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Grk5 G protein-coupled receptor kinase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59075, updated on 2-Nov-2024

Summary

Official Symbol
Grk5provided by RGD
Official Full Name
G protein-coupled receptor kinase 5provided by RGD
Primary source
RGD:61985
See related
EnsemblRapid:ENSRNOG00000011439 AllianceGenome:RGD:61985
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gprk5
Summary
Predicted to enable beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity. Involved in negative regulation of G protein-coupled receptor signaling pathway; oligodendrocyte differentiation; and response to cocaine. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be active in cytoplasm. Biomarker of Parkinson's disease and hypertension. Orthologous to human GRK5 (G protein-coupled receptor kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 258.1), Heart (RPKM 102.4) and 9 other tissues See more
Orthologs
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Genomic context

See Grk5 in Genome Data Viewer
Location:
1q55
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (270014314..270208294)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (260028269..260223699)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (282265371..282467842)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sideroflexin 4 Neighboring gene uncharacterized LOC134485269 Neighboring gene peroxiredoxin 3 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene RNA, U6 small nuclear 28 Neighboring gene zinc finger protein 950 Neighboring gene zinc finger protein 933

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC93405

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor kinase activity IC
Inferred by Curator
more info
PubMed 
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables beta-adrenergic receptor kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oligodendrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in tachykinin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
G protein-coupled receptor kinase 5
Names
g protein-coupled receptor kinase GRK5
NP_110456.2
XP_038944728.1
XP_038944729.1
XP_038944734.1
XP_038944738.1
XP_038944748.1
XP_038944755.1
XP_038944756.1
XP_063128278.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030829.2NP_110456.2  G protein-coupled receptor kinase 5

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q62833
    UniProtKB/TrEMBL
    A6JIB2, F7EZU6, Q66HL7
    Related
    ENSRNOP00000015687.4, ENSRNOT00000015687.8
    Conserved Domains (2) summary
    cd05632
    Location:183495
    STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
    cl02565
    Location:53175
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    270014314..270208294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088820.2XP_038944748.1  G protein-coupled receptor kinase 5 isoform X5

    UniProtKB/Swiss-Prot
    Q62833
    Conserved Domains (2) summary
    cd05605
    Location:235472
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:74225
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. XM_039088800.2XP_038944728.1  G protein-coupled receptor kinase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q62833
    Conserved Domains (2) summary
    cd05632
    Location:233545
    STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
    cl02565
    Location:74225
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. XM_039088827.2XP_038944755.1  G protein-coupled receptor kinase 5 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZX64
    Conserved Domains (2) summary
    cd05632
    Location:180492
    STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
    cl02565
    Location:21172
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  4. XM_039088810.2XP_038944738.1  G protein-coupled receptor kinase 5 isoform X4

    UniProtKB/Swiss-Prot
    Q62833
    Conserved Domains (2) summary
    cd05632
    Location:204516
    STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
    cl02565
    Location:74196
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  5. XM_039088806.2XP_038944734.1  G protein-coupled receptor kinase 5 isoform X3

    UniProtKB/Swiss-Prot
    Q62833
    Related
    ENSRNOP00000104808.1, ENSRNOT00000139040.1
    Conserved Domains (2) summary
    cd05632
    Location:212524
    STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
    cl02565
    Location:53204
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  6. XM_039088801.2XP_038944729.1  G protein-coupled receptor kinase 5 isoform X2

    UniProtKB/Swiss-Prot
    Q62833
    Conserved Domains (2) summary
    cd05632
    Location:225537
    STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
    cl02565
    Location:66217
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  7. XM_063272208.1XP_063128278.1  G protein-coupled receptor kinase 5 isoform X8

  8. XM_039088828.2XP_038944756.1  G protein-coupled receptor kinase 5 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:4300
    PKc_like; Protein Kinases, catalytic domain