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Polr2K RNA polymerase II, I and III subunit K [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740790, updated on 2-Nov-2024

Summary

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Official Symbol
Polr2Kprovided by FlyBase
Official Full Name
RNA polymerase II, I and III subunit Kprovided by FlyBase
Primary source
FLYBASE:FBgn0262954
Locus tag
Dmel_CG34186
See related
AllianceGenome:FB:FBgn0262954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG34186; Dmel\CG34186; Rpb12; RPB12; RPC10
Summary
Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human POLR2K (RNA polymerase II, I and III subunit K). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Polr2K in Genome Data Viewer
Location:
51E2-51E2; 2-74 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15144968..15145519, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11032473..11033024, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44457 Neighboring gene charlatan Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assessment of the roles of Spt5-nucleic acid contacts in promoter proximal pausing of RNA polymerase II. Dollinger R, et al. J Biol Chem, 2023 Sep. PMID 37517697, Free PMC Article
  2. Identification of potential pathways and biomarkers linked to progression in ALS. Huber RG, et al. Ann Clin Transl Neurol, 2023 Feb. PMID 36533811, Free PMC Article
  3. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
  4. Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation. Aoyagi N, et al. J Cell Biol, 2000 Jul 24. PMID 10908585, Free PMC Article
  5. An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator pumilio. Lin WH, et al. J Neurogenet, 2018 Mar-Jun. PMID 29718742, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase I activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase III activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA transcription by RNA polymerase III ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription by RNA polymerase I ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RNA polymerase II, I and III subunit K
Names
CG34186-PA
Polr2K-PA
Rpb12
NP_001097319.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15144968..15145519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103849.3 → NP_001097319.1  RNA polymerase II, I and III subunit K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097319.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6IGE3
    Conserved Domains (1) summary
    smart00659
    Location:14 → 57
    RPOLCX; RNA polymerase subunit CX
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IGE3 Q6IGE3

Gene LinkOut

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