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Rgs19 regulator of G-protein signaling 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59293, updated on 2-Nov-2024

Summary

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Official Symbol
Rgs19provided by RGD
Official Full Name
regulator of G-protein signaling 19provided by RGD
Primary source
RGD:629471
See related
EnsemblRapid:ENSRNOG00000016547 AllianceGenome:RGD:629471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gaip; Camki
Summary
Enables G-protein alpha-subunit binding activity. Involved in response to ethanol. Located in brush border and clathrin-coated vesicle. Orthologous to human RGS19 (regulator of G protein signaling 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 46.3), Thymus (RPKM 45.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rgs19 in Genome Data Viewer
Location:
3q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (189182041..189190494, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168804532..168813035, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177196276..177204767, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101835 Neighboring gene transcription elongation factor A2 Neighboring gene LKAAEAR motif containing 1 Neighboring gene opioid related nociceptin receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles. De Vries L, et al. Mol Biol Cell, 1998 May. PMID 9571244, Free PMC Article
  2. Chronic intermittent ethanol exposure selectively alters the expression of Gα subunit isoforms and RGS subtypes in rat prefrontal cortex. Luessen DJ, et al. Brain Res, 2017 Oct 1. PMID 28736108, Free PMC Article
  3. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Serezani CH, et al. Blood, 2009 Oct 8. PMID 19657115, Free PMC Article
  4. Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles. Fischer T, et al. Proc Natl Acad Sci U S A, 2000 Apr 11. PMID 10760275, Free PMC Article
  5. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. Lou X, et al. J Am Soc Nephrol, 2002 Apr. PMID 11912251

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC108699

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables GTPase activator activity TAS
Traceable Author Statement
more info
 PubMed 
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to interleukin-7 ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glutamate secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 19
Names
G alpha interacting protein
calcium/calmodulin-dependent protein kinase I
regulator of G-protein signalling 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429113.1 → NP_001416042.1  regulator of G-protein signaling 19

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    O70521
    UniProtKB/TrEMBL
    A6KLX5

  2. NM_021661.3 → NP_067693.1  regulator of G-protein signaling 19

    See identical proteins and their annotated locations for NP_067693.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    O70521
    UniProtKB/TrEMBL
    A6KLX5
    Related
    ENSRNOP00000022451.4, ENSRNOT00000022451.6
    Conserved Domains (1) summary
    cl02565
    Location:87 → 204
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RNA

  1. NR_190577.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    189182041..189190494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284434.1 → XP_063140504.1  regulator of G-protein signaling 19 isoform X3

  2. XM_006235801.5 → XP_006235863.3  regulator of G-protein signaling 19 isoform X1

  3. XM_008762541.4 → XP_008760763.1  regulator of G-protein signaling 19 isoform X4

    See identical proteins and their annotated locations for XP_008760763.1

    UniProtKB/TrEMBL
    A6KLX9
    Related
    ENSRNOP00000099010.1, ENSRNOT00000174086.1
    Conserved Domains (1) summary
    cl02565
    Location:65 → 182
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  4. XM_008762540.4 → XP_008760762.1  regulator of G-protein signaling 19 isoform X4

    See identical proteins and their annotated locations for XP_008760762.1

    UniProtKB/TrEMBL
    A6KLX9
    Conserved Domains (1) summary
    cl02565
    Location:65 → 182
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  5. XM_063284433.1 → XP_063140503.1  regulator of G-protein signaling 19 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70521.1 GenPept UniProtKB/Swiss-Prot:O70521

Gene LinkOut

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