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ZNF529 zinc finger protein 529 [ Homo sapiens (human) ]

Gene ID: 57711, updated on 28-Oct-2024

Summary

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Official Symbol
ZNF529provided by HGNC
Official Full Name
zinc finger protein 529provided by HGNC
Primary source
HGNC:HGNC:29328
See related
Ensembl:ENSG00000186020 AllianceGenome:HGNC:29328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis (RPKM 2.5), endometrium (RPKM 2.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF529 in Genome Data Viewer
Location:
19q13.12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36543613..36605543, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39218884..39280696, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37034515..37096159, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CTBP2 pseudogene 7 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:37018470-37019180 and GRCh37_chr19:37019181-37019889 Neighboring gene zinc finger protein 260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14527 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14529 Neighboring gene zinc finger protein 382 Neighboring gene zinc finger protein 461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14530 Neighboring gene zinc finger protein 567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14531 Neighboring gene ZNF567 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Aug 31. PMID 10997877
  2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  3. Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets. Mihalič F, et al. Nat Commun, 2023 Sep 13. PMID 37704626, Free PMC Article
  4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article
  5. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167880

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 529

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145649.2 → NP_001139121.1  zinc finger protein 529 isoform a

    See identical proteins and their annotated locations for NP_001139121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC092295, BC036578, BP279443, DA111996
    Consensus CDS
    CCDS54256.1
    UniProtKB/Swiss-Prot
    K7EKE1, Q6P280, Q9H731, Q9HCF7
    Conserved Domains (3) summary
    COG5048
    Location:392 → 544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:38 → 79
    KRAB; KRAB box

  2. NM_001145650.2 → NP_001139122.1  zinc finger protein 529 isoform b

    See identical proteins and their annotated locations for NP_001139122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC092295, BC036578, DA503147
    Conserved Domains (3) summary
    COG5048
    Location:374 → 526
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434 → 454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:20 → 61
    KRAB; KRAB box

  3. NM_001321351.2 → NP_001308280.1  zinc finger protein 529 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092295, AK025110, BX503547
    Consensus CDS
    CCDS82335.1
    UniProtKB/TrEMBL
    A0A0C4DFR4
    Related
    ENSP00000334695.7, ENST00000334116.7
    Conserved Domains (2) summary
    COG5048
    Location:287 → 439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347 → 367
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001352272.2 → NP_001339201.1  zinc finger protein 529 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092295, AK025110, BX503547
    Consensus CDS
    CCDS82335.1
    UniProtKB/TrEMBL
    A0A0C4DFR4
    Conserved Domains (2) summary
    COG5048
    Location:287 → 439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347 → 367
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001352273.2 → NP_001339202.1  zinc finger protein 529 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092295, AK025110, BX503547
    Consensus CDS
    CCDS82335.1
    UniProtKB/TrEMBL
    A0A0C4DFR4
    Conserved Domains (2) summary
    COG5048
    Location:287 → 439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347 → 367
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_020951.5 → NP_066002.3  zinc finger protein 529 isoform a

    See identical proteins and their annotated locations for NP_066002.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC092295, BC036578, BC064690, BX503547
    Consensus CDS
    CCDS54256.1
    UniProtKB/Swiss-Prot
    K7EKE1, Q6P280, Q9H731, Q9HCF7
    Related
    ENSP00000465578.1, ENST00000591340.6
    Conserved Domains (3) summary
    COG5048
    Location:392 → 544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:38 → 79
    KRAB; KRAB box

RNA

  1. NR_027239.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several 3' exons but includes an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks the coding region, as found in variant 1.
    Source sequence(s)
    AK091072, AK094618, AL109722, DA111996
    Related
    ENST00000586458.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36543613..36605543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527164.4 → XP_011525466.1  zinc finger protein 529 isoform X1

    See identical proteins and their annotated locations for XP_011525466.1

    UniProtKB/Swiss-Prot
    K7EKE1, Q6P280, Q9H731, Q9HCF7
    Conserved Domains (3) summary
    COG5048
    Location:392 → 544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:38 → 79
    KRAB; KRAB box

  2. XM_011527165.4 → XP_011525467.1  zinc finger protein 529 isoform X2

    See identical proteins and their annotated locations for XP_011525467.1

    Conserved Domains (3) summary
    COG5048
    Location:374 → 526
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434 → 454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:20 → 61
    KRAB; KRAB box

  3. XM_006723302.5 → XP_006723365.1  zinc finger protein 529 isoform X1

    See identical proteins and their annotated locations for XP_006723365.1

    UniProtKB/Swiss-Prot
    K7EKE1, Q6P280, Q9H731, Q9HCF7
    Conserved Domains (3) summary
    COG5048
    Location:392 → 544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:38 → 79
    KRAB; KRAB box

  4. XM_047439141.1 → XP_047295097.1  zinc finger protein 529 isoform X4

    UniProtKB/TrEMBL
    A0A0C4DFR4

  5. XM_047439140.1 → XP_047295096.1  zinc finger protein 529 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39218884..39280696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321570.1 → XP_054177545.1  zinc finger protein 529 isoform X1

    UniProtKB/Swiss-Prot
    K7EKE1, Q6P280, Q9H731, Q9HCF7

  2. XM_054321571.1 → XP_054177546.1  zinc finger protein 529 isoform X2

  3. XM_054321569.1 → XP_054177544.1  zinc finger protein 529 isoform X1

    UniProtKB/Swiss-Prot
    K7EKE1, Q6P280, Q9H731, Q9HCF7

  4. XM_054321573.1 → XP_054177548.1  zinc finger protein 529 isoform X4

    UniProtKB/TrEMBL
    A0A0C4DFR4

  5. XM_054321572.1 → XP_054177547.1  zinc finger protein 529 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P280.2 GenPept UniProtKB/Swiss-Prot:Q6P280

Gene LinkOut

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