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GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 [ Homo sapiens (human) ]

Gene ID: 57452, updated on 5-Mar-2024

Summary

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Official Symbol
GALNT16provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 16provided by HGNC
Primary source
HGNC:HGNC:23233
See related
Ensembl:ENSG00000100626 MIM:615132; AllianceGenome:HGNC:23233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GALNTL1; GALNACT16; GalNAc-T16
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 7.7), heart (RPKM 6.0) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
14q24.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (69259631..69386337)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (63472675..63600865)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (69726875..69823759)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2739 Neighboring gene DDB1 and CUL4 associated factor 5 Neighboring gene DEAD-box helicase 18 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 12367 Neighboring gene Sharpr-MPRA regulatory region 6895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5878 Neighboring gene GALNT16 and EXD2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5879 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:69705439-69706063 Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5880 Neighboring gene uncharacterized LOC105370549 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69800956-69801456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69801457-69801957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69815418-69815918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8636 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69864016-69864524 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69864525-69865032 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:69865025-69865265 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:69865234-69866433 Neighboring gene solute carrier family 39 member 9 Neighboring gene ERH mRNA splicing and mitosis factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5881 Neighboring gene pleckstrin homology and coiled-coil domain containing D1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36437

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evaluation of GALNT16 polymorphisms to breast cancer risk in Chinese population. Wu H, et al. Mol Genet Genomic Med, 2019 Aug. PMID 31286696, Free PMC Article
  2. Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK. Peng C, et al. J Exp Clin Cancer Res, 2021 Aug 27. PMID 34452628, Free PMC Article
  3. UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Raman J, et al. Glycobiology, 2012 Jun. PMID 22186971, Free PMC Article
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. Hirosawa M, et al. DNA Res, 1999 Oct 29. PMID 10574461
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK.
    Title: Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK.
  2. rs2105269 and rs72625676 were associated with higher breast cancer (BC) risk in younger patients with age </=51. For rs1275678 polymorphism, there was a significantly decreased risk of BC among older patients. rs2105269 was associated with tumor size and lymph node metastasis. Study suggests that GALNT16 polymorphisms are associated with BC susceptibility in Chinese population.
    Title: Evaluation of GALNT16 polymorphisms to breast cancer risk in Chinese population.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1130, MGC141855

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation via serine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation via threonine IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 16
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
galNAc-T-like protein 1
polypeptide GalNAc transferase 16
polypeptide GalNAc transferase-like protein 1
polypeptide N-acetylgalactosaminyltransferase-like protein 1
pp-GaNTase-like protein 1
protein-UDP acetylgalactosaminyltransferase-like protein 1
putative polypeptide N-acetylgalactosaminyltransferase-like protein 1
NP_001161840.1
NP_065743.2
XP_011535308.1
XP_011535309.1
XP_016876987.1
XP_047287574.1
XP_054232422.1
XP_054232423.1
XP_054232424.1
XP_054232425.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168368.2 → NP_001161840.1  polypeptide N-acetylgalactosaminyltransferase 16

    See identical proteins and their annotated locations for NP_001161840.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK091426, AK289745, AL157996, AL359317, DA493083
    Consensus CDS
    CCDS32107.1
    UniProtKB/Swiss-Prot
    Q4KMG3, Q58A55, Q8N428, Q9ULT9
    UniProtKB/TrEMBL
    Q68VJ8
    Related
    ENSP00000402970.3, ENST00000448469.8
    Conserved Domains (2) summary
    cd02510
    Location:126 → 420
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:441 → 543
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_020692.3 → NP_065743.2  polypeptide N-acetylgalactosaminyltransferase 16

    See identical proteins and their annotated locations for NP_065743.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL157996, AL359317, BC098578, BG059801, DA493083
    Consensus CDS
    CCDS32107.1
    UniProtKB/Swiss-Prot
    Q4KMG3, Q58A55, Q8N428, Q9ULT9
    UniProtKB/TrEMBL
    Q68VJ8
    Related
    ENSP00000336729.4, ENST00000337827.8
    Conserved Domains (2) summary
    cd02510
    Location:126 → 420
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:441 → 543
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    69259631..69386337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021498.2 → XP_016876987.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

    UniProtKB/Swiss-Prot
    Q4KMG3, Q58A55, Q8N428, Q9ULT9
    UniProtKB/TrEMBL
    Q68VJ8
    Conserved Domains (2) summary
    cd02510
    Location:126 → 420
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:441 → 543
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. XM_047431618.1 → XP_047287574.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

    UniProtKB/Swiss-Prot
    Q4KMG3, Q58A55, Q8N428, Q9ULT9
    UniProtKB/TrEMBL
    Q68VJ8
    Related
    ENSP00000451200.1, ENST00000553669.1

  3. XM_011537006.4 → XP_011535308.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

    See identical proteins and their annotated locations for XP_011535308.1

    UniProtKB/Swiss-Prot
    Q4KMG3, Q58A55, Q8N428, Q9ULT9
    UniProtKB/TrEMBL
    Q68VJ8
    Conserved Domains (2) summary
    cd02510
    Location:126 → 420
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:441 → 543
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  4. XM_011537007.4 → XP_011535309.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X2

    Related
    ENSP00000451420.1, ENST00000553471.6
    Conserved Domains (3) summary
    cd02510
    Location:126 → 420
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:126 → 222
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:441 → 514
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RNA

  1. XR_007064036.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    63472675..63600865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376447.1 → XP_054232422.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

    UniProtKB/Swiss-Prot
    Q4KMG3, Q58A55, Q8N428, Q9ULT9
    UniProtKB/TrEMBL
    Q68VJ8

  2. XM_054376449.1 → XP_054232424.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

    UniProtKB/Swiss-Prot
    Q4KMG3, Q58A55, Q8N428, Q9ULT9
    UniProtKB/TrEMBL
    Q68VJ8

  3. XM_054376448.1 → XP_054232423.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

    UniProtKB/Swiss-Prot
    Q4KMG3, Q58A55, Q8N428, Q9ULT9
    UniProtKB/TrEMBL
    Q68VJ8

  4. XM_054376450.1 → XP_054232425.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X2

RNA

  1. XR_008488885.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N428.2 GenPept UniProtKB/Swiss-Prot:Q8N428

Gene LinkOut

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