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STAMBPL1 STAM binding protein like 1 [ Homo sapiens (human) ]

Gene ID: 57559, updated on 11-Apr-2024

Summary

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Official Symbol
STAMBPL1provided by HGNC
Official Full Name
STAM binding protein like 1provided by HGNC
Primary source
HGNC:HGNC:24105
See related
Ensembl:ENSG00000138134 MIM:612352; AllianceGenome:HGNC:24105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMSH-FP; AMSH-LP; ALMalpha; bA399O19.2
Summary
Predicted to enable Lys63-specific deubiquitinase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein K63-linked deubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal (RPKM 7.5), testis (RPKM 6.2) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See STAMBPL1 in Genome Data Viewer
Location:
10q23.31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88880245..88923487)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89763682..89807429)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90640002..90683244)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3725 Neighboring gene lipase family member M Neighboring gene ankyrin repeat domain 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3726 Neighboring gene uncharacterized LOC124902551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3727 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:90641731-90642930 Neighboring gene pentatricopeptide repeat domain 2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3731 Neighboring gene ACTA2 antisense RNA 1 Neighboring gene actin alpha 2, smooth muscle Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:90749708-90750219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:90750220-90750730 Neighboring gene Fas cell surface death receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3733 Neighboring gene FAS antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Quantum Mechanics and Molecular Mechanics Study of the Catalytic Mechanism of Human AMSH-LP Domain Deubiquitinating Enzymes. Zhu W, et al. Biochemistry, 2015 Aug 25. PMID 26256234
  2. STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression. Liu R, et al. Oncogene, 2022 Apr. PMID 35236965
  3. Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1. Guo Y, et al. J Biol Chem, 2021 Oct. PMID 34425109, Free PMC Article
  4. Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas. Ambroise G, et al. Br J Cancer, 2020 Sep. PMID 32636467, Free PMC Article
  5. Targeting the deubiquitinase STAMBPL1 triggers apoptosis in prostate cancer cells by promoting XIAP degradation. Chen X, et al. Cancer Lett, 2019 Aug 1. PMID 31004702

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway.
    Title: Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway.
  2. STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression.
    Title: STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression.
  3. E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
    Title: E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
  4. Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death.
    Title: Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death.
  5. Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1.
    Title: Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1.
  6. The Long Non-Coding RNA NEAT1 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating miR-103a/ STAMBPL1 Axis.
    Title: The Long Non-Coding RNA NEAT1 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating miR-103a/ STAMBPL1 Axis.
  7. Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas.
    Title: Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas.
  8. Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation.
    Title: Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation.
  9. STAMBPL1 depletion induces prostate cancer cell apoptosis by promoting XIAP lysosomal degradation.
    Title: Targeting the deubiquitinase STAMBPL1 triggers apoptosis in prostate cancer cells by promoting XIAP degradation.
  10. Catalytic Mechanism of Human AMSH-LP Domain Deubiquitinating Enzymes
    Title: Quantum Mechanics and Molecular Mechanics Study of the Catalytic Mechanism of Human AMSH-LP Domain Deubiquitinating Enzymes.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31524, KIAA1373

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables K63-linked deubiquitinase activity TAS
Traceable Author Statement
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal-dependent deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to L-leucine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AMSH-like protease
Names
associated molecule with the SH3 domain of STAM (AMSH) - Family Protein
associated molecule with the SH3 domain of STAM (AMSH) like protein
NP_065850.1
XP_006717993.1
XP_011538285.1
XP_011538287.1
XP_016871945.1
XP_016871946.1
XP_016871947.1
XP_047281507.1
XP_047281508.1
XP_047281509.1
XP_047281510.1
XP_047281511.1
XP_054222371.1
XP_054222372.1
XP_054222373.1
XP_054222374.1
XP_054222375.1
XP_054222376.1
XP_054222377.1
XP_054222378.1
XP_054222379.1
XP_054222380.1
XP_054222381.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020799.4 → NP_065850.1  AMSH-like protease

    See identical proteins and their annotated locations for NP_065850.1

    Status: VALIDATED

    Source sequence(s)
    AK056086, AW006657, CD244526
    Consensus CDS
    CCDS7391.1
    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    UniProtKB/TrEMBL
    B3KS69
    Related
    ENSP00000360994.3, ENST00000371926.8
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain
    cl20817
    Location:120 → 198
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    88880245..88923487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425551.1 → XP_047281507.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  2. XM_011539985.3 → XP_011538287.1  AMSH-like protease isoform X1

    See identical proteins and their annotated locations for XP_011538287.1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    UniProtKB/TrEMBL
    B3KS69
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain
    cl20817
    Location:120 → 198
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. XM_006717930.4 → XP_006717993.1  AMSH-like protease isoform X1

    See identical proteins and their annotated locations for XP_006717993.1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    UniProtKB/TrEMBL
    B3KS69
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain
    cl20817
    Location:120 → 198
    GBP_C; Guanylate-binding protein, C-terminal domain

  4. XM_047425553.1 → XP_047281509.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  5. XM_011539983.2 → XP_011538285.1  AMSH-like protease isoform X1

    See identical proteins and their annotated locations for XP_011538285.1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    UniProtKB/TrEMBL
    B3KS69
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain
    cl20817
    Location:120 → 198
    GBP_C; Guanylate-binding protein, C-terminal domain

  6. XM_047425555.1 → XP_047281511.1  AMSH-like protease isoform X2

  7. XM_047425552.1 → XP_047281508.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  8. XM_017016456.2 → XP_016871945.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    UniProtKB/TrEMBL
    B3KS69
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain
    cl20817
    Location:120 → 198
    GBP_C; Guanylate-binding protein, C-terminal domain

  9. XM_017016457.3 → XP_016871946.1  AMSH-like protease isoform X2

    UniProtKB/TrEMBL
    B3KS69

  10. XM_047425554.1 → XP_047281510.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  11. XM_017016458.2 → XP_016871947.1  AMSH-like protease isoform X3

    UniProtKB/TrEMBL
    B3KR00
    Conserved Domains (2) summary
    cd08066
    Location:160 → 330
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    COG0544
    Location:13 → 91
    Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    89763682..89807429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366396.1 → XP_054222371.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  2. XM_054366400.1 → XP_054222375.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  3. XM_054366401.1 → XP_054222376.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  4. XM_054366402.1 → XP_054222377.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  5. XM_054366398.1 → XP_054222373.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  6. XM_054366405.1 → XP_054222380.1  AMSH-like protease isoform X2

  7. XM_054366399.1 → XP_054222374.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  8. XM_054366397.1 → XP_054222372.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  9. XM_054366404.1 → XP_054222379.1  AMSH-like protease isoform X2

  10. XM_054366403.1 → XP_054222378.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4

  11. XM_054366406.1 → XP_054222381.1  AMSH-like protease isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96FJ0.2 GenPept UniProtKB/Swiss-Prot:Q96FJ0

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