Zc3h8 zinc finger CCCH type containing 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zc3h8provided by MGI
Official Full Name: zinc finger CCCH type containing 8provided by MGI
Primary source: MGI:MGI:1930128
See related: Ensembl:ENSMUSG00000027387 AllianceGenome:MGI:1930128
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fliz1; Zc3hdc8; E130108N08Rik
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; liver; and spleen. Orthologous to human ZC3H8 (zinc finger CCCH-type containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 4.3), CNS E18 (RPKM 4.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 62.63 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (128768188..128786018, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (128926268..128944084, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using RNA silencing to decrease expression of ZC3H8 in a mouse tumor cell line in vitro, then studied phenotype and cell behavior of the tumor cell line, and further studied ability of those cells to form tumors in mice in vivo.
Title: Regulation of the oncogenic phenotype by the nuclear body protein ZC3H8.
Fliz1 binds specifically to a negative cis-acting element in the intronic regulatory region of GATA-3 and, when overexpressed, can function as a transcriptional repressor of the GATA-3 promoter in vitro and in vivo.
Title: Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in T cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell differentiation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of thymocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in response to antibiotic	ISS Inferred from Sequence or Structural Similarity more info
involved_in snRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in snRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in snRNA transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in snRNA transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in Cajal body	ISS Inferred from Sequence or Structural Similarity more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in euchromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in histone locus body	ISO Inferred from Sequence Orthology more info
located_in histone locus body	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription elongation factor complex	ISO Inferred from Sequence Orthology more info
part_of transcription elongation factor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger CCCH domain-containing protein 8

Names: fetal liver zinc finger 1; fetal liver zinc finger 1; putative zinc finger protein FLIZ1; fetal liver zinc finger protein 1; zinc finger CCCH type domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020594.2 → NP_065619.2 zinc finger CCCH domain-containing protein 8

See identical proteins and their annotated locations for NP_065619.2

Status: VALIDATED

Source sequence(s)

BC048687, CJ167668

Consensus CDS

CCDS16718.1

UniProtKB/Swiss-Prot

Q80X92, Q9JJ48

UniProtKB/TrEMBL

Q3TPC9

Related

ENSMUSP00000028866.9, ENSMUST00000028866.9

Conserved Domains (1) summary

smart00356
Location:240 → 260

ZnF_C3H1; zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

128768188..128786018 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499947.3 → XP_006500010.1 zinc finger CCCH domain-containing protein 8 isoform X1

UniProtKB/TrEMBL

Q3TPC9

Conserved Domains (1) summary

COG5084
Location:206 → 278

YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]