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DMRT3 doublesex and mab-3 related transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 58524, updated on 28-Oct-2024

Summary

Official Symbol
DMRT3provided by HGNC
Official Full Name
doublesex and mab-3 related transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:13909
See related
Ensembl:ENSG00000064218 MIM:614754; AllianceGenome:HGNC:13909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DMRTA3
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in male sex differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult walking behavior; regulation of odontogenesis of dentin-containing tooth; and ventral spinal cord interneuron specification. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in thyroid (RPKM 4.6), testis (RPKM 2.6) and 2 other tissues See more
Orthologs
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Genomic context

See DMRT3 in Genome Data Viewer
Location:
9p24.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (976655..991732)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (977925..992996)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (976655..991732)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28120 Neighboring gene doublesex and mab-3 related transcription factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28121 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:969074-969636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:970761-971321 Neighboring gene VISTA enhancer hs112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:975821-976322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:976323-976822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:981223-981729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19727 Neighboring gene RNA, U6 small nuclear 1073, pseudogene Neighboring gene H3 histone pseudogene 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC142144

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in male sex differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sex differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
 
involved_in ventral spinal cord interneuron specification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
doublesex- and mab-3-related transcription factor 3
Names
DMRT-like family A3
testis-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021240.4NP_067063.1  doublesex- and mab-3-related transcription factor 3

    See identical proteins and their annotated locations for NP_067063.1

    Status: VALIDATED

    Source sequence(s)
    AF193873, AI052121, AL136365, BC113584
    Consensus CDS
    CCDS6443.1
    UniProtKB/Swiss-Prot
    Q7LA03, Q7LCH8, Q96SC7, Q9NQL9, Q9NRQ9
    Related
    ENSP00000190165.2, ENST00000190165.3
    Conserved Domains (2) summary
    cd14419
    Location:247289
    CUE_DMA_DMRTA3; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3)
    pfam00751
    Location:2571
    DM; DM DNA binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    976655..991732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    977925..992996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)