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KAT14 lysine acetyltransferase 14 [ Homo sapiens (human) ]

Gene ID: 57325, updated on 5-Mar-2024

Summary

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Official Symbol
KAT14provided by HGNC
Official Full Name
lysine acetyltransferase 14provided by HGNC
Primary source
HGNC:HGNC:15904
See related
Ensembl:ENSG00000149474 MIM:617501; AllianceGenome:HGNC:15904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATAC2; CRP2BP; CSRP2BP; PRO1194; dJ717M23.1
Summary
CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in brain (RPKM 8.7), testis (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

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See KAT14 in Genome Data Viewer
Location:
20p11.23
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (18137153..18188372)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (18188023..18239234)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18117797..18169016)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:18071206-18071706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:18073813-18074384 Neighboring gene ribosomal protein L15 pseudogene 1 Neighboring gene RNA, U7 small nuclear 137 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12701 Neighboring gene PET117 cytochrome c oxidase chaperone Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:18183579-18184079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:18195554-18196054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:18196055-18196555 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:18205955-18206454 Neighboring gene GGCT pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:18232893-18234092 Neighboring gene RNA, 7SL, cytoplasmic 14, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP). Weiskirchen R, et al. Biochem Biophys Res Commun, 2000 Aug 11. PMID 10924333
  2. WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2. Gan Q, et al. J Biol Chem, 2011 Jun 17. PMID 21531708, Free PMC Article
  3. SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers. Krebs AR, et al. Mol Cell, 2011 Nov 4. PMID 22055187, Free PMC Article
  4. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. Wang K, et al. Mol Psychiatry, 2011 Sep. PMID 21079607
  5. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Actin binds directly to the hATAC subunit KAT14, and modulates its histone acetyl transferase activity in vitro and in cells.
    Title: Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.
  2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC15388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables LIM domain binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
cysteine-rich protein 2-binding protein
Names
ADA2A-containing complex subunit 2
ATAC component 2 homolog
CRP2 binding partner
CRP2 binding protein
CSRP2-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384192.3 → NP_001371121.2  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. This variant contains a uORF with the complete coding region for the PET117 protein.
    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS13133.1
    UniProtKB/Swiss-Prot
    A2A2I5, Q96GW6, Q96IH3, Q9H8E8, Q9HBF0, Q9UIY5
    UniProtKB/TrEMBL
    A0A7I2V574
    Related
    ENSP00000366909.3, ENST00000377681.8
    Conserved Domains (1) summary
    pfam00583
    Location:672 → 751
    Acetyltransf_1; Acetyltransferase (GNAT) family

  2. NM_001392069.1 → NP_001378998.1  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS13133.1
    UniProtKB/Swiss-Prot
    A2A2I5, Q96GW6, Q96IH3, Q9H8E8, Q9HBF0, Q9UIY5
    UniProtKB/TrEMBL
    A0A7I2V574
    Related
    ENSP00000392318.2, ENST00000435364.8
    Conserved Domains (1) summary
    pfam00583
    Location:672 → 751
    Acetyltransf_1; Acetyltransferase (GNAT) family

  3. NM_001392070.1 → NP_001378999.1  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS13133.1
    UniProtKB/Swiss-Prot
    A2A2I5, Q96GW6, Q96IH3, Q9H8E8, Q9HBF0, Q9UIY5
    UniProtKB/TrEMBL
    A0A7I2V574
    Related
    ENSP00000504050.1, ENST00000677266.1
    Conserved Domains (1) summary
    pfam00583
    Location:672 → 751
    Acetyltransf_1; Acetyltransferase (GNAT) family

  4. NM_001392071.1 → NP_001379000.1  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS13133.1
    UniProtKB/Swiss-Prot
    A2A2I5, Q96GW6, Q96IH3, Q9H8E8, Q9HBF0, Q9UIY5
    UniProtKB/TrEMBL
    A0A7I2V574
    Related
    ENSP00000503109.1, ENST00000677174.1
    Conserved Domains (1) summary
    pfam00583
    Location:672 → 751
    Acetyltransf_1; Acetyltransferase (GNAT) family

