U.S. flag

An official website of the United States government

TRAPPC1 trafficking protein particle complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 58485, updated on 4-Jan-2025

Summary

Official Symbol
TRAPPC1provided by HGNC
Official Full Name
trafficking protein particle complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:19894
See related
Ensembl:ENSG00000170043 MIM:610969; AllianceGenome:HGNC:19894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BET5; MUM2
Summary
This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in placenta (RPKM 52.2), lymph node (RPKM 50.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TRAPPC1 in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7930345..7931999, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7835773..7837427, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7833663..7835317, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7818325-7819258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8148 Neighboring gene ring finger protein 227 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11657 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7836395-7836572 Neighboring gene centrobin, centriole duplication and spindle assembly protein Neighboring gene MPRA-validated peak2715 silencer Neighboring gene guanylate cyclase 2D, retinal Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7920053-7920233

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of trafficking protein particle complex 1 (TRAPPC1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of TRAPP complex  
part_of TRAPPII protein complex PubMed 
part_of TRAPPIII protein complex PubMed 
located_in azurophil granule lumen  
located_in cytoplasm PubMed 
located_in cytosol  
located_in endoplasmic reticulum  
located_in extracellular region  

General protein information

Preferred Names
trafficking protein particle complex subunit 1
Names
BET5 homolog
MUM-2
melanoma ubiquitous mutated 2
multiple myeloma protein 2
trafficking protein particle complex 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166621.1NP_001160093.1  trafficking protein particle complex subunit 1

    See identical proteins and their annotated locations for NP_001160093.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC032717, BI600633, BM762006, BU687854
    Consensus CDS
    CCDS11125.1
    UniProtKB/Swiss-Prot
    D3DTR0, Q9Y5R8
    UniProtKB/TrEMBL
    B2RA50
    Related
    ENSP00000441130.1, ENST00000540486.5
    Conserved Domains (1) summary
    cd14855
    Location:4133
    TRAPPC1_MUM2; Trafficking protein particle complex subunit 1
  2. NM_021210.5NP_067033.1  trafficking protein particle complex subunit 1

    See identical proteins and their annotated locations for NP_067033.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104581, BC032717
    Consensus CDS
    CCDS11125.1
    UniProtKB/Swiss-Prot
    D3DTR0, Q9Y5R8
    UniProtKB/TrEMBL
    B2RA50
    Related
    ENSP00000302783.4, ENST00000303731.9
    Conserved Domains (1) summary
    cd14855
    Location:4133
    TRAPPC1_MUM2; Trafficking protein particle complex subunit 1

RNA

  1. NR_030684.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104581, AW964727, BC032717
  2. NR_030697.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104581, BI600633, BU687854, BU940685
    Related
    ENST00000571739.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7930345..7931999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7835773..7837427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.