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Nme6 NME/NM23 nucleoside diphosphate kinase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58964, updated on 2-Nov-2024

Summary

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Official Symbol
Nme6provided by RGD
Official Full Name
NME/NM23 nucleoside diphosphate kinase 6provided by RGD
Primary source
RGD:61896
See related
EnsemblRapid:ENSRNOG00000020721 AllianceGenome:RGD:61896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nm23-R6
Summary
Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of cell growth and negative regulation of mitotic nuclear division. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 47.8), Heart (RPKM 44.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nme6 in Genome Data Viewer
Location:
8q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118708092..118717756)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109832085..109839301)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117920912..117928148)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6C, pseudogene 2 Neighboring gene F-box and WD repeat domain containing 12 Neighboring gene serine peptidase inhibitor, Kazal type 8 Neighboring gene cathelicidin antimicrobial peptide Neighboring gene cell division cycle 25A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis. Tsuiki H, et al. J Cell Biochem, 1999 Dec. PMID 10618642
  2. NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. Mehus JG, et al. Hum Genet, 1999 Jun. PMID 10453732
  3. The human Nm23/nucleoside diphosphate kinases. Lacombe ML, et al. J Bioenerg Biomembr, 2000 Jun. PMID 11768308
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside diphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleoside diphosphate kinase 6
Names
NDK 6
NDP kinase 6
expressed in non-metastatic cells 6 (nucleoside-diphosphate kinase)
expressed in non-metastatic cells 6, protein (nucleoside diphosphate kinase)
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
nucleoside diphosphate kinase type 6
NP_001178813.1
XP_006243909.1
XP_006243910.1
XP_006243911.1
XP_006243912.1
XP_006243913.1
XP_017451369.1
XP_038937966.1
XP_038937967.1
XP_038937969.1
XP_063122119.1
XP_063122120.1
XP_063122121.1
XP_063122122.1
XP_063122123.1
XP_063122125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191884.2 → NP_001178813.1  nucleoside diphosphate kinase 6

    See identical proteins and their annotated locations for NP_001178813.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    O88426
    UniProtKB/TrEMBL
    A6I3C2, R9PXW5
    Conserved Domains (2) summary
    smart00562
    Location:12 → 149
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04414
    Location:12 → 146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...

  2. NM_001431584.1 → NP_001418513.1  nucleoside diphosphate kinase 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I3C2, R9PXW5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118708092..118717756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243849.3 → XP_006243911.1  nucleoside diphosphate kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006243911.1

    UniProtKB/Swiss-Prot
    O88426
    UniProtKB/TrEMBL
    A6I3C2, R9PXW5
    Conserved Domains (2) summary
    smart00562
    Location:12 → 149
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04414
    Location:12 → 146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...

  2. XM_006243848.5 → XP_006243910.1  nucleoside diphosphate kinase 6 isoform X1

    Conserved Domains (2) summary
    smart00562
    Location:12 → 149
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04414
    Location:12 → 146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...

  3. XM_063266051.1 → XP_063122121.1  nucleoside diphosphate kinase 6 isoform X2

    UniProtKB/TrEMBL
    A6I3C3

  4. XM_006243847.5 → XP_006243909.1  nucleoside diphosphate kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006243909.1

    UniProtKB/Swiss-Prot
    O88426
    UniProtKB/TrEMBL
    A6I3C2, R9PXW5
    Conserved Domains (2) summary
    smart00562
    Location:12 → 149
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04414
    Location:12 → 146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...

  5. XM_063266050.1 → XP_063122120.1  nucleoside diphosphate kinase 6 isoform X2

    UniProtKB/TrEMBL
    A6I3C3

  6. XM_039082039.2 → XP_038937967.1  nucleoside diphosphate kinase 6 isoform X2

    UniProtKB/Swiss-Prot
    O88426
    UniProtKB/TrEMBL
    A6I3C3
    Conserved Domains (1) summary
    cl00335
    Location:1 → 101
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

  7. XM_063266049.1 → XP_063122119.1  nucleoside diphosphate kinase 6 isoform X2

    UniProtKB/TrEMBL
    A6I3C3

  8. XM_039082038.2 → XP_038937966.1  nucleoside diphosphate kinase 6 isoform X2

    UniProtKB/Swiss-Prot
    O88426
    UniProtKB/TrEMBL
    A6I3C3
    Conserved Domains (1) summary
    cl00335
    Location:1 → 101
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

  9. XM_006243850.5 → XP_006243912.1  nucleoside diphosphate kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006243912.1

    UniProtKB/Swiss-Prot
    O88426
    UniProtKB/TrEMBL
    A6I3C2, R9PXW5
    Conserved Domains (2) summary
    smart00562
    Location:12 → 149
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04414
    Location:12 → 146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...

  10. XM_063266055.1 → XP_063122125.1  nucleoside diphosphate kinase 6 isoform X2

    UniProtKB/TrEMBL
    A6I3C3

  11. XM_039082041.2 → XP_038937969.1  nucleoside diphosphate kinase 6 isoform X2

    UniProtKB/Swiss-Prot
    O88426
    UniProtKB/TrEMBL
    A6I3C3
    Conserved Domains (1) summary
    cl00335
    Location:1 → 101
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

  12. XM_006243851.4 → XP_006243913.1  nucleoside diphosphate kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006243913.1

    UniProtKB/Swiss-Prot
    O88426
    UniProtKB/TrEMBL
    A6I3C2, R9PXW5
    Related
    ENSRNOP00000028125.6, ENSRNOT00000028125.9
    Conserved Domains (2) summary
    smart00562
    Location:12 → 149
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04414
    Location:12 → 146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...

  13. XM_063266053.1 → XP_063122123.1  nucleoside diphosphate kinase 6 isoform X2

    UniProtKB/TrEMBL
    A6I3C3

  14. XM_063266052.1 → XP_063122122.1  nucleoside diphosphate kinase 6 isoform X2

    UniProtKB/TrEMBL
    A6I3C3

  15. XM_017595880.3 → XP_017451369.1  nucleoside diphosphate kinase 6 isoform X2

    UniProtKB/Swiss-Prot
    O88426
    UniProtKB/TrEMBL
    A6I3C3
    Conserved Domains (1) summary
    cl00335
    Location:1 → 101
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88426.1 GenPept UniProtKB/Swiss-Prot:O88426

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