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PTGFR prostaglandin F receptor [ Homo sapiens (human) ]

Gene ID: 5737, updated on 2-Nov-2024

Summary

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Official Symbol
PTGFRprovided by HGNC
Official Full Name
prostaglandin F receptorprovided by HGNC
Primary source
HGNC:HGNC:9600
See related
Ensembl:ENSG00000122420 MIM:600563; AllianceGenome:HGNC:9600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FP
Summary
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 7.8), urinary bladder (RPKM 5.1) and 16 other tissues See more
Orthologs
mouse all
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Genomic context

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See PTGFR in Genome Data Viewer
Location:
1p31.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (78490974..78540701)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (78329334..78379549)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78956659..79006386)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:78702835-78703748 Neighboring gene uncharacterized MGC27382 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:78805687-78806886 Neighboring gene RNA, 5S ribosomal pseudogene 23 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:78957125-78957657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1237 Neighboring gene interferon induced protein 44 like Neighboring gene interferon induced protein 44

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of the ERC motif in the proximal part of the second intracellular loop and the C-terminal domain of the human prostaglandin F2alpha receptor (hFP-R) in G-protein coupling control. Pathe-Neuschäfer-Rube A, et al. Biochem J, 2005 May 15. PMID 15651980, Free PMC Article
  2. Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. Kunapuli P, et al. J Biol Chem, 1997 Oct 24. PMID 9341156
  3. Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene. Betz R, et al. Biochem Biophys Res Commun, 1999 Jan 19. PMID 9918852
  4. Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Neuschäfer-Rube F, et al. Biochem J, 2003 Apr 15. PMID 12519077, Free PMC Article
  5. Labour is associated with decreased expression of the PGF2alpha receptor (PTGFR) and a novel PTGFR splice variant in human myometrium but not decidua. Hay A, et al. Mol Hum Reprod, 2010 Oct. PMID 20519365

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ligand-induced activation and G protein coupling of prostaglandin F2alpha receptor.
    Title: Ligand-induced activation and G protein coupling of prostaglandin F(2α) receptor.
  2. Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip.
    Title: Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip.
  3. Data, including data from studies using transgenic mice, suggest that signaling via prostaglandin-F2alpha/PTGFR and Camk2g/p38/Foxo1 MAP kinase/calcium pathways are involved in regulation of hepatic gluconeogenesis in both obesity and fasting. (PTGFR = prostaglandin F2alpha receptor; Camk2g = calcium-calmodulin-dependent protein kinase type 2 gamma; p38 = p38 MAP kinase; Foxo1 = forkhead box transcription factor O1)
    Title: Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
  4. Data suggest that allosteric communication between heterodimeric AT1R and PTGFR is mediated through GNAQ and may also involve proximal phospholipase C but not distal protein kinase C signaling partners; PTGFR activation has negligible effects on AT1R-based conformational biosensors. (AT1R = angiotensin II receptor, type 1; PTGFR = prostaglandin F2alpha receptor; GNAQ = GTP-binding protein G[q] subunit alpha)
    Title: Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.
  5. The genotype frequencies of six SNPs in AFAP1, GMDS and PTGFR genes were conformed to Hardy-Weinberg equilibrium (HWE).
    Title: Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with intra-ocular pressure response to latanoprost in patients with primary open-angle glaucoma.
  6. these results indicated that the actions of AKR1C3 can produce FP receptor ligands whose activation results in carcinoma cell survival in breast cancer.
    Title: 11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancer.
  7. The results indicated that the rs12731181 G allele of the Prostaglandin F2alpha Receptor Gene was associated with susceptibility to essential hypertension.
    Title: Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population.
  8. Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients
    Title: Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients.
  9. The SNPs of the PTGFR and MMP-1 genes may determine the latanoprost response in a white European Spanish population.
    Title: Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma.
  10. Angiotensin II type I and prostaglandin F2alpha receptors cooperatively modulate signaling in vascular smooth muscle cells
    Title: Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
EBI GWAS Catalog
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC46203, MGC120498

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables prostaglandin F receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin F receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to prostaglandin D stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in parturition TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
prostaglandin F2-alpha receptor
Names
FP prostanoid receptor
PGF receptor
PGF2 alpha receptor
prostaglandin receptor (2-alpha)
prostanoid FP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052997.1 RefSeqGene

    Range
    5001..54728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000959.4 → NP_000950.1  prostaglandin F2-alpha receptor isoform a precursor

    See identical proteins and their annotated locations for NP_000950.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL136324, BC112965
    Consensus CDS
    CCDS686.1
    UniProtKB/Swiss-Prot
    A8K9Y0, P43088, Q2KHP3, Q6RYQ6, Q9P1X4
    Related
    ENSP00000359793.3, ENST00000370757.8
    Conserved Domains (1) summary
    cd15145
    Location:27 → 316
    7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001039585.2 → NP_001034674.1  prostaglandin F2-alpha receptor isoform b precursor

    See identical proteins and their annotated locations for NP_001034674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL136324, BC112965, CD013876
    Consensus CDS
    CCDS30759.1
    UniProtKB/TrEMBL
    F2Z2Z6
    Related
    ENSP00000359792.3, ENST00000370756.3
    Conserved Domains (1) summary
    pfam00001
    Location:44 → 291
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    78490974..78540701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426085.1 → XP_047282041.1  prostaglandin F2-alpha receptor isoform X1

    UniProtKB/Swiss-Prot
    A8K9Y0, P43088, Q2KHP3, Q6RYQ6, Q9P1X4

  2. XM_017001873.1 → XP_016857362.1  prostaglandin F2-alpha receptor isoform X2

    UniProtKB/TrEMBL
    F2Z2Z6

  3. XM_047426101.1 → XP_047282057.1  prostaglandin F2-alpha receptor isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    78329334..78379549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337809.1 → XP_054193784.1  prostaglandin F2-alpha receptor isoform X1

    UniProtKB/Swiss-Prot
    A8K9Y0, P43088, Q2KHP3, Q6RYQ6, Q9P1X4

  2. XM_054337810.1 → XP_054193785.1  prostaglandin F2-alpha receptor isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43088.1 GenPept UniProtKB/Swiss-Prot:P43088

Gene LinkOut

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