U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ABRACL ABRA C-terminal like [ Homo sapiens (human) ]

Gene ID: 58527, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ABRACLprovided by HGNC
Official Full Name
ABRA C-terminal likeprovided by HGNC
Primary source
HGNC:HGNC:21230
See related
Ensembl:ENSG00000146386 AllianceGenome:HGNC:21230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Costars; HSPC280; PRO2013; C6orf115
Summary
Predicted to be involved in regulation of actin filament-based process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon (RPKM 38.5), lymph node (RPKM 36.1) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6q24.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (139028745..139043302)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (140215028..140231830)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (139349882..139364439)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene epithelial cell transforming 2 like Neighboring gene uncharacterized LOC107986650 Neighboring gene RALBP1 associated Eps domain containing 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:139298793-139299367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17602 Neighboring gene NANOG hESC enhancer GRCh37_chr6:139331747-139332499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17603 Neighboring gene Sharpr-MPRA regulatory region 12009 Neighboring gene Sharpr-MPRA regulatory region 5517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:139447769-139448270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25165 Neighboring gene Sharpr-MPRA regulatory region 4168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:139484703-139485202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25168 Neighboring gene hdc homolog, cell cycle regulator Neighboring gene taxilin beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:139563281-139563806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:139563807-139564332 Neighboring gene Sharpr-MPRA regulatory region 11439 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:139583345-139584544 Neighboring gene uncharacterized LOC102723690

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Human Costars Family Protein ABRACL Modulates Actin Dynamics and Cell Migration and Associates with Tumorigenic Growth. Hsiao BY, et al. Int J Mol Sci, 2021 Feb 18. PMID 33670794, Free PMC Article
  2. Solution structure of the human HSPC280 protein. Lin J, et al. Protein Sci, 2011 Jan. PMID 21082705, Free PMC Article
  3. Costars, a Dictyostelium protein similar to the C-terminal domain of STARS, regulates the actin cytoskeleton and motility. Pang TL, et al. J Cell Sci, 2010 Nov 1. PMID 20940261
  4. A proteomic analysis of human hemodialysis fluid. Molina H, et al. Mol Cell Proteomics, 2005 May. PMID 15723814
  5. Actin-binding Rho activating C-terminal like (ABRACL) transcriptionally regulated by MYB proto-oncogene like 2 (MYBL2) promotes the proliferation, invasion, migration and epithelial-mesenchymal transition of breast cancer cells. Li J, et al. Bioengineered, 2022 Apr. PMID 35341461, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Actin-binding Rho activating C-terminal like (ABRACL) transcriptionally regulated by MYB proto-oncogene like 2 (MYBL2) promotes the proliferation, invasion, migration and epithelial-mesenchymal transition of breast cancer cells.
    Title: Actin-binding Rho activating C-terminal like (ABRACL) transcriptionally regulated by MYB proto-oncogene like 2 (MYBL2) promotes the proliferation, invasion, migration and epithelial-mesenchymal transition of breast cancer cells.
  2. miR-145-5p Inhibits the Proliferation, Migration, and Invasion of Esophageal Carcinoma Cells by Targeting ABRACL.
    Title: miR-145-5p Inhibits the Proliferation, Migration, and Invasion of Esophageal Carcinoma Cells by Targeting ABRACL.
  3. Human Costars Family Protein ABRACL Modulates Actin Dynamics and Cell Migration and Associates with Tumorigenic Growth.
    Title: Human Costars Family Protein ABRACL Modulates Actin Dynamics and Cell Migration and Associates with Tumorigenic Growth.
  4. Solution structure of the human HSPC280 protein
    Title: Solution structure of the human HSPC280 protein.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of actin filament-based process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
costars family protein ABRACL
Names
ABRA C-terminal-like protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021243.3 → NP_067066.1  costars family protein ABRACL

    See identical proteins and their annotated locations for NP_067066.1

    Status: VALIDATED

    Source sequence(s)
    AF116682, BG563686
    Consensus CDS
    CCDS43509.1
    UniProtKB/Swiss-Prot
    Q5SZC8, Q9P0A1, Q9P1F3
    Related
    ENSP00000356632.3, ENST00000367660.4
    Conserved Domains (1) summary
    pfam14705
    Location:2 → 78
    Costars

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    139028745..139043302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419197.1 → XP_047275153.1  costars family protein ABRACL isoform X1

  2. XM_017011151.2 → XP_016866640.1  costars family protein ABRACL isoform X2

    UniProtKB/Swiss-Prot
    Q5SZC8, Q9P0A1, Q9P1F3
    Conserved Domains (1) summary
    pfam14705
    Location:2 → 78
    Costars

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    140215028..140231830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356129.1 → XP_054212104.1  costars family protein ABRACL isoform X2

    UniProtKB/Swiss-Prot
    Q5SZC8, Q9P0A1, Q9P1F3

  2. XM_054356130.1 → XP_054212105.1  costars family protein ABRACL isoform X2

    UniProtKB/Swiss-Prot
    Q5SZC8, Q9P0A1, Q9P1F3

  3. XM_054356128.1 → XP_054212103.1  costars family protein ABRACL isoform X2

    UniProtKB/Swiss-Prot
    Q5SZC8, Q9P0A1, Q9P1F3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P1F3.1 GenPept UniProtKB/Swiss-Prot:Q9P1F3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous