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Hibadh 3-hydroxyisobutyrate dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 58875, updated on 3-Nov-2024

Summary

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Official Symbol
Hibadhprovided by MGI
Official Full Name
3-hydroxyisobutyrate dehydrogenaseprovided by MGI
Primary source
MGI:MGI:1889802
See related
Ensembl:ENSMUSG00000029776 AllianceGenome:MGI:1889802
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6430402H10Rik
Summary
Predicted to enable 3-hydroxyisobutyrate dehydrogenase activity. Predicted to be involved in valine catabolic process. Located in mitochondrion. Is expressed in several structures, including genitourinary system; gut; limb mesenchyme; liver and biliary system; and nervous system. Orthologous to human HIBADH (3-hydroxyisobutyrate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 114.2), liver adult (RPKM 95.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Hibadh in Genome Data Viewer
Location:
6 B3; 6 25.6 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52523215..52617285, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52546230..52640300, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1524 Neighboring gene ribosomal protein L38 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15904 Neighboring gene VISTA enhancer mm48 Neighboring gene RIKEN cDNA 1700094M24 gene Neighboring gene STARR-seq mESC enhancer starr_15905 Neighboring gene predicted gene, 33047 Neighboring gene STARR-seq mESC enhancer starr_15906 Neighboring gene STARR-seq mESC enhancer starr_15907 Neighboring gene STARR-positive B cell enhancer ABC_E536 Neighboring gene predicted gene, 24355 Neighboring gene STARR-positive B cell enhancer ABC_E8104 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication. Lehoczky JA, et al. Evol Dev, 2004 Nov-Dec. PMID 15509224
  2. A gene expression resource generated by genome-wide lacZ profiling in the mouse. Tuck E, et al. Dis Model Mech, 2015 Nov. PMID 26398943, Free PMC Article
  3. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article
  4. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
  5. The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3. Sánchez-Bellver L, et al. Int J Mol Sci, 2022 Oct 19. PMID 36293380, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-hydroxyisobutyrate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyisobutyrate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3-hydroxyisobutyrate dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in valine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in valine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in valine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
3-hydroxyisobutyrate dehydrogenase, mitochondrial
NP_663542.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145567.1 → NP_663542.1  3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_663542.1

    Status: PROVISIONAL

    Source sequence(s)
    BC003914
    Consensus CDS
    CCDS20151.1
    UniProtKB/Swiss-Prot
    Q8BJY2, Q99L13
    UniProtKB/TrEMBL
    A0ZNJ2
    Related
    ENSMUSP00000031788.9, ENSMUST00000031788.9
    Conserved Domains (3) summary
    TIGR01692
    Location:43 → 330
    HIBADH; 3-hydroxyisobutyrate dehydrogenase
    pfam03446
    Location:38 → 199
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
    pfam14833
    Location:202 → 329
    NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    52523215..52617285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99L13.1 GenPept UniProtKB/Swiss-Prot:Q99L13

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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