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Zfp318 zinc finger protein 318 [ Mus musculus (house mouse) ]

Gene ID: 57908, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp318provided by MGI
Official Full Name
zinc finger protein 318provided by MGI
Primary source
MGI:MGI:1889348
See related
Ensembl:ENSMUSG00000015597 AllianceGenome:MGI:1889348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TZF; Znf318; 2610034E08Rik; D530032D06Rik
Summary
Enables protein heterodimerization activity and protein homodimerization activity. Involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in central nervous system; early conceptus; reproductive system; and urinary system. Orthologous to human ZNF318 (zinc finger protein 318). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 4.1), CNS E18 (RPKM 3.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp318 in Genome Data Viewer
Location:
17 22.9 cM; 17 C
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46694444..46731846)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46383515..46420920)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene ATP-binding cassette, sub-family C member 10 Neighboring gene STARR-positive B cell enhancer ABC_E1943 Neighboring gene cDNA sequence BC040756 Neighboring gene predicted gene 9706 Neighboring gene cysteine-rich protein 3 Neighboring gene solute carrier family 22 (organic anion transporter), member 7 Neighboring gene predicted gene, 36541

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Abnormal spermatogenesis and male infertility in testicular zinc finger protein Zfp318-knockout mice. Ishizuka M, et al. Dev Growth Differ, 2016 Sep. PMID 27385512, Free PMC Article
  2. Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes. Enders A, et al. Proc Natl Acad Sci U S A, 2014 Mar 25. PMID 24616512, Free PMC Article
  3. The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. Inoue A, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873617
  4. Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis. Ishizuka M, et al. Biochem Biophys Res Commun, 2003 Feb 21. PMID 12589823
  5. Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus. Pioli PD, et al. J Immunol, 2014 Sep 1. PMID 25057009, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ampk regulates IgD expression but not energy stress with B cell activation.
    Title: Ampk regulates IgD expression but not energy stress with B cell activation.
  2. Zfp318 is expressed as a functional protein in testicular germ cells and plays an important role in meiosis during spermatogenesis.
    Title: Abnormal spermatogenesis and male infertility in testicular zinc finger protein Zfp318-knockout mice.
  3. This finding indicates that Zfp318, in a novel manner, functions by repressing recognition of the transcriptional termination site at the 3' end of the terminal IgM-encoding exon
    Title: Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus.
  4. findings identify ZFP318 as a crucial factor regulating the expression of the two major antibody isotypes on the surface of most mature B cells
    Title: Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.
  5. Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
    Title: Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
  6. in the unique regulation system of AR-mediated transactivation, two spliced isoforms of TZF act as coactivator and corepressor, respectively
    Title: Opposite effects of alternative TZF spliced variants on androgen receptor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 318
Names
testicular zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021346.2 → NP_067321.2  zinc finger protein 318 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC151275, CT009572
    Consensus CDS
    CCDS28826.2
    Related
    ENSMUSP00000116544.2, ENSMUST00000138127.8
    Conserved Domains (4) summary
    smart00451
    Location:1085 → 1114
    ZnF_U1; U1-like zinc finger
    pfam15087
    Location:18 → 127
    DUF4551; Protein of unknown function (DUF4551)
    cd16269
    Location:971 → 982
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:899 → 996
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_207671.4 → NP_997554.2  zinc finger protein 318 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC151275, AK157779, AW457229, BU704885, CD542244, CJ161473, CT009572
    Consensus CDS
    CCDS28827.2
    UniProtKB/Swiss-Prot
    B0V2M3, B9EK88, Q3TZL5, Q8BMX9, Q99PP2, Q9JJ01
    Related
    ENSMUSP00000109109.2, ENSMUST00000113481.9
    Conserved Domains (3) summary
    smart00451
    Location:1155 → 1189
    ZnF_U1; U1-like zinc finger
    cl26511
    Location:899 → 1031
    Neuromodulin_N; Gap junction protein N-terminal region
    cl28033
    Location:18 → 142
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46694444..46731846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246554.4 → XP_011244856.1  zinc finger protein 318 isoform X1

    Conserved Domains (2) summary
    PTZ00121
    Location:687 → 819
    PTZ00121; MAEBL; Provisional
    smart00451
    Location:943 → 977
    ZnF_U1; U1-like zinc finger

RNA

  1. XR_385351.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PP2.3 GenPept UniProtKB/Swiss-Prot:Q99PP2

Gene LinkOut

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