actc1b actin alpha cardiac muscle 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: actc1bprovided by ZNC
Official Full Name: actin alpha cardiac muscle 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000322-1
See related: Ensembl:ENSDARG00000099197 AllianceGenome:ZFIN:ZDB-GENE-000322-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: acta1; fa27h01; fb83f06; wu:fa27h01; wu:fb83f06
Summary: Predicted to be part of dynactin complex. Is expressed in several structures, including EVL; mesoderm; musculature system; pericardial region; and trunk. Used to study nemaline myopathy. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (117110..124665, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (117120..124675, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Persistent and polarized global actin flow is essential for directionality during cell migration.
Title: Persistent and polarized global actin flow is essential for directionality during cell migration.
Studies indicate that The change in F-actin or G-actin contents in a cell would translate to a number of biological endpoints such as change in cell shape, disrupted cell division, altered cell-cell adhesion, cell survival, and cell migration or motility.
Title: Disruption of blastomeric F-actin: a potential early biomarker of developmental toxicity in zebrafish.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA606111 (e-PCR)
- UniSTS:206868

fb23d02.x1 (e-PCR)
- UniSTS:190320

actin.AI416203 (e-PCR)
- UniSTS:205687

STS69.A6 (e-PCR)
- UniSTS:205701

LOC345651 (e-PCR)
- UniSTS:265879

fb83f06.x1 (e-PCR)
- UniSTS:203499

PMC117352P1 (e-PCR)
- UniSTS:270329

aa549815 (e-PCR)
- UniSTS:186875

Gene Ontology Provided by ZFIN

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: actin, alpha cardiac muscle 1b

Names: actin, alpha 1, skeletal muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.