U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PTPRA protein tyrosine phosphatase receptor type A [ Homo sapiens (human) ]

Gene ID: 5786, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PTPRAprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Aprovided by HGNC
Primary source
HGNC:HGNC:9664
See related
Ensembl:ENSG00000132670 MIM:176884; AllianceGenome:HGNC:9664
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 49.1), thyroid (RPKM 27.1) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
20p13
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (2864184..3038669)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (2895030..3069415)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2844830..3019315)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12607 Neighboring gene CRISPRi-validated cis-regulatory element chr20.196 Neighboring gene chromosome 20 open reading frame 141 Neighboring gene transmembrane protein 239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2812614-2813114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17472 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2820603-2821134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2821668-2822199 Neighboring gene PC-esterase domain containing 1A Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2840338-2840838 Neighboring gene VPS16 core subunit of CORVET and HOPS complexes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2852243-2852874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2852875-2853504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2853505-2854136 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2854137-2854766 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60029 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2903375-2903875 Neighboring gene Sharpr-MPRA regulatory region 1396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17473 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:3007535-3008734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17475 Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene gonadotropin releasing hormone 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation. Fang J, et al. Oncogene, 2023 Mar. PMID 36765146
  2. Does a rare mutation in PTPRA contribute to the development of Parkinson's disease in an Australian multi-incident family? Hill MA, et al. PLoS One, 2022. PMID 35900966, Free PMC Article
  3. RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. Wen Y, et al. J Biol Chem, 2020 Apr 10. PMID 32139509, Free PMC Article
  4. Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity. Xie X, et al. Nat Commun, 2020 Jan 10. PMID 31924785, Free PMC Article
  5. HePTP promotes migration and invasion in triple-negative breast cancer cells via activation of Wnt/β-catenin signaling. Yu L, et al. Biomed Pharmacother, 2019 Oct. PMID 31545274

