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USP36 ubiquitin specific peptidase 36 [ Homo sapiens (human) ]

Gene ID: 57602, updated on 16-Apr-2024

Summary

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Official Symbol
USP36provided by HGNC
Official Full Name
ubiquitin specific peptidase 36provided by HGNC
Primary source
HGNC:HGNC:20062
See related
Ensembl:ENSG00000055483 MIM:612543; AllianceGenome:HGNC:20062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUB1
Summary
This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 11.2), adrenal (RPKM 8.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17q25.3
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78787381..78841439, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79682181..79736241, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76783463..76837521, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904066 Neighboring gene MPRA-validated peak3019 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76662364-76662975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76662976-76663586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76663587-76664197 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:76664198-76664807 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76671141-76672019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76672283-76672784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76672785-76673284 Neighboring gene cytohesin 1 Neighboring gene RNA, U6 small nuclear 638, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76719667-76720172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12905 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12909 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76770651-76771152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9073 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5512 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76834350-76834864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76834865-76835379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12913 Neighboring gene uncharacterized LOC124904067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9075 Neighboring gene MPRA-validated peak3020 silencer Neighboring gene uncharacterized LOC124904068 Neighboring gene Sharpr-MPRA regulatory region 3779 Neighboring gene MPRA-validated peak3021 silencer Neighboring gene ribosomal protein L9 pseudogene 29 Neighboring gene TIMP metallopeptidase inhibitor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gene Signature and Prognostic Value of Ubiquitin-Specific Proteases Members in Hepatocellular Carcinoma and Explored the Immunological Role of USP36. Sun W, et al. Front Biosci (Landmark Ed), 2022 Jun 15. PMID 35748266
  2. Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancer. Li J, et al. Int J Med Sci, 2008 Jun 6. PMID 18566677, Free PMC Article
  3. Deubiquitinating enzyme USP36 contains the PEST motif and is polyubiquitinated. Kim MS, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809067
  4. A novel cysteine protease HeLa DUB-1 responsible for cleaving the ubiquitin in human ovarian cancer cells. Kim MS, et al. Int J Oncol, 2004 Aug. PMID 15254734
  5. The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing. Chen Y, et al. Nucleic Acids Res, 2023 May 8. PMID 36912080, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
    Title: Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
  2. USP36 plays an oncogenic role in colorectal cancer cells.
    Title: USP36 plays an oncogenic role in colorectal cancer cells.
  3. The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.
    Title: The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.
  4. The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.
    Title: The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.
  5. USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP.
    Title: USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP.
  6. CircRNA circUSP36 impairs the stability of NEDD4L mRNA through recruiting PTBP1 to enhance ULK1-mediated autophagic granulosa cell death.
    Title: CircRNA circUSP36 impairs the stability of NEDD4L mRNA through recruiting PTBP1 to enhance ULK1-mediated autophagic granulosa cell death.
  7. DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer.
    Title: DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer.
  8. Gene Signature and Prognostic Value of Ubiquitin-Specific Proteases Members in Hepatocellular Carcinoma and Explored the Immunological Role of USP36.
    Title: Gene Signature and Prognostic Value of Ubiquitin-Specific Proteases Members in Hepatocellular Carcinoma and Explored the Immunological Role of USP36.
  9. USP36 promotes tumor growth of non-small cell lung cancer via increasing KHK-A expression by regulating c-MYC-hnRNPH1/H2 axis.
    Title: USP36 promotes tumor growth of non-small cell lung cancer via increasing KHK-A expression by regulating c-MYC-hnRNPH1/H2 axis.
  10. Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36.
    Title: Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H2B deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleolus organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitophagy HMP PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of rRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 36
Names
deubiquitinating enzyme 36
ubiquitin specific protease 36
ubiquitin thioesterase 36
ubiquitin-specific-processing protease 36
NP_001308220.1
NP_001372098.1
NP_001372099.1
NP_001372100.1
NP_001372101.1
NP_001372102.1
NP_001372103.1
NP_001372104.1
NP_001372105.1
NP_001372106.1
NP_001372107.1
NP_001372108.1
NP_001372109.1
XP_011523367.1
XP_011523368.1
XP_011523370.1
XP_011523371.1
XP_011523373.1
XP_016880390.1
XP_024306613.1
XP_024306614.1
XP_047292424.1
XP_047292425.1
XP_047292426.1
XP_047292427.1
XP_047292428.1
XP_047292429.1
XP_047292430.1
XP_047292431.1
XP_047292432.1
XP_054172735.1
XP_054172736.1
XP_054172737.1
XP_054172738.1
XP_054172739.1
XP_054172740.1
XP_054172741.1
XP_054172742.1
XP_054172743.1
XP_054172744.1
XP_054172745.1
XP_054172746.1
XP_054172747.1
XP_054172748.1
XP_054172749.1
XP_054172750.1
XP_054172751.1
XP_054172752.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321291.2 → NP_001308220.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 3-9, encodes isoform 2.
    Source sequence(s)
    AC022966
    Consensus CDS
    CCDS32755.1
    UniProtKB/Swiss-Prot
    Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
    Related
    ENSP00000441214.1, ENST00000542802.7
    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  2. NM_001385169.1 → NP_001372098.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC022966
    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  3. NM_001385170.1 → NP_001372099.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 4-9, encodes isoform 2.
    Source sequence(s)
    AC022966
    Consensus CDS
    CCDS32755.1
    UniProtKB/Swiss-Prot
    Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  4. NM_001385171.1 → NP_001372100.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 2, 3, and 5-9, encodes isoform 2.
    Source sequence(s)
    AC022966
    Consensus CDS
    CCDS32755.1
    UniProtKB/Swiss-Prot
    Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  5. NM_001385172.1 → NP_001372101.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 2-4 and 6-9, encodes isoform 2.
    Source sequence(s)
    AC022966
    Consensus CDS
    CCDS32755.1
    UniProtKB/Swiss-Prot
    Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  6. NM_001385173.1 → NP_001372102.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 2-5 and 7-9, encodes isoform 2.
    Source sequence(s)
    AC022966
    Consensus CDS
    CCDS32755.1
    UniProtKB/Swiss-Prot
    Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  7. NM_001385174.1 → NP_001372103.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 2-6, 8, and 9, encodes isoform 2.
    Source sequence(s)
    AC022966
    Consensus CDS
    CCDS32755.1
    UniProtKB/Swiss-Prot
    Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
    Related
    ENSP00000401119.4, ENST00000449938.7
    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  8. NM_001385175.1 → NP_001372104.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 2-7 and 9, encodes isoform 2.
    Source sequence(s)
    AC022966
    Consensus CDS
    CCDS32755.1
    UniProtKB/Swiss-Prot
    Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
    Related
    ENSP00000465698.2, ENST00000592231.6
    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  9. NM_001385176.1 → NP_001372105.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 2-8, encodes isoform 2.
    Source sequence(s)
    AC022966
    Consensus CDS
    CCDS32755.1
    UniProtKB/Swiss-Prot
    Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  10. NM_001385177.1 → NP_001372106.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 3.
    Source sequence(s)
    AC022966
    Conserved Domains (2) summary
    PHA03247
    Location:341 → 675
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:1 → 256
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  11. NM_001385178.1 → NP_001372107.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 3.
    Source sequence(s)
    AC022966
    Conserved Domains (2) summary
    PHA03247
    Location:341 → 675
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:1 → 256
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  12. NM_001385179.1 → NP_001372108.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022966
    Conserved Domains (2) summary
    PHA03247
    Location:296 → 630
    PHA03247; large tegument protein UL36; Provisional
    cl02553
    Location:21 → 211
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  13. NM_001385180.1 → NP_001372109.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022966
    UniProtKB/TrEMBL
    B3KMW2
    Conserved Domains (2) summary
    PHA03247
    Location:287 → 621
    PHA03247; large tegument protein UL36; Provisional
    cl02553
    Location:1 → 202
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RNA

