Zmynd15 zinc finger, MYND-type containing 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zmynd15provided by MGI
Official Full Name: zinc finger, MYND-type containing 15provided by MGI
Primary source: MGI:MGI:3603821
See related: Ensembl:ENSMUSG00000040829 AllianceGenome:MGI:3603821
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables histone deacetylase binding activity. Acts upstream of or within negative regulation of DNA-templated transcription and spermatid development. Located in cytoplasm and male germ cell nucleus. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in spermatogenic failure 14. Orthologous to human ZMYND15 (zinc finger MYND-type containing 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 57.0), thymus adult (RPKM 8.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70350259..70357028)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70459433..70466204)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZMYND15 represents the first transcriptional repressor identified to be essential for sperm production and male fertility.
Title: Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatid development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger MYND domain-containing protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029929.3 → NP_001025100.1 zinc finger MYND domain-containing protein 15 isoform 1

See identical proteins and their annotated locations for NP_001025100.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK029988, AL596096, BY206104

Consensus CDS

CCDS24949.1

UniProtKB/Swiss-Prot

Q3TAD1, Q8C0R7

UniProtKB/TrEMBL

A2A642, A2CFF1

Related

ENSMUSP00000048816.4, ENSMUST00000039093.10

Conserved Domains (1) summary

pfam01753
Location:307 → 353

zf-MYND; MYND finger
NM_001348337.1 → NP_001335266.1 zinc finger MYND domain-containing protein 15 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK029988, AL596096, BY206104

Consensus CDS

CCDS88182.1

UniProtKB/TrEMBL

A2A642

Related

ENSMUSP00000104203.3, ENSMUST00000108563.9

Conserved Domains (1) summary

pfam01753
Location:177 → 223

zf-MYND; MYND finger