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Tssk3 testis-specific serine kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 58864, updated on 2-Nov-2024

Summary

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Official Symbol
Tssk3provided by MGI
Official Full Name
testis-specific serine kinase 3provided by MGI
Primary source
MGI:MGI:1929914
See related
Ensembl:ENSMUSG00000000411 AllianceGenome:MGI:1929914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsk-3; Stk22c; Stk22d; Tssk-3; Tssk3b; 1700014N07Rik; 4930594I21Rik
Summary
Enables magnesium ion binding activity; manganese ion binding activity; and protein serine/threonine kinase activity. Involved in spermatid development. Is active in sperm flagellum. Is expressed in germ cell of testis; spermatid; spermatocyte; and testis. Orthologous to human TSSK3 (testis specific serine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 112.4) See more
Orthologs
human all
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Genomic context

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See Tssk3 in Genome Data Viewer
Location:
4 D2.2; 4 63.26 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129382801..129385523, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129489008..129491730, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129138525-129138708 Neighboring gene predicted gene, 24621 Neighboring gene BSD domain containing 1 Neighboring gene family with sequence similarity 229, member A Neighboring gene STARR-positive B cell enhancer ABC_E6223 Neighboring gene STARR-seq mESC enhancer starr_11499 Neighboring gene MARCKS-like 1 Neighboring gene histone deacetylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1039

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility. Nozawa K, et al. Andrology, 2023 Jul. PMID 36306217, Free PMC Article
  2. TSSK3, a novel target for male contraception, is required for spermiogenesis. Nayyab S, et al. Mol Reprod Dev, 2021 Nov. PMID 34623009, Free PMC Article
  3. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. Visconti PE, et al. Genomics, 2001 Oct. PMID 11597141
  4. Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. Bucko-Justyna M, et al. FEBS J, 2005 Dec. PMID 16336268
  5. A novel member of the testis specific serine kinase family, tssk-3, expressed in the Leydig cells of sexually mature mice. Zuercher G, et al. Mech Dev, 2000 May. PMID 10781952

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility.
    Title: Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility.
  2. PDK1-induced phosphorylation increased in vitro TSSK3 kinase activity, suggesting that TSSK3 can be regulated in the same way as AGC kinase family members. The peptide sequence RRSSSY containing Ser5 is identified as a target for TSSK3 phosphorylation
    Title: Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sperm capacitation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
testis-specific serine/threonine-protein kinase 3
Names
serine/threonine kinase 22C (spermiogenesis associated)
serine/threonine-protein kinase 22C
spermiogenesis associated serine/threonine kinase 22D
testis-specific kinase 3
testis-specific serine/threonine kinase 3b
NP_536690.1
XP_006503317.1
XP_030109549.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080442.2 → NP_536690.1  testis-specific serine/threonine-protein kinase 3

    See identical proteins and their annotated locations for NP_536690.1

    Status: VALIDATED

    Source sequence(s)
    AK019840
    Consensus CDS
    CCDS18693.1
    UniProtKB/Swiss-Prot
    Q9D2E1, Q9JL98
    Related
    ENSMUSP00000000421.6, ENSMUST00000000421.6
    Conserved Domains (1) summary
    cd14163
    Location:9 → 265
    STKc_TSSK3-like; Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129382801..129385523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253689.1 → XP_030109549.1  testis-specific serine/threonine-protein kinase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9D2E1, Q9JL98
    Conserved Domains (1) summary
    cd14163
    Location:9 → 265
    STKc_TSSK3-like; Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins

  2. XM_006503254.4 → XP_006503317.1  testis-specific serine/threonine-protein kinase 3 isoform X2

    See identical proteins and their annotated locations for XP_006503317.1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 190
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2E1.1 GenPept UniProtKB/Swiss-Prot:Q9D2E1

Gene LinkOut

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