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RGS4 regulator of G protein signaling 4 [ Homo sapiens (human) ]

Gene ID: 5999, updated on 2-Nov-2024

Summary

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Official Symbol
RGS4provided by HGNC
Official Full Name
regulator of G protein signaling 4provided by HGNC
Primary source
HGNC:HGNC:10000
See related
Ensembl:ENSG00000117152 MIM:602516; AllianceGenome:HGNC:10000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGP4; SCZD9
Summary
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 67.5), adrenal (RPKM 15.7) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See RGS4 in Genome Data Viewer
Location:
1q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (163068871..163076802)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (162413422..162421357)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (163038661..163046592)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial-like Neighboring gene NANOG hESC enhancer GRCh37_chr1:162971378-162971879 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:163005147-163006346 Neighboring gene uncharacterized LOC107985223 Neighboring gene uncharacterized LOC124904446 Neighboring gene RGS4-RGS5 intergenic ENCODE-defined enhancer Neighboring gene NANOG hESC enhancer GRCh37_chr1:163101622-163102196 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_592 Neighboring gene regulator of G protein signaling 5 Neighboring gene RGS5 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:163172770-163173435 Neighboring gene TRNT1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population. So HC, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Jan 5. PMID 17722013
  2. Evaluation of RGS4 as a candidate gene for schizophrenia. Liu YL, et al. Am J Med Genet B Neuropsychiatr Genet, 2006 Jun 5. PMID 16526029
  3. RGS4 genotype is not associated with antipsychotic medication response in schizophrenia. Kampman O, et al. J Neural Transm (Vienna), 2006 Oct. PMID 16604300
  4. Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. Talkowski ME, et al. Biol Psychiatry, 2006 Jul 15. PMID 16631129, Free PMC Article
  5. Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4). Levitt P, et al. Biol Psychiatry, 2006 Sep 15. PMID 16860780

See all (141) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms.
    Title: RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms.
  2. Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4.
    Title: Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4.
  3. Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia.
    Title: Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia.
  4. Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling.
    Title: Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling.
  5. RGS4 controls Galphai3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes.
    Title: RGS4 controls Gαi3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes.
  6. miR-874-3p inhibits cell migration through targeting RGS4 in osteosarcoma.
    Title: miR-874-3p inhibits cell migration through targeting RGS4 in osteosarcoma.
  7. Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Galpha in live cells.
    Title: Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Gα in live cells.
  8. RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis.
    Title: RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis.
  9. Targeting RGS4 Ablates Glioblastoma Proliferation.
    Title: Targeting RGS4 Ablates Glioblastoma Proliferation.
  10. lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer.
    Title: lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer.
Submit: New GeneRIF Correction See all GeneRIFs (85)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of regulator of G-protein signaling 4 (RGS4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2124, MGC60244, DKFZp761F1924

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
  
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in dorsal root ganglion development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glycine import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of actin filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to amphetamine IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cocaine IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 4
Names
schizophrenia disorder 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023312.1 RefSeqGene

    Range
    5756..13197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001102445.3 → NP_001095915.1  regulator of G-protein signaling 4 isoform 1

    See identical proteins and their annotated locations for NP_001095915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL583850, DQ346664
    Consensus CDS
    CCDS44270.1
    UniProtKB/Swiss-Prot
    P49798
    Related
    ENSP00000397181.2, ENST00000421743.6
    Conserved Domains (1) summary
    cd08714
    Location:160 → 273
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

  2. NM_001113380.1 → NP_001106851.1  regulator of G-protein signaling 4 isoform 3

    See identical proteins and their annotated locations for NP_001106851.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two 5' exons but has an alternate 5' UTR exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL583850, EF054877
    Consensus CDS
    CCDS44272.1
    UniProtKB/Swiss-Prot
    P49798
    Related
    ENSP00000356882.3, ENST00000367906.7
    Conserved Domains (1) summary
    cd08714
    Location:45 → 158
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

  3. NM_001113381.1 → NP_001106852.1  regulator of G-protein signaling 4 isoform 4

    See identical proteins and their annotated locations for NP_001106852.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' sequence, which results in a downstream AUG start codon, and lacks an internal coding exon in the 3' region, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK093959, AL583850, DA660695
    Consensus CDS
    CCDS44271.1
    UniProtKB/Swiss-