U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RPRD1B regulation of nuclear pre-mRNA domain containing 1B [ Homo sapiens (human) ]

Gene ID: 58490, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
RPRD1Bprovided by HGNC
Official Full Name
regulation of nuclear pre-mRNA domain containing 1Bprovided by HGNC
Primary source
HGNC:HGNC:16209
See related
Ensembl:ENSG00000101413 MIM:614694; AllianceGenome:HGNC:16209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K-H; CREPT; NET60; C20orf77; Kub5-Hera; dJ1057B20.2
Summary
Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in positive regulation of cell population proliferation; regulation of cell cycle process; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 7.4), lymph node (RPKM 7.2) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RPRD1B in Genome Data Viewer
Location:
20q11.23
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (38033746..38092364)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (39758090..39816692)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (36662148..36720766)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17853 Neighboring gene TELO2 interacting protein 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36661589-36662184 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36662185-36662780 Neighboring gene uncharacterized LOC124904898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17855 Neighboring gene uncharacterized LOC124904897 Neighboring gene Sharpr-MPRA regulatory region 13539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12896 Neighboring gene RNA, 7SL, cytoplasmic 237, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2618 Neighboring gene uncharacterized LOC124904899 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:36740455-36740954

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CREPT serves as a biomarker of poor survival in pancreatic ductal adenocarcinoma. Yang G, et al. Cell Oncol (Dordr), 2021 Apr. PMID 33125631
  2. RPRD1B is a potentially molecular target for diagnosis and prevention of human papillomavirus E6/E7 infection-induced cervical cancer: A case-control study. Wen N, et al. Asia Pac J Clin Oncol, 2021 Jun. PMID 32866332
  3. Overexpression of cell-cycle related and expression-elevated protein in tumor (CREPT) in malignant cervical cancer. Wen N, et al. J Int Med Res, 2020 Jan. PMID 31939329, Free PMC Article
  4. CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation. Zhang Y, et al. Oncogene, 2018 Jun. PMID 29563608, Free PMC Article
  5. Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil. Kuang YS, et al. World J Gastroenterol, 2018 Jan 28. PMID 29398868, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer.
    Title: Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer.
  2. Immunohistochemical expression levels of cyclin D1 and CREPT reflect the course and prognosis in oral precancerous lesions and squamous cell carcinoma.
    Title: Immunohistochemical expression levels of cyclin D1 and CREPT reflect the course and prognosis in oral precancerous lesions and squamous cell carcinoma.
  3. CREPT serves as a biomarker of poor survival in pancreatic ductal adenocarcinoma.
    Title: CREPT serves as a biomarker of poor survival in pancreatic ductal adenocarcinoma.
  4. CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner.
    Title: CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner.
  5. RPRD1B is a potentially molecular target for diagnosis and prevention of human papillomavirus E6/E7 infection-induced cervical cancer: A case-control study.
    Title: RPRD1B is a potentially molecular target for diagnosis and prevention of human papillomavirus E6/E7 infection-induced cervical cancer: A case-control study.
  6. CREPT is required for murine stem cell maintenance during intestinal regeneration.
    Title: CREPT is required for murine stem cell maintenance during intestinal regeneration.
  7. MiR-139-5p inhibits the proliferation of gastric cancer cells by targeting Regulation of Nuclear Pre-mRNA Domain Containing 1B.
    Title: MiR-139-5p inhibits the proliferation of gastric cancer cells by targeting Regulation of Nuclear Pre-mRNA Domain Containing 1B.
  8. Overexpression of cell-cycle related and expression-elevated protein in tumor (CREPT) in malignant cervical cancer.
    Title: Overexpression of cell-cycle related and expression-elevated protein in tumor (CREPT) in malignant cervical cancer.
  9. Crosstalk between RNA Pol II C-terminal domain acetylation and phosphorylation via RPRD1B protein and its isoforms has been reported.
    Title: Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
  10. these results demonstrate that CREPT exerts an oncogenic role in glioma and its expression is regulated by miR-596.
    Title: CREPT promotes glioma cell proliferation and invasion by activating Wnt/β-catenin pathway and is a novel target of microRNA-596.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ44520, DKFZp434P0735

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II C-terminal domain binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II promoter clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
regulation of nuclear pre-mRNA domain-containing protein 1B
Names
Ku70-binding protein 5-Hera
cell-cycle related and expression-elevated protein in tumor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021215.4 → NP_067038.1  regulation of nuclear pre-mRNA domain-containing protein 1B

    See identical proteins and their annotated locations for NP_067038.1

    Status: VALIDATED

    Source sequence(s)
    AK092567, BC033629, BP359144
    Consensus CDS
    CCDS13301.1
    UniProtKB/Swiss-Prot
    Q1WDE7, Q6PKF4, Q9NQG5
    Related
    ENSP00000362532.4, ENST00000373433.9
    Conserved Domains (2) summary
    cd17012
    Location:3 → 131
    CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
    pfam16566
    Location:178 → 324
    CREPT; Cell-cycle alteration and expression-elevated protein in tumor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    38033746..38092364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440346.1 → XP_047296302.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1

  2. XM_047440347.1 → XP_047296303.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X2

    Related
    ENSP00000416420.2, ENST00000449186.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    39758090..39816692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323787.1 → XP_054179762.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1

  2. XM_054323788.1 → XP_054179763.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NQG5.1 GenPept UniProtKB/Swiss-Prot:Q9NQG5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous