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Mapk6 mitogen-activated protein kinase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58840, updated on 2-Nov-2024

Summary

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Official Symbol
Mapk6provided by RGD
Official Full Name
mitogen-activated protein kinase 6provided by RGD
Primary source
RGD:62087
See related
EnsemblRapid:ENSRNOG00000009381 AllianceGenome:RGD:62087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ERK3
Summary
Predicted to enable MAP kinase activity; protein heterodimerization activity; and protein kinase binding activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within positive regulation of dendritic spine development. Predicted to be located in cytosol and septin cytoskeleton. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK6 (mitogen-activated protein kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 315.1), Testes (RPKM 287.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mapk6 in Genome Data Viewer
Location:
8q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (85027141..85050236, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (76146650..76169767, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (82328013..82351108, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 5 Neighboring gene Bcl2-like 10 Neighboring gene uncharacterized LOC102551227 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TGF-β1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6. Wang R, et al. Cell Tissue Res, 2021 Apr. PMID 33404840
  2. A novel mechanism for mitogen-activated protein kinase localization. Bind E, et al. Mol Biol Cell, 2004 Oct. PMID 15269285, Free PMC Article
  3. Effects of miR-26a-5p on neuropathic pain development by targeting MAPK6 in in CCI rat models. Zhang Y, et al. Biomed Pharmacother, 2018 Nov. PMID 30118880
  4. ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion. Anhê GF, et al. Mol Cell Endocrinol, 2006 Jun 7. PMID 16597486
  5. MicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia. Tan J, et al. Sci Rep, 2017 Apr 21. PMID 28429763, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TGF-beta1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6.
    Title: TGF-β1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6.
  2. analysis revealed that the effects of miR-26a in VSMCs were mediated by targeting MAPK6 at the mRNA and protein levels.
    Title: MicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia.
  3. miR-26a-5p could act as a negative regulator of neuropathic pain development through targeting MAPK6
    Title: Effects of miR-26a-5p on neuropathic pain development by targeting MAPK6 in in CCI rat models.
  4. Thsi study validated the Hprt1, Actb, Mapk6 or B2m and showed that any one or combination of two of them are good reference genes for normalization of mRNA expression in qPCR experiments in the spinal cord and RVM in the CFA model of inflammatory injury.
    Title: Validation of four reference genes for quantitative mRNA expression studies in a rat model of inflammatory injury.
  5. It plays distinct role in proliferation, differentiation, and neuronal viability.
    Title: Role of ERK1, 2, and 5 in dopamine neuron survival during aging.
  6. These data suggest a novel mechanism for the localization of an MAPK family member, ERK3, in which cell cycle-regulated, site-specific proteolysis generates the nuclear form of the protein.
    Title: A novel mechanism for mitogen-activated protein kinase localization.
  7. ERK3 biological activity is regulated by its cellular abundance through the control of protein stability
    Title: Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.
  8. MAP2 is involved in ERK3 mediated insulin secretion
    Title: ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124957

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in septin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 6
Names
ERK-3
MAP kinase 6
MAPK 6
extracellular signal-regulated kinase 3
p55-MAPK
NP_113810.2
XP_006243471.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031622.2 → NP_113810.2  mitogen-activated protein kinase 6

    See identical proteins and their annotated locations for NP_113810.2

    Status: VALIDATED

    Source sequence(s)
    BC109380, BE104187, CB742965
    UniProtKB/Swiss-Prot
    P27704, Q32LY4
    UniProtKB/TrEMBL
    A6I1C7
    Related
    ENSRNOP00000013053.3, ENSRNOT00000013053.8
    Conserved Domains (2) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    smart00220
    Location:20 → 316
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    85027141..85050236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243409.5 → XP_006243471.1  mitogen-activated protein kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006243471.1

    UniProtKB/Swiss-Prot
    P27704, Q32LY4
    UniProtKB/TrEMBL
    A6I1C7
    Conserved Domains (2) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    smart00220
    Location:20 → 316
    S_TKc; Serine/Threonine protein kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27704.2 GenPept UniProtKB/Swiss-Prot:P27704

Gene LinkOut

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