U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fxyd6 FXYD domain-containing ion transport regulator 6 [ Mus musculus (house mouse) ]

Gene ID: 59095, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Fxyd6provided by MGI
Official Full Name
FXYD domain-containing ion transport regulator 6provided by MGI
Primary source
MGI:MGI:1890226
See related
Ensembl:ENSMUSG00000066705 AllianceGenome:MGI:1890226
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Php; 0610030I18Rik
Summary
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, Fxyd6, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Jul 2006]
Expression
Broad expression in CNS E18 (RPKM 180.7), whole brain E14.5 (RPKM 104.7) and 19 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fxyd6 in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45280768..45307457)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45369470..45396159)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene interleukin 10 receptor, alpha Neighboring gene microRNA 7086 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45108641-45108750 Neighboring gene brown adipose tissue enriched long noncoding RNA 3 Neighboring gene transmembrane protease, serine 13 Neighboring gene STARR-seq mESC enhancer starr_23995 Neighboring gene RIKEN cDNA 4833428L15 gene Neighboring gene predicted gene, 57798 Neighboring gene STARR-seq mESC enhancer starr_24004 Neighboring gene FXYD domain-containing ion transport regulator 2 Neighboring gene DS cell adhesion molecule like 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. FXYD6 is a novel regulator of Na,K-ATPase expressed in the inner ear. Delprat B, et al. J Biol Chem, 2007 Mar 9. PMID 17209044
  2. FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells. Shindo Y, et al. Biosci Biotechnol Biochem, 2011. PMID 21670532
  3. Molecular cloning and characterization of a novel phospholemman-like protein from rat hippocampus. Yamaguchi F, et al. Brain Res Mol Brain Res, 2001 Jan 31. PMID 11165386
  4. FXYD proteins: new regulators of Na-K-ATPase. Geering K. Am J Physiol Renal Physiol, 2006 Feb. PMID 16403837
  5. Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins. Pereira Luppi M, et al. Cell Rep, 2021 Nov 9. PMID 34758317, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ion channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in presynaptic membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
FXYD domain-containing ion transport regulator 6
Names
PLM-like protein
phosphohippolin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022004.6 → NP_071287.1  FXYD domain-containing ion transport regulator 6 precursor

    See identical proteins and their annotated locations for NP_071287.1

    Status: REVIEWED

    Source sequence(s)
    AK003888, BG093642, BQ891313, BY081454
    Consensus CDS
    CCDS23133.1
    UniProtKB/Swiss-Prot
    Q99NC3, Q9CXD0, Q9D164
    Related
    ENSMUSP00000083101.7, ENSMUST00000085939.8
    Conserved Domains (1) summary
    cl40453
    Location:2 → 93
    FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45280768..45307457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244486.1 → XP_030100346.1  FXYD domain-containing ion transport regulator 6 isoform X1

    Conserved Domains (1) summary
    pfam02038
    Location:178 → 223
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

  2. XM_036155163.1 → XP_036011056.1  FXYD domain-containing ion transport regulator 6 isoform X2

    UniProtKB/Swiss-Prot
    Q99NC3, Q9CXD0, Q9D164
    Conserved Domains (1) summary
    cl40453
    Location:2 → 93
    FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family

  3. XM_036155164.1 → XP_036011057.1  FXYD domain-containing ion transport regulator 6 isoform X2

    UniProtKB/Swiss-Prot
    Q99NC3, Q9CXD0, Q9D164
    Conserved Domains (1) summary
    cl40453
    Location:2 → 93
    FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D164.2 GenPept UniProtKB/Swiss-Prot:Q9D164

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous