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Huwe1 HECT, UBA and WWE domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 59026, updated on 2-Nov-2024

Summary

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Official Symbol
Huwe1provided by MGI
Official Full Name
HECT, UBA and WWE domain containing 1provided by MGI
Primary source
MGI:MGI:1926884
See related
Ensembl:ENSMUSG00000025261 AllianceGenome:MGI:1926884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mule; Ib772; LASU1; Ureb1; Gm1718; Arf-bp1; 5430439H10Rik; C430014N20Rik
Summary
Predicted to enable DNA binding activity and histone ubiquitin ligase activity. Involved in circadian regulation of gene expression and positive regulation of protein ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in Golgi membrane and nucleus. Is expressed in several structures, including extraembryonic component. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 24.1), CNS E14 (RPKM 22.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Huwe1 in Genome Data Viewer
Location:
X F3; X 68.46 cM
Exon count:
89
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (150583779..150718413)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (151800785..151935417)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48087 Neighboring gene nuclear encoded rRNA 5S 13 Neighboring gene STARR-positive B cell enhancer ABC_E2539 Neighboring gene tubulin tyrosine ligase-like 1 pseudogene Neighboring gene microRNA 3113 Neighboring gene STARR-seq mESC enhancer starr_48088 Neighboring gene microRNA let7f-2 Neighboring gene microRNA 98 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene hydroxysteroid (17-beta) dehydrogenase 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions. Wang L, et al. Diabetologia, 2014 Sep. PMID 24981769
  2. Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response. Fok KL, et al. Endocrinology, 2017 Nov 1. PMID 28938460
  3. Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis. Bose R, et al. Sci Rep, 2017 Dec 19. PMID 29259204, Free PMC Article
  4. Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum. D'Arca D, et al. Proc Natl Acad Sci U S A, 2010 Mar 30. PMID 20231446, Free PMC Article
  5. Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury. Wu Y, et al. Cell Death Differ, 2022 Sep. PMID 35260822, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life.
    Title: Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life.
  2. Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury.
    Title: Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury.
  3. [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis].
    Title: [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis].
  4. BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells.
    Title: BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells.
  5. HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection.
    Title: HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection.
  6. The functions of Huwe1 in spermatogenesis.
    Title: Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis.
  7. Mule-mediated ubiquitination of the novel substrate KLF4 regulates T-cell proliferation, autoimmunity and antiviral immune responses.
    Title: K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.
  8. The data supports an indispensable role for Mule in cardiac homeostasis through the regulation of mitochondrial function via maintenance of Pgc-1alpha and Pink1 expression and persistent negative regulation of c-Myc.
    Title: The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.
  9. these results suggest that HUWE1 protein could contribute to preimplantation embryo development and dysregulated expression of HUWE1 could be related to poor embryo development and miscarriage in IVF clinic.
    Title: HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans.
  10. Mule interacts directly with beta-catenin and targets it for degradation under conditions of hyperactive Wnt signaling, suggesting that Mule uses various mechanisms to fine-tune the Wnt pathway and provides multiple safeguards against tumorigenesis.
    Title: E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (3) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone ubiquitin ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in base-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type 2 mitophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HUWE1
Names
E3Histone
HECT, UBA and WWE domain-containing protein 1
HECT-type E3 ubiquitin transferase HUWE1
Mcl-1 ubiquitin ligase
URE-B1
URE-binding protein 1
upstream regulatory element binding protein 1
NP_067498.4
XP_006528996.1
XP_006528997.1
XP_006528999.1
XP_006529000.1
XP_006529001.1
XP_006529002.1
XP_006529003.1
XP_006529006.1
XP_006529011.1
XP_006529012.1
XP_006529014.1
XP_011246154.1
XP_030107294.1
XP_030107295.1
XP_030107296.1
XP_030107297.1
XP_030107298.1
XP_030107299.1
XP_030107300.1
XP_030107302.1
XP_030107304.1
XP_030107306.1
XP_030107307.1
XP_030107308.1
XP_030107309.1
XP_030107310.1
XP_030107311.1
XP_030107312.1
XP_030107314.1
XP_030107315.1
XP_030107316.1
XP_030107317.1
XP_030107318.1
XP_036017951.1
XP_036017952.1
XP_036017953.1
XP_036017954.1
XP_036017955.1
XP_036017956.1
XP_036017957.1
XP_036017958.1
XP_036017959.1
XP_036017960.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021523.5 → NP_067498.4  E3 ubiquitin-protein ligase HUWE1

    See identical proteins and their annotated locations for NP_067498.4

    Status: VALIDATED

    Source sequence(s)
    AL672180, AL954855, BX571795
    Consensus CDS
    CCDS41176.1
    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    UniProtKB/TrEMBL
    A2AFQ0
    Related
    ENSMUSP00000026292.9, ENSMUST00000026292.15
    Conserved Domains (7) summary
    cd00078
    Location:4023 → 4376
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1317 → 1356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1617 → 1678
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3011 → 3042
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2731 → 2914
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    150583779..150718413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162059.1 → XP_036017952.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  2. XM_030251448.1 → XP_030107308.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  3. XM_030251434.1 → XP_030107294.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  4. XM_030251447.1 → XP_030107307.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (6) summary
    cd00078
    Location:4086 → 4439
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  5. XM_036162060.1 → XP_036017953.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4068 → 4421
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3056 → 3087
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2776 → 2959
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  6. XM_030251458.1 → XP_030107318.1  E3 ubiquitin-protein ligase HUWE1 isoform X9