See all (125) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glucose-mediated N-glycosylation of RPTPalpha affects its subcellular localization and Src activation.
    Title: Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation.
  2. Does a rare mutation in PTPRA contribute to the development of Parkinson's disease in an Australian multi-incident family?
    Title: Does a rare mutation in PTPRA contribute to the development of Parkinson's disease in an Australian multi-incident family?
  3. CircPTPRA blocks the recognition of RNA N(6)-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression.
    Title: CircPTPRA blocks the recognition of RNA N(6)-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression.
  4. Receptor-type protein tyrosine phosphatase alpha (PTPalpha) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion.
    Title: Receptor-type protein tyrosine phosphatase alpha (PTPα) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion.
  5. RPTPalpha phosphatase activity is allosterically regulated by the membrane-distal catalytic domain.
    Title: RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain.
  6. Filtered data from WES, combined with in silico analyses revealed a novel heterozygous missense variant (NM_080841:c.1730C>G:p.T577R; exon18) in Protein tyrosine phosphatase, receptor type A (PTPRA 20p13) in an Indian family with schizophrenia. Screening for variants in this gene in the WES data of an independent schizophrenia cohort (n=350) of matched ethnicity, identified five additional rare missense variants.
    Title: Rare variants in Protein tyrosine phosphatase, receptor type A (PTPRA) in schizophrenia: Evidence from a family based study.
  7. Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cell adhesion molecules involved in mediating neuronal development. The binding of LAR-RPTPs to extracellular ligands induces local clustering of LAR-RPTPs to regulate axon growth and synaptogenesis. LAR-RPTPs interact with synaptic liprin-alpha proteins via the two cytoplasmic phosphatase domains, D1 and D2.
    Title: Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity.
  8. miR-146a-5p may negatively regulate the PTPRA-SRC signaling to inhibit expression of fibrosis-related markers in irradiated and TGF-beta1-stimulated LX2 cells
    Title: MicroRNA-146a-5p Attenuates Fibrosis-related Molecules in Irradiated and TGF-beta1-Treated Human Hepatic Stellate Cells by Regulating PTPRA-SRC Signaling.
  9. HePTP plays a key role in the metastasis of triple-negative breast cancer via activating Wnt/beta-catenin signaling.
    Title: HePTP promotes migration and invasion in triple-negative breast cancer cells via activation of Wnt/β-catenin signaling.
  10. circPTPRA suppresses EMT and metastasis of NSCLC cell lines by sponging miR-96-5p, which upregulates the downstream tumor suppressor RASSF8.
    Title: The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
receptor-type tyrosine-protein phosphatase alpha
Names
Leukocyte common antigen-related peptide (protein tyrosine phosphate)
PTPLCA-related phosphatase
PTPase-alpha
protein tyrosine phosphatase, receptor type, alpha polypeptide
protein-tyrosine phosphatase alpha
tyrosine phosphatase alpha
NP_001372231.1
NP_001372232.1
NP_001372233.1
NP_001372234.1
NP_001372235.1
NP_001372236.1
NP_001372237.1
NP_001372239.1
NP_001372240.1
NP_001372241.1
NP_001372242.1
NP_001372243.1
NP_001372244.1
NP_001372245.1
NP_001372246.1
NP_001372247.1
NP_001372248.1
NP_001372249.1
NP_001372250.1
NP_001375249.1
NP_001375250.1
NP_001375251.1
NP_001375252.1
NP_001375253.1
NP_002827.1
NP_543030.1
NP_543031.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385302.1 → NP_001372231.1  receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    UniProtKB/TrEMBL
    B7Z2A4, E7ET72
    Conserved Domains (2) summary
    cd14621
    Location:225 → 520
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:574 → 801
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  2. NM_001385303.1 → NP_001372232.1  receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    UniProtKB/TrEMBL
    B7Z2A4, E7ET72
    Conserved Domains (2) summary
    cd14621
    Location:225 → 520
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:574 → 801
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  3. NM_001385304.1 → NP_001372233.1  receptor-type tyrosine-protein phosphatase alpha isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    UniProtKB/TrEMBL
    A0A1S5UZ22, B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:216 → 511
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:565 → 792
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  4. NM_001385305.1 → NP_001372234.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13038.1
    UniProtKB/Swiss-Prot
    A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
    UniProtKB/TrEMBL
    B7Z4Q5
    Related
    ENSP00000382787.2, ENST00000399903.7
    Conserved Domains (2) summary
    cd14621
    Location:214 → 509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563 → 790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  5. NM_001385306.1 → NP_001372235.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13038.1
    UniProtKB/Swiss-Prot
    A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:214 → 509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563 → 790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  6. NM_001385307.1 → NP_001372236.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13038.1
    UniProtKB/Swiss-Prot
    A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:214 → 509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563 → 790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  7. NM_001385308.1 → NP_001372237.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13038.1
    UniProtKB/Swiss-Prot
    A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:214 → 509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563 → 790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  8. NM_001385310.1 → NP_001372239.1  receptor-type tyrosine-protein phosphatase alpha isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:216 → 511
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:565 → 789
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  9. NM_001385311.1 → NP_001372240.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13039.1
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:205 → 500
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:554 → 781
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  10. NM_001385312.1 → NP_001372241.1  receptor-type tyrosine-protein phosphatase alpha isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:205 → 500
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:554 → 780
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  11. NM_001385313.1 → NP_001372242.1  receptor-type tyrosine-protein phosphatase alpha isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14623
    Location:464 → 691
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:270 → 389
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  12. NM_001385314.1 → NP_001372243.1  receptor-type tyrosine-protein phosphatase alpha isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14623
    Location:462 → 689
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:268 → 387
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  13. NM_001385315.1 → NP_001372244.1  receptor-type tyrosine-protein phosphatase alpha isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14623
    Location:453 → 680
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:259 → 378
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  14. NM_001385316.1 → NP_001372245.1  receptor-type tyrosine-protein phosphatase alpha isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:99 → 394
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:448 → 675
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  15. NM_001385317.1 → NP_001372246.1  receptor-type tyrosine-protein phosphatase alpha isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:91 → 386
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:440 → 667
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  16. NM_001385318.1 → NP_001372247.1  receptor-type tyrosine-protein phosphatase alpha isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    PHA02740
    Location:245 → 348
    PHA02740; protein tyrosine phosphatase; Provisional
    cd14623
    Location:424 → 651
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  17. NM_001385319.1 → NP_001372248.1  receptor-type tyrosine-protein phosphatase alpha isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    PHA02740
    Location:243 → 346
    PHA02740; protein tyrosine phosphatase; Provisional
    cd14623
    Location:422 → 649
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  18. NM_001385320.1 → NP_001372249.1  receptor-type tyrosine-protein phosphatase alpha isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    PHA02740
    Location:243 → 346
    PHA02740; protein tyrosine phosphatase; Provisional
    cd14623
    Location:422 → 649
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  19. NM_001385321.1 → NP_001372250.1  receptor-type tyrosine-protein phosphatase alpha isoform 14 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    PHA02740
    Location:234 → 337
    PHA02740; protein tyrosine phosphatase; Provisional
    cd14623
    Location:413 → 640
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  20. NM_001388320.1 → NP_001375249.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13038.1
    UniProtKB/Swiss-Prot
    A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:214 → 509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563 → 790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  21. NM_001388321.1 → NP_001375250.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13039.1
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:205 → 500
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:554 → 781
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  22. NM_001388322.1 → NP_001375251.1  receptor-type tyrosine-protein phosphatase alpha isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    UniProtKB/TrEMBL
    B7Z4F4
    Conserved Domains (2) summary
    cd14623
    Location:237 → 464
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:1 → 183
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  23. NM_001388323.1 → NP_001375252.1  receptor-type tyrosine-protein phosphatase alpha isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    UniProtKB/TrEMBL
    B7Z4F4
    Conserved Domains (2) summary
    cd14623
    Location:237 → 464
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:1 → 183
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  24. NM_001388324.1 → NP_001375253.1  receptor-type tyrosine-protein phosphatase alpha isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    UniProtKB/TrEMBL
    B7Z4F4
    Conserved Domains (2) summary
    cd14623
    Location:237 → 464
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:1 → 183
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  25. NM_002836.4 → NP_002827.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_002827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK090743, AL161656, BC027308, M34668
    Consensus CDS
    CCDS13038.1
    UniProtKB/Swiss-Prot
    A8K2G8, D3DVX5, P18433, Q14513, Q7Z2I2, Q96TD9
    UniProtKB/TrEMBL
    B7Z4Q5
    Conserved Domains (2) summary
    cd14621
    Location:214 → 509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563 → 790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  26. NM_080840.3 → NP_543030.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_543030.1

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13039.1
    UniProtKB/TrEMBL
    B7Z4Q5
    Related
    ENSP00000216877.6, ENST00000216877.10
    Conserved Domains (2) summary
    cd14621
    Location:205 → 500
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:554 → 781
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

  27. NM_080841.3 → NP_543031.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_543031.1

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13039.1
    UniProtKB/TrEMBL
    B7Z4Q5
    Related
    ENSP00000314568.5, ENST00000318266.9
    Conserved Domains (2) summary
    cd14621
    Location:205 → 500
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:554 → 781
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

RNA

  1. NR_170936.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    2864184..3038669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    2895030..3069415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18433.3 GenPept UniProtKB/Swiss-Prot:P18433

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous