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Sorcs1 sortilin-related VPS10 domain containing receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 58178, updated on 2-Nov-2024

Summary

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Official Symbol
Sorcs1provided by MGI
Official Full Name
sortilin-related VPS10 domain containing receptor 1provided by MGI
Primary source
MGI:MGI:1929666
See related
Ensembl:ENSMUSG00000043531 AllianceGenome:MGI:1929666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sorcs; mSorCS
Summary
Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be active in Golgi apparatus and membrane. Is expressed in several structures, including frenulum; genitourinary system; nervous system; sensory organ; and visual system. Orthologous to human SORCS1 (sortilin related VPS10 domain containing receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 3.5), cortex adult (RPKM 3.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Sorcs1 in Genome Data Viewer
Location:
19 D1; 19 45.05 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (50131733..50668030, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (50143295..50679129, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46394 Neighboring gene siah E3 ubiquitin protein ligase 1, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_46395 Neighboring gene STARR-seq mESC enhancer starr_46396 Neighboring gene ribosomal protein 13A, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_46397 Neighboring gene STARR-seq mESC enhancer starr_46398 Neighboring gene STARR-seq mESC enhancer starr_46399 Neighboring gene STARR-seq mESC enhancer starr_46400 Neighboring gene STARR-seq mESC enhancer starr_46401 Neighboring gene STARR-seq mESC enhancer starr_46402 Neighboring gene predicted gene, 26629 Neighboring gene STARR-seq mESC enhancer starr_46403 Neighboring gene STARR-seq mESC enhancer starr_46404 Neighboring gene STARR-seq mESC enhancer starr_46406 Neighboring gene predicted gene, 25644 Neighboring gene STARR-seq mESC enhancer starr_46409 Neighboring gene STARR-seq mESC enhancer starr_46410 Neighboring gene STARR-seq mESC enhancer starr_46411 Neighboring gene ribosomal protein L31, pseudogene 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transient expression of SorCS in developing telencephalic and mesencephalic structures of the mouse. Hermey G, et al. Neuroreport, 2001 Jan 22. PMID 11201086
  2. Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1. Knight EM, et al. Acta Neuropathol Commun, 2016 Feb 25. PMID 26916443, Free PMC Article
  3. Alternative splicing of murine SorCS leads to two forms of the receptor that differ completely in their cytoplasmic tails. Hermey G, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760602
  4. SORCS1 and SORCS3 control energy balance and orexigenic peptide production. Subkhangulova A, et al. EMBO Rep, 2018 Apr. PMID 29440124, Free PMC Article
  5. SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport. Hermey G, et al. J Neurochem, 2015 Oct. PMID 26119586

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SorCS1-mediated sorting in dendritic endosomes controls Nrxn axonal surface polarization required for proper synapse development and function.
    Title: SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.
  2. SorCS1 and SorLA expression were markedly reduced in the frontal cerebral cortex and to a minor extent in the hippocampus, whereas SorCS3 expression was solely reduced in the frontal cerebral cortex
    Title: Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice.
  3. our findings identified a novel role for VPS10P domain receptors SORCS1 and SORCS3 in hypothalamic control of metabolism through regulation of orexigenic peptide production.
    Title: SORCS1 and SORCS3 control energy balance and orexigenic peptide production.
  4. Male mice with either the APP/PSEN1 or Sorcs1 -/- genotype displayed earlier onset and persistent impairment in both glucose homeostasis and in learning behavior.
    Title: Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.
  5. SorCS1 and APP share trafficking pathways and that SorCS1c can retain APP from insertion into anterograde transport vesicles
    Title: SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport.
  6. SorCs1 is a global protein trafficking regulator, including AMPA receptors and neurexins.
    Title: The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.
  7. SORCS1 is sufficient to promote secretory granule biogenesis in metabolically stressed beta cells
    Title: SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.
  8. Different motifs regulate trafficking of Sorcs isoforms.
    Title: Different motifs regulate trafficking of SorCS1 isoforms.
  9. SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis
    Title: The three sorCS genes are differentially expressed and regulated by synaptic activity.
  10. identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus
    Title: Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in post-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
VPS10 domain-containing receptor SorCS1
Names
VPS10 domain receptor protein SORCS 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252501.2 → NP_001239430.1  VPS10 domain-containing receptor SorCS1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AC100726, AC101745, AC131103, AC158463
    Consensus CDS
    CCDS84452.1
    UniProtKB/TrEMBL
    A0A1B0GRC4, Q8BSV0
    Related
    ENSMUSP00000147463.2, ENSMUST00000209413.2
    Conserved Domains (3) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain
    pfam15901
    Location:638 → 793
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

  2. NM_001290356.2 → NP_001277285.1  VPS10 domain-containing receptor SorCS1 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC100726, AC101745, AC131103, AC158463
    Consensus CDS
    CCDS84451.1
    UniProtKB/TrEMBL
    A0A1B0GT94, Q1HL23
    Related
    ENSMUSP00000148254.2, ENSMUST00000209783.2
    Conserved Domains (2) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain

  3. NM_001360457.2 → NP_001347386.1  VPS10 domain-containing receptor SorCS1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC100726, AC101745, AC131103, AC158463
    UniProtKB/TrEMBL
    A0A1B0GRB7
    Conserved Domains (2) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain

  4. NM_021377.4 → NP_067352.2  VPS10 domain-containing receptor SorCS1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC100726, AC101745, AC131103, AC158463
    Consensus CDS
    CCDS84453.1
    UniProtKB/TrEMBL
    A0A1B0GRN1, Q1HL25
    Related
    ENSMUSP00000147591.2, ENSMUST00000211687.2
    Conserved Domains (3) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain
    pfam15901
    Location:638 → 793
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    50131733..50668030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251008.2 → XP_030106868.1  VPS10 domain-containing receptor SorCS1 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GRB7
    Conserved Domains (2) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 877
    PKD; PKD domain

  2. XM_017318265.3 → XP_017173754.1  VPS10 domain-containing receptor SorCS1 isoform X3

    Conserved Domains (2) summary
    smart00602
    Location:1 → 316
    VPS10; VPS10 domain
    pfam00801
    Location:330 → 400
    PKD; PKD domain

  3. XM_030251009.2 → XP_030106869.1  VPS10 domain-containing receptor SorCS1 isoform X2

    Conserved Domains (2) summary
    smart00602
    Location:1 → 316
    VPS10; VPS10 domain
    pfam00801
    Location:330 → 400
    PKD; PKD domain

  4. XM_006527243.3 → XP_006527306.1  VPS10 domain-containing receptor SorCS1 isoform X4

    Conserved Domains (2) summary
    smart00602
    Location:1 → 316
    VPS10; VPS10 domain
    pfam00801
    Location:330 → 400
    PKD; PKD domain

  5. XM_006527244.5 → XP_006527307.1  VPS10 domain-containing receptor SorCS1 isoform X5

    UniProtKB/TrEMBL
    A0A1B0GRB7
    Conserved Domains (2) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 877
    PKD; PKD domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLC4.1 GenPept UniProtKB/Swiss-Prot:Q9JLC4

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