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (6) summary
    cd00078
    Location:3967 → 4320
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2955 → 2988
    DUF4414; Domain of unknown function (DUF4414)

  7. XM_030251444.1 → XP_030107304.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (6) summary
    cd00078
    Location:4099 → 4452
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3087 → 3120
    DUF4414; Domain of unknown function (DUF4414)

  8. XM_030251446.1 → XP_030107306.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (6) summary
    cd00078
    Location:4092 → 4445
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1386 → 1425
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1686 → 1747
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3080 → 3113
    DUF4414; Domain of unknown function (DUF4414)

  9. XM_030251457.1 → XP_030107317.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4014 → 4367
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1308 → 1347
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1608 → 1669
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3002 → 3033
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2722 → 2905
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  10. XM_030251435.1 → XP_030107295.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  11. XM_006528934.3 → XP_006528997.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006528997.1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  12. XM_036162063.1 → XP_036017956.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  13. XM_006528938.3 → XP_006529001.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006529001.1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  14. XM_030251449.1 → XP_030107309.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  15. XM_006528939.3 → XP_006529002.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006529002.1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  16. XM_006528936.3 → XP_006528999.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006528999.1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  17. XM_036162061.1 → XP_036017954.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  18. XM_030251436.1 → XP_030107296.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  19. XM_036162062.1 → XP_036017955.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  20. XM_006528937.3 → XP_006529000.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006529000.1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  21. XM_030251455.1 → XP_030107315.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    UniProtKB/TrEMBL
    A2AFQ0
    Conserved Domains (7) summary
    cd00078
    Location:4023 → 4376
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1317 → 1356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1617 → 1678
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3011 → 3042
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2731 → 2914
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  22. XM_036162064.1 → XP_036017957.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  23. XM_006528940.3 → XP_006529003.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006529003.1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  24. XM_036162066.1 → XP_036017959.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    UniProtKB/TrEMBL
    A2AFQ0
    Conserved Domains (7) summary
    cd00078
    Location:4023 → 4376
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1317 → 1356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1617 → 1678
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3011 → 3042
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2731 → 2914
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  25. XM_006528948.3 → XP_006529011.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  26. XM_006528951.3 → XP_006529014.1  E3 ubiquitin-protein ligase HUWE1 isoform X10

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (6) summary
    cd00078
    Location:3949 → 4302
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1243 → 1282
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1543 → 1604
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:356 → 740
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2937 → 2970
    DUF4414; Domain of unknown function (DUF4414)

  27. XM_006528933.3 → XP_006528996.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006528996.1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  28. XM_006528949.4 → XP_006529012.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    See identical proteins and their annotated locations for XP_006529012.1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    UniProtKB/TrEMBL
    A2AFQ0
    Conserved Domains (7) summary
    cd00078
    Location:4023 → 4376
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1317 → 1356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1617 → 1678
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3011 → 3042
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2731 → 2914
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  29. XM_030251450.1 → XP_030107310.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  30. XM_011247852.2 → XP_011246154.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_011246154.1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  31. XM_030251451.1 → XP_030107311.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  32. XM_030251437.1 → XP_030107297.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  33. XM_030251452.1 → XP_030107312.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  34. XM_006528943.3 → XP_006529006.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006529006.1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  35. XM_030251456.1 → XP_030107316.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    UniProtKB/TrEMBL
    A2AFQ0
    Conserved Domains (7) summary
    cd00078
    Location:4023 → 4376
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1317 → 1356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1617 → 1678
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3011 → 3042
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2731 → 2914
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  36. XM_036162067.1 → XP_036017960.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4014 → 4367
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1308 → 1347
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1608 → 1669
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3002 → 3033
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2722 → 2905
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  37. XM_030251454.1 → XP_030107314.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  38. XM_030251442.2 → XP_030107302.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  39. XM_030251439.1 → XP_030107299.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  40. XM_036162065.1 → XP_036017958.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4027 → 4380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1321 → 1360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1621 → 1682
    WWE; WWE domain
    pfam06012
    Location:18 → 293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357 → 818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3015 → 3046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2735 → 2918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  41. XM_030251438.1 → XP_030107298.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  42. XM_030251440.1 → XP_030107300.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  43. XM_036162058.1 → XP_036017951.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/Swiss-Prot
    A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
    Conserved Domains (7) summary
    cd00078
    Location:4101 → 4454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1395 → 1434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1695 → 1756
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3089 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:2809 → 2992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMY8.5 GenPept UniProtKB/Swiss-Prot:Q7TMY8

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