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Hacd3 3-hydroxyacyl-CoA dehydratase 3 [ Mus musculus (house mouse) ]

Gene ID: 57874, updated on 2-Nov-2024

Summary

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Official Symbol
Hacd3provided by MGI
Official Full Name
3-hydroxyacyl-CoA dehydratase 3provided by MGI
Primary source
MGI:MGI:1889341
See related
Ensembl:ENSMUSG00000033629 AllianceGenome:MGI:1889341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hcad3; B-ind1; Hspc121; Ptplad1; 4930523M17Rik
Summary
Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Involved in negative regulation of intracellular signal transduction. Acts upstream of or within JNK cascade and Rho protein signal transduction. Predicted to be located in endoplasmic reticulum and nuclear membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal gland; central nervous system; gonad; retina; and tibialis anterior. Orthologous to human HACD3 (3-hydroxyacyl-CoA dehydratase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 48.9), ovary adult (RPKM 29.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hacd3 in Genome Data Viewer
Location:
9 C; 9 35.03 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64894265..64929014, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64986983..65021732, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 Neighboring gene predicted gene, 39361 Neighboring gene STARR-positive B cell enhancer ABC_E1789 Neighboring gene integrator complex subunit 14 Neighboring gene predicted gene, 25640 Neighboring gene STARR-positive B cell enhancer ABC_E9330 Neighboring gene predicted gene, 39362 Neighboring gene dipeptidylpeptidase 8 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts. Courilleau D, et al. J Biol Chem, 2000 Jun 9. PMID 10747961
  2. HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. Blondelle J, et al. J Mol Cell Biol, 2015 Oct. PMID 26160855, Free PMC Article
  3. Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. Olesen C, et al. Cell Tissue Res, 2007 Apr. PMID 17431699
  4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25483

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation by virus of viral protein levels in host cell IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation by virus of viral protein levels in host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
Names
butyrate-induced protein 1
butyrate-induced transcript 1
protein tyrosine phosphatase-like A domain containing 1
protein tyrosine phosphatase-like protein PTPLAD1
protein-tyrosine phosphatase-like A domain-containing protein 1
very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
NP_067320.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021345.2 → NP_067320.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3

    See identical proteins and their annotated locations for NP_067320.2

    Status: VALIDATED

    Source sequence(s)
    AK159494, CJ176979, CX209453
    Consensus CDS
    CCDS23284.1
    UniProtKB/Swiss-Prot
    O09003, Q6PGH3, Q8BGM8, Q8K2C9
    Related
    ENSMUSP00000044955.6, ENSMUST00000036615.7
    Conserved Domains (2) summary
    cd06465
    Location:8 → 115
    p23_hB-ind1_like; p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) ...
    pfam04387
    Location:195 → 352
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64894265..64929014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001778950.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2C9.2 GenPept UniProtKB/Swiss-Prot:Q8K2C9

Gene LinkOut

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