinology, 2005 Jan. PMID 15471967
  4. Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid. Haugen F, et al. J Lipid Res, 2005 Jan. PMID 15489540
  5. Impaired glucose tolerance is accompanied by decreased insulin sensitivity in tissues of mice implanted with cells that overexpress resistin. Kitagawa Y, et al. Diabetologia, 2004 Oct. PMID 15502922

See all (133) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases.
    Title: Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases.
  2. Resistin deletion protects against heart failure injury by targeting DNA damage response.
    Title: Resistin deletion protects against heart failure injury by targeting DNA damage response.
  3. Is resistin the master link between inflammation and inflammation-related chronic diseases?
    Title: Is resistin the master link between inflammation and inflammation-related chronic diseases?
  4. Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1alpha Signaling Pathway in Male NAFLD Mice.
    Title: Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice.
  5. Resistin is co-secreted with adiponectin in white mouse adipocytes.
    Title: Resistin is co-secreted with adiponectin in white mouse adipocytes.
  6. Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin.
    Title: Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin.
  7. Lmo4-resistin signaling contributes to adipose tissue-liver crosstalk upon weight cycling.
    Title: Lmo4-resistin signaling contributes to adipose tissue-liver crosstalk upon weight cycling.
  8. These findings parse a role for Ca(2+) in resistin transactivation and provide support that manipulation of Serca2a-NFATc-Resistin axis might.
    Title: A role for calcium in resistin transcriptional activation in diabetic hearts.
  9. DNA methylation of adiponectin and resistin is affected by short chain fatty acids in a high fat diet
    Title: Effects of SCFA on the DNA methylation pattern of adiponectin and resistin in high-fat-diet-induced obese male mice.
  10. Resistin and TLR4 are part of a new regulatory pathway of neuronal autophagy.
    Title: Resistin inhibits neuronal autophagy through Toll-like receptor 4.
Submit: New GeneRIF Correction See all GeneRIFs (91)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of collagen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of progesterone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
resistin
Names
adipose tissue-specific secretory factor
adipose-specific cysteine-rich secreted protein A12-alpha
cysteine-rich secreted protein FIZZ3
dominant inhibitory adipocyte-specific secretory factor
found in inflammatory zone 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204959.1 → NP_001191888.1  resistin precursor

    See identical proteins and their annotated locations for NP_001191888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK131613, BC051196
    Consensus CDS
    CCDS22068.1
    UniProtKB/Swiss-Prot
    Q99P87
    UniProtKB/TrEMBL
    Q3V2F6, Q5BMX4
    Related
    ENSMUSP00000012849.9, ENSMUST00000012849.15
    Conserved Domains (1) summary
    pfam06954
    Location:26 → 110
    Resistin

  2. NM_022984.4 → NP_075360.1  resistin precursor

    See identical proteins and their annotated locations for NP_075360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF510100
    Consensus CDS
    CCDS22068.1
    UniProtKB/Swiss-Prot
    Q99P87
    UniProtKB/TrEMBL
    Q3V2F6, Q5BMX4
    Related
    ENSMUSP00000133024.3, ENSMUST00000169234.3
    Conserved Domains (1) summary
    pfam06954
    Location:26 → 110
    Resistin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    3705770..3709818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99P87.1 GenPept UniProtKB/Swiss-Prot:Q99P87

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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