  1. NR_169581.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022966

  2. NR_169582.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022966

  3. NR_169583.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022966

  4. NR_169584.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022966

  5. NR_169585.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022966
    Related
    ENST00000693020.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    78787381..78841439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525071.4 → XP_011523373.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X10

    Conserved Domains (2) summary
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:122 → 420
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. XM_011525069.4 → XP_011523371.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X7

    Conserved Domains (2) summary
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:122 → 420
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. XM_011525066.4 → XP_011523368.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    See identical proteins and their annotated locations for XP_011523368.1

    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  4. XM_011525065.3 → XP_011523367.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    See identical proteins and their annotated locations for XP_011523367.1

    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  5. XM_047436472.1 → XP_047292428.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X5

  6. XM_047436470.1 → XP_047292426.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    UniProtKB/Swiss-Prot
    Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275

  7. XM_047436469.1 → XP_047292425.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    UniProtKB/Swiss-Prot
    Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275

  8. XM_024450845.2 → XP_024306613.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  9. XM_024450846.2 → XP_024306614.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:506 → 840
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  10. XM_047436468.1 → XP_047292424.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

  11. XM_011525068.2 → XP_011523370.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

    Conserved Domains (2) summary
    cd02661
    Location:1 → 256
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1 → 255
    UCH; Ubiquitin carboxyl-terminal hydrolase

  12. XM_017024901.2 → XP_016880390.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X4

  13. XM_047436473.1 → XP_047292429.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

  14. XM_047436474.1 → XP_047292430.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X8

  15. XM_047436475.1 → XP_047292431.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X9

  16. XM_047436471.1 → XP_047292427.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X3

  17. XM_047436476.1 → XP_047292432.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X11

    UniProtKB/TrEMBL
    A0A075B784
    Related
    ENSP00000468549.3, ENST00000588086.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    79682181..79736241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316776.1 → XP_054172751.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X10

  2. XM_054316773.1 → XP_054172748.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X7

  3. XM_054316766.1 → XP_054172741.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

  4. XM_054316761.1 → XP_054172736.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

  5. XM_054316760.1 → XP_054172735.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

  6. XM_054316770.1 → XP_054172745.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X5

  7. XM_054316762.1 → XP_054172737.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

  8. XM_054316767.1 → XP_054172742.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

  9. XM_054316765.1 → XP_054172740.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

  10. XM_054316763.1 → XP_054172738.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

  11. XM_054316764.1 → XP_054172739.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

  12. XM_054316772.1 → XP_054172747.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

  13. XM_054316769.1 → XP_054172744.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X4

  14. XM_054316771.1 → XP_054172746.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

  15. XM_054316774.1 → XP_054172749.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X8

  16. XM_054316775.1 → XP_054172750.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X9

  17. XM_054316768.1 → XP_054172743.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X3

  18. XM_054316777.1 → XP_054172752.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X11

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025090.3: Suppressed sequence

    Description
    NM_025090.3: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P275.4 GenPept UniProtKB/Swiss-Prot:Q9P275

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