  5. NM_001392072.1 → NP_001379001.1  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS13133.1
    UniProtKB/Swiss-Prot
    A2A2I5, Q96GW6, Q96IH3, Q9H8E8, Q9HBF0, Q9UIY5
    UniProtKB/TrEMBL
    A0A7I2V574
    Conserved Domains (1) summary
    pfam00583
    Location:672 → 751
    Acetyltransf_1; Acetyltransferase (GNAT) family

  6. NM_001392073.1 → NP_001379002.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS93011.1
    UniProtKB/TrEMBL
    A0A075B6H4, A0A7I2V574
    Related
    ENSP00000508684.1, ENST00000688188.1
    Conserved Domains (1) summary
    pfam00583
    Location:671 → 750
    Acetyltransf_1; Acetyltransferase (GNAT) family

  7. NM_001392074.1 → NP_001379003.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS93011.1
    UniProtKB/TrEMBL
    A0A075B6H4, A0A7I2V574
    Related
    ENSP00000504748.1, ENST00000677610.1
    Conserved Domains (1) summary
    pfam00583
    Location:671 → 750
    Acetyltransf_1; Acetyltransferase (GNAT) family

  8. NM_001392075.1 → NP_001379004.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS93011.1
    UniProtKB/TrEMBL
    A0A075B6H4, A0A7I2V574
    Conserved Domains (1) summary
    pfam00583
    Location:671 → 750
    Acetyltransf_1; Acetyltransferase (GNAT) family

  9. NM_001392076.1 → NP_001379005.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS93011.1
    UniProtKB/TrEMBL
    A0A075B6H4, A0A7I2V574
    Conserved Domains (1) summary
    pfam00583
    Location:671 → 750
    Acetyltransf_1; Acetyltransferase (GNAT) family

  10. NM_001392077.1 → NP_001379006.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS93011.1
    UniProtKB/TrEMBL
    A0A075B6H4, A0A7I2V574
    Conserved Domains (1) summary
    pfam00583
    Location:671 → 750
    Acetyltransf_1; Acetyltransferase (GNAT) family

  11. NM_001392078.1 → NP_001379007.1  cysteine-rich protein 2-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS93011.1
    UniProtKB/TrEMBL
    A0A075B6H4, A0A7I2V574
    Conserved Domains (1) summary
    pfam00583
    Location:671 → 750
    Acetyltransf_1; Acetyltransferase (GNAT) family

  12. NM_001392079.1 → NP_001379008.1  cysteine-rich protein 2-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    UniProtKB/TrEMBL
    A0A7I2V574
    Conserved Domains (1) summary
    pfam00583
    Location:650 → 729
    Acetyltransf_1; Acetyltransferase (GNAT) family

  13. NM_001392080.1 → NP_001379009.1  cysteine-rich protein 2-binding protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    UniProtKB/TrEMBL
    A0A7I2V574
    Conserved Domains (1) summary
    pfam00583
    Location:649 → 728
    Acetyltransf_1; Acetyltransferase (GNAT) family

  14. NM_001392081.1 → NP_001379010.1  cysteine-rich protein 2-binding protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    UniProtKB/TrEMBL
    A0A7I2V574
    Conserved Domains (1) summary
    pfam00583
    Location:643 → 722
    Acetyltransf_1; Acetyltransferase (GNAT) family

  15. NM_020536.7 → NP_065397.4  cysteine-rich protein 2-binding protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. This variant contains a uORF which represents a portion of the coding region for the PET117 protein.
    Source sequence(s)
    AL050321, KF459584
    Consensus CDS
    CCDS13133.1
    UniProtKB/Swiss-Prot
    A2A2I5, Q96GW6, Q96IH3, Q9H8E8, Q9HBF0, Q9UIY5
    UniProtKB/TrEMBL
    A0A7I2V574
    Related
    ENSP00000503493.1, ENST00000676935.1
    Conserved Domains (1) summary
    pfam00583
    Location:672 → 751
    Acetyltransf_1; Acetyltransferase (GNAT) family

RNA

  1. NR_028402.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL050321, KF459584
    Related
    ENST00000489634.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    18137153..18188372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    18188023..18239234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177926.1: Suppressed sequence

    Description
    NM_177926.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H8E8.3 GenPept UniProtKB/Swiss-Prot:Q9H8E8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous