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RBMS2 RNA binding motif single stranded interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 5939, updated on 3-Nov-2024

Summary

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Official Symbol
RBMS2provided by HGNC
Official Full Name
RNA binding motif single stranded interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:9909
See related
Ensembl:ENSG00000076067 MIM:602387; AllianceGenome:HGNC:9909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCR3
Summary
The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 17.5), placenta (RPKM 15.2) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See RBMS2 in Genome Data Viewer
Location:
12q13.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56520405..56596193)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56488069..56564187)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56915604..56989977)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4559 Neighboring gene glutaminase 2 Neighboring gene small nucleolar RNA, H/ACA box 105C Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56916039-56916782 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56959127-56959665 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56959666-56960203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6503 Neighboring gene RNA, U6 small nuclear 343, pseudogene Neighboring gene bromodomain adjacent to zinc finger domain 2A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:57020987-57021488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:57029126-57029638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6509 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:57030665-57031176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:57038866-57039576 Neighboring gene ATP synthase F1 subunit beta Neighboring gene small nucleolar RNA, C/D box 59B Neighboring gene small nucleolar RNA, C/D box 59A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes. Skerka C, et al. J Immunol, 1992 May 15. PMID 1533657
  2. SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. Kanaoka Y, et al. Nucleic Acids Res, 1994 Jul 11. PMID 8041632, Free PMC Article
  3. RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer. Sun X, et al. J Exp Clin Cancer Res, 2018 Dec 4. PMID 30514345, Free PMC Article
  4. Identification of long stress-induced non-coding transcripts that have altered expression in cancer. Silva JM, et al. Genomics, 2010 Jun. PMID 20214974
  5. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Dastani Z, et al. PLoS Genet, 2012. PMID 22479202, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39093, FLJ40023, FLJ43262

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA processing TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding motif, single-stranded-interacting protein 2
Names
suppressor of CDC2 with RNA-binding motif 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414459.1 → NP_001401388.1  RNA-binding motif, single-stranded-interacting protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC090681, AC097104

  2. NM_001414460.1 → NP_001401389.1  RNA-binding motif, single-stranded-interacting protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC090681, AC097104

  3. NM_001414461.1 → NP_001401390.1  RNA-binding motif, single-stranded-interacting protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC090681, AC097104
    UniProtKB/Swiss-Prot
    Q15434

  4. NM_002898.4 → NP_002889.1  RNA-binding motif, single-stranded-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_002889.1

    Status: REVIEWED

    Source sequence(s)
    AC090681, AC097104, BC027863, CF890834, DC382164
    Consensus CDS
    CCDS8923.1
    UniProtKB/Swiss-Prot
    Q15434
    UniProtKB/TrEMBL
    F8W1T6
    Related
    ENSP00000262031.5, ENST00000262031.10
    Conserved Domains (2) summary
    cd12474
    Location:135 → 220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:49 → 134
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56520405..56596193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449115.2 → XP_024304883.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

    Conserved Domains (2) summary
    cd12470
    Location:19 → 104
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:105 → 190
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  2. XM_005269059.6 → XP_005269116.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X3

    Conserved Domains (2) summary
    cd12470
    Location:49 → 134
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:135 → 220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  3. XM_011538639.3 → XP_011536941.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X8

    Conserved Domains (2) summary
    cd12474
    Location:135 → 220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:49 → 134
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_005269060.6 → XP_005269117.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X7

    Conserved Domains (2) summary
    cd12470
    Location:49 → 134
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:135 → 220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  5. XM_047429297.1 → XP_047285253.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

  6. XM_006719541.5 → XP_006719604.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

    Conserved Domains (2) summary
    cd12470
    Location:49 → 134
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:135 → 220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  7. XM_006719542.5 → XP_006719605.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X4

    Conserved Domains (2) summary
    cd12470
    Location:49 → 134
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:135 → 220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  8. XM_005269066.5 → XP_005269123.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X10

    Conserved Domains (1) summary
    cl17169
    Location:49 → 134
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. XM_024449116.2 → XP_024304884.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

    Conserved Domains (2) summary
    cd12470
    Location:19 → 104
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:105 → 190
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  10. XM_047429298.1 → XP_047285254.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X6

  11. XM_011538642.4 → XP_011536944.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X9

    See identical proteins and their annotated locations for XP_011536944.1

    Conserved Domains (1) summary
    cd12474
    Location:10 → 95
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56488069..56564187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372813.1 → XP_054228788.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

  2. XM_054372811.1 → XP_054228786.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X3

  3. XM_054372817.1 → XP_054228792.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X8

  4. XM_054372816.1 → XP_054228791.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X7

  5. XM_054372810.1 → XP_054228785.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

  6. XM_054372809.1 → XP_054228784.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

  7. XM_054372812.1 → XP_054228787.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X4

  8. XM_054372819.1 → XP_054228794.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X10

  9. XM_054372814.1 → XP_054228789.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

  10. XM_054372815.1 → XP_054228790.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X6

  11. XM_054372818.1 → XP_054228793.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15434.1 GenPept UniProtKB/Swiss-Prot:Q15434

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