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Tmem33 transmembrane protein 33 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59303, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem33provided by RGD
Official Full Name
transmembrane protein 33provided by RGD
Primary source
RGD:708371
See related
EnsemblRapid:ENSRNOG00000002254 AllianceGenome:RGD:708371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including endoplasmic reticulum tubular network organization; positive regulation of endoplasmic reticulum unfolded protein response; and regulation of endoplasmic reticulum tubular network organization. Predicted to be located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Predicted to be active in endoplasmic reticulum. Orthologous to human TMEM33 (transmembrane protein 33). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 331.4), Liver (RPKM 283.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem33 in Genome Data Viewer
Location:
14p11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (41242358..41264586, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (40888485..40910715, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (42537352..42559580, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene solute carrier family 30 member 9 Neighboring gene uncharacterized LOC134481844 Neighboring gene uncharacterized LOC134481845

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of a novel rat gene, DB83, that encodes a putative membrane protein. Nakadai T, et al. DNA Res, 1998 Oct 30. PMID 9872456
  2. TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling. Sakabe I, et al. Breast Cancer Res Treat, 2015 Sep. PMID 26268696, Free PMC Article
  3. Identification and characterization of TMEM33 as a reticulon-binding protein. Urade T, et al. Kobe J Med Sci, 2014 Nov 6. PMID 25612671
  4. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. Chi A, et al. J Proteome Res, 2006 Nov. PMID 17081065
  5. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Wang X, et al. Cell, 2006 Nov 17. PMID 17110338

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of IRE1-mediated unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of PERK-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of PERK-mediated unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endoplasmic reticulum tubular network organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in melanosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 33
Names
db83

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034198.2 → NP_001029370.1  transmembrane protein 33 isoform 2

    See identical proteins and their annotated locations for NP_001029370.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0H2UHA6, A6JDA6, A6JDA8
    Related
    ENSRNOP00000003128.4, ENSRNOT00000003128.6
    Conserved Domains (1) summary
    pfam03661
    Location:9 → 245
    UPF0121; Uncharacterized protein family (UPF0121)

  2. NM_021671.5 → NP_067703.1  transmembrane protein 33 isoform 1

    See identical proteins and their annotated locations for NP_067703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q9Z142
    UniProtKB/TrEMBL
    A6JDA7, A6JDA8
    Related
    ENSRNOP00000097007.1, ENSRNOT00000110302.2
    Conserved Domains (1) summary
    pfam03661
    Location:9 → 245
    UPF0121; Uncharacterized protein family (UPF0121)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    41242358..41264586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z142.1 GenPept UniProtKB/Swiss-Prot:Q9Z142

Gene LinkOut

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