CG41520 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG41520provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0087011
Locus tag: Dmel_CG41520
See related: AllianceGenome:FB:FBgn0087011
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17443; CG40067; CG40109; Dmel\CG41520
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase activator activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in embryonic epipharynx; embryonic hypopharynx; embryonic ventral epidermis; and embryonic/larval posterior spiracle. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; brain ischemia; diabetic retinopathy; hereditary angioedema; and hereditary lymphedema. Orthologous to several human genes including ANGPT1 (angiopoietin 1) and ANGPT2 (angiopoietin 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 41A1-41A1; 2-55 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (1649061..1778937)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NT_033778.4 Chromosome 2R Reference Release 6 plus ISO1 MT Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 1700321-1707315 mobile_element_type = transposon:297{}6495

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables transmembrane receptor protein tyrosine kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG41520-PA; CG41520-PB; CG41520-PC; CG41520-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

1649061..1778937

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001201534.1 → NP_001188463.1 uncharacterized protein Dmel_CG41520, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188463.1

Status: REVIEWED

UniProtKB/TrEMBL

E8Z4Z6

Conserved Domains (1) summary

cd00087
Location:398 → 615

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_001110550.2 → NP_001104020.1 uncharacterized protein Dmel_CG41520, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001104020.1

Status: REVIEWED

UniProtKB/TrEMBL

A8QHX1

Conserved Domains (1) summary

cd00087
Location:516 → 717

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_001110549.2 → NP_001104019.1 uncharacterized protein Dmel_CG41520, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001104019.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BIB8

Conserved Domains (1) summary

cd00087
Location:516 → 733

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_001201533.1 → NP_001188462.1 uncharacterized protein Dmel_CG41520, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188462.1

Status: REVIEWED

UniProtKB/TrEMBL

E8Z4Z5