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CREBZF CREB/ATF bZIP transcription factor [ Homo sapiens (human) ]

Gene ID: 58487, updated on 16-Apr-2024

Summary

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Official Symbol
CREBZFprovided by HGNC
Official Full Name
CREB/ATF bZIP transcription factorprovided by HGNC
Primary source
HGNC:HGNC:24905
See related
Ensembl:ENSG00000137504 MIM:606444; AllianceGenome:HGNC:24905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZF; SMILE
Summary
Enables identical protein binding activity. Involved in negative regulation of gene expression, epigenetic; regulation of transcription, DNA-templated; and response to virus. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 18.3), spleen (RPKM 18.1) and 25 other tissues See more
Orthologs
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Genomic context

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See CREBZF in Genome Data Viewer
Location:
11q14.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (85657990..85682863, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (85594499..85619547, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (85369034..85393906, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5365 Neighboring gene transmembrane protein 126B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5367 Neighboring gene transmembrane protein 126A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85383205-85383705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85396033-85396534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85396535-85397034 Neighboring gene coiled-coil domain containing 89 Neighboring gene synaptotagmin like 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:85472379-85473578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3822

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mechanism for the induction of cell death in ONS-76 medulloblastoma cells by Zhangfei/CREB-ZF. Bodnarchuk TW, et al. J Neurooncol, 2012 Sep. PMID 22798206
  2. SMILE silencing and PMA activation gene networks in HeLa cells: comparison with kidney transplantation gene networks. Racapé M, et al. J Cell Biochem, 2012 Jun. PMID 22134986
  3. Zhangfei, a novel regulator of the human nerve growth factor receptor, trkA. Valderrama X, et al. J Neurovirol, 2008 Oct. PMID 19016376
  4. The neuronal host cell factor-binding protein Zhangfei inhibits herpes simplex virus replication. Akhova O, et al. J Virol, 2005 Dec. PMID 16282471, Free PMC Article
  5. SMILE Downregulation during Melanogenesis Induces MITF Transcription in B16F10 Cells. Truong XT, et al. Int J Mol Sci, 2022 Dec 1. PMID 36499416, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate Insulin Resistance and Type 2 Diabetes.
    Title: Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate Insulin Resistance and Type 2 Diabetes.
  2. When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion.
    Title: When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion.
  3. Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
    Title: Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
  4. SMILE Downregulation during Melanogenesis Induces MITF Transcription in B16F10 Cells.
    Title: SMILE Downregulation during Melanogenesis Induces MITF Transcription in B16F10 Cells.
  5. Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis.
    Title: Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis.
  6. miRNAs as potential biomarkers for the progression of gastric cancer inhibit CREBZF and regulate migration of gastric adenocarcinoma cells.
    Title: miRNAs as potential biomarkers for the progression of gastric cancer inhibit CREBZF and regulate migration of gastric adenocarcinoma cells.
  7. Zhangfei/CREBZF stabilizes p53 and co-localizes with it in cellular nuclei; the bLZip domain of Zhangfei is required for its profound effects on cell growth and interaction with p53.
    Title: Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53.
  8. Zhangfei had a suppressive effect on most unfolded protein response genes.
    Title: Zhangfei/CREB-ZF - a potential regulator of the unfolded protein response.
  9. Results indicate that Ursodeoxycholic acid (UDCA) activates SMILE gene expression, which leads to repression of liver X receptor alpha (LXRalpha)-mediated hepatic lipogenic enzyme gene expression.
    Title: Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor SMILE.
  10. Our objective was to determine the molecular mechanisms by which Zhangfei influences medulloblastoma cell lines
    Title: Mechanism for the induction of cell death in ONS-76 medulloblastoma cells by Zhangfei/CREB-ZF.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ94018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATF6-mediated unfolded protein response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in integrated stress response signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
CREB/ATF bZIP transcription factor
Names
HCF-binding transcription factor Zhangfei
SHP-interacting leucine zipper protein
Zhangfei
host cell factor-binding transcription factor Zhangfei
small heterodimer partner-interacting leucine zipper

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039618.4 → NP_001034707.1  CREB/ATF bZIP transcription factor

    See identical proteins and their annotated locations for NP_001034707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AP000642
    Consensus CDS
    CCDS41697.1
    UniProtKB/Swiss-Prot
    B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
    Related
    ENSP00000433459.1, ENST00000527447.2
    Conserved Domains (1) summary
    cl21462
    Location:219 → 260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RNA

  1. NR_028024.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000642

  2. NR_028025.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000642

  3. NR_028026.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000642

  4. NR_028027.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks four alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000642

  5. NR_165399.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

  6. NR_165400.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642, KF511165

  7. NR_165401.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642, KF511165

  8. NR_165402.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

  9. NR_165403.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

  10. NR_165404.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

  11. NR_165405.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

  12. NR_165406.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

  13. NR_165407.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

  14. NR_165408.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

  15. NR_165409.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

  16. NR_165410.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

  17. NR_165411.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    85657990..85682863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018086.2 → XP_016873575.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0
    Conserved Domains (1) summary
    cl21462
    Location:219 → 260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  2. XM_047427377.1 → XP_047283333.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0

  3. XM_047427378.1 → XP_047283334.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0
    Related
    ENSP00000507358.1, ENST00000682836.1

  4. XM_047427376.1 → XP_047283332.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0

  5. XM_047427375.1 → XP_047283331.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0

  6. XM_017018090.2 → XP_016873579.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
    Conserved Domains (1) summary
    cl21462
    Location:219 → 260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  7. XM_047427379.1 → XP_047283335.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    B2R8Q9, Q0P5U9, Q52LT3, Q9NS37

  8. XM_017018088.2 → XP_016873577.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
    Conserved Domains (1) summary
    cl21462
    Location:219 → 260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  9. XM_017018089.2 → XP_016873578.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
    Conserved Domains (1) summary
    cl21462
    Location:219 → 260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  10. XM_006718642.4 → XP_006718705.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0
    Related
    ENSP00000435762.1, ENST00000525639.1
    Conserved Domains (1) summary
    cl21462
    Location:219 → 260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  11. XM_011545195.3 → XP_011543497.1  CREB/ATF bZIP transcription factor isoform X2

    See identical proteins and their annotated locations for XP_011543497.1

    UniProtKB/Swiss-Prot
    B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
    Related
    ENSP00000434281.1, ENST00000490820.2
    Conserved Domains (1) summary
    cl21462
    Location:219 → 260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    85594499..85619547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369568.1 → XP_054225543.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0

  2. XM_054369567.1 → XP_054225542.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0

  3. XM_054369574.1 → XP_054225549.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    B2R8Q9, Q0P5U9, Q52LT3, Q9NS37

  4. XM_054369571.1 → XP_054225546.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0

  5. XM_054369572.1 → XP_054225547.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0

  6. XM_054369573.1 → XP_054225548.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0

  7. XM_054369570.1 → XP_054225545.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0

  8. XM_054369569.1 → XP_054225544.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0

  9. XM_054369575.1 → XP_054225550.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    B2R8Q9, Q0P5U9, Q52LT3, Q9NS37

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021212.1: Suppressed sequence

    Description
    NM_021212.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NS37.2 GenPept UniProtKB/Swiss-Prot:Q9NS37

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