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USP29 ubiquitin specific peptidase 29 [ Homo sapiens (human) ]

Gene ID: 57663, updated on 3-Nov-2024

Summary

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Official Symbol
USP29provided by HGNC
Official Full Name
ubiquitin specific peptidase 29provided by HGNC
Primary source
HGNC:HGNC:18563
See related
Ensembl:ENSG00000131864 MIM:609546; AllianceGenome:HGNC:18563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOM-TES-84/86
Summary
Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of type I interferon-mediated signaling pathway; and protein K48-linked deubiquitination. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 2.8) See more
Orthologs
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Genomic context

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See USP29 in Genome Data Viewer
Location:
19q13.43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57119087..57131926)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60215749..60228591)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57630455..57643294)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372475 Neighboring gene Sharpr-MPRA regulatory region 3098 Neighboring gene zinc finger protein 300 pseudogene Neighboring gene small nucleolar RNA U3 Neighboring gene zinc finger imprinted 3 Neighboring gene DPPA3 pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination. Chen Z, et al. Front Immunol, 2023. PMID 37304282, Free PMC Article
  2. The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b. Gao W, et al. mBio, 2022 Jun 28. PMID 35638730, Free PMC Article
  3. USP29 activation mediated by FUBP1 promotes AURKB stability and oncogenic functions in gastric cancer. Tu R, et al. Cancer Cell Int, 2024 Jan 17. PMID 38233848, Free PMC Article
  4. Promotive role of USP29-mediated deubiquitination in malignant proliferation of colorectal cancer cells via the KIAA1429/SOX8 axis. Li J, et al. Biomol Biomed, 2023 May 1. PMID 36373629, Free PMC Article
  5. USP29 Deubiquitinates SETD8 and Regulates DNA Damage-Induced H4K20 Monomethylation and 53BP1 Focus Formation. Hernández-Reyes Y, et al. Cells, 2022 Aug 11. PMID 36010569, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.
    Title: Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.
  2. The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b.
    Title: The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b.
  3. USP29 coordinates MYC and HIF1alpha stabilization to promote tumor metabolism and progression.
    Title: USP29 coordinates MYC and HIF1α stabilization to promote tumor metabolism and progression.
  4. USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
    Title: USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
  5. Self-stabilizing regulation of deubiquitinating enzymes in an enzymatic activity-dependent manner.
    Title: Self-stabilizing regulation of deubiquitinating enzymes in an enzymatic activity-dependent manner.
  6. Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
    Title: Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
  7. Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein.
    Title: Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein.
  8. USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro.
    Title: USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC163266, MGC163270

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of type I interferon-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 29
Names
deubiquitinating enzyme 29
ubiquitin thioesterase 29
ubiquitin thiolesterase 29
ubiquitin-specific processing protease
ubiquitin-specific-processing protease 29
NP_001376572.1
NP_001413334.1
NP_001413335.1
NP_065954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389643.1 → NP_001376572.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC025588
    Consensus CDS
    CCDS33124.1
    UniProtKB/Swiss-Prot
    Q9HBJ7
    Related
    ENSP00000470747.1, ENST00000598197.1
    Conserved Domains (3) summary
    cd02257
    Location:823 → 883
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cd13312
    Location:4 → 106
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:286 → 552
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. NM_001426405.1 → NP_001413334.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CP068259
    UniProtKB/TrEMBL
    A1L447

  3. NM_001426406.1 → NP_001413335.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CP068259
    UniProtKB/TrEMBL
    A1L447

  4. NM_020903.3 → NP_065954.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 1

    See identical proteins and their annotated locations for NP_065954.1

    Status: VALIDATED

    Source sequence(s)
    AC025588
    Consensus CDS
    CCDS33124.1
    UniProtKB/Swiss-Prot
    Q9HBJ7
    Related
    ENSP00000254181.3, ENST00000254181.9
    Conserved Domains (3) summary
    cd02257
    Location:823 → 883
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cd13312
    Location:4 → 106
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:286 → 552
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57119087..57131926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60215749..60228591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBJ7.1 GenPept UniProtKB/Swiss-Prot:Q9HBJ7

Gene LinkOut

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