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Rabggta Rab geranylgeranyltransferase subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 58983, updated on 14-Nov-2024

Summary

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Official Symbol
Rabggtaprovided by RGD
Official Full Name
Rab geranylgeranyltransferase subunit alphaprovided by RGD
Primary source
RGD:621697
See related
EnsemblRapid:ENSRNOG00000030483 AllianceGenome:RGD:621697
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables Rab geranylgeranyltransferase activity and small GTPase binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 81.2), Heart (RPKM 75.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rabggta in Genome Data Viewer
Location:
15p13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33176268..33183320, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29206328..29213398, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34393419..34400466, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase 2 Neighboring gene TERF1 interacting nuclear factor 2 Neighboring gene transglutaminase 1 Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 2 Neighboring gene dehydrogenase/reductase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells. Arora DK, et al. Islets, 2012 Sep-Oct. PMID 23114750, Free PMC Article
  2. Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Guo Z, et al. Angew Chem Int Ed Engl, 2008. PMID 18399557
  3. Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution. Zhang H, et al. Structure, 2000 Mar 15. PMID 10745007
  4. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. Guo Z, et al. EMBO J, 2008 Sep 17. PMID 18756270, Free PMC Article
  5. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. Armstrong SA, et al. J Biol Chem, 1993 Jun 5. PMID 8505342

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Rab geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Rab geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rab geranylgeranyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prenylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein geranylgeranylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein geranylgeranylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rab-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
geranylgeranyl transferase type-2 subunit alpha
Names
Rab geranylgeranyl transferase, a subunit
Rab geranylgeranyltransferase alpha
Rab geranylgeranyltransferase, alpha subunit
geranylgeranyl transferase type II subunit alpha
rab GG transferase alpha
rab GGTase alpha
rab geranyl-geranyltransferase subunit alpha
NP_113842.1
XP_006252071.1
XP_006252072.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031654.2 → NP_113842.1  geranylgeranyl transferase type-2 subunit alpha

    See identical proteins and their annotated locations for NP_113842.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086547
    UniProtKB/Swiss-Prot
    Q08602
    UniProtKB/TrEMBL
    A0A8I6GJ12, A6KH43
    Related
    ENSRNOP00000091502.2, ENSRNOT00000108610.2
    Conserved Domains (4) summary
    sd00031
    Location:443 → 461
    LRR_1; leucine-rich repeat [structural motif]
    pfam07711
    Location:247 → 346
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    cd21340
    Location:444 → 547
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl40684
    Location:1 → 237
    PPTA; Protein prenyltransferase alpha subunit repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    33176268..33183320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252010.5 → XP_006252072.1  geranylgeranyl transferase type-2 subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006252072.1

    UniProtKB/Swiss-Prot
    Q08602
    UniProtKB/TrEMBL
    A0A8I6GJ12, A6KH43
    Related
    ENSRNOP00000049261.5, ENSRNOT00000048455.6
    Conserved Domains (4) summary
    sd00031
    Location:443 → 461
    LRR_1; leucine-rich repeat [structural motif]
    pfam07711
    Location:247 → 346
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    cd21340
    Location:444 → 547
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl40684
    Location:1 → 237
    PPTA; Protein prenyltransferase alpha subunit repeat

  2. XM_006252009.5 → XP_006252071.1  geranylgeranyl transferase type-2 subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006252071.1

    UniProtKB/Swiss-Prot
    Q08602
    UniProtKB/TrEMBL
    A0A8I6GJ12, A6KH43
    Conserved Domains (4) summary
    sd00031
    Location:443 → 461
    LRR_1; leucine-rich repeat [structural motif]
    pfam07711
    Location:247 → 346
    RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
    cd21340
    Location:444 → 547
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl40684
    Location:1 → 237
    PPTA; Protein prenyltransferase alpha subunit repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08602.1 GenPept UniProtKB/Swiss-Prot:Q08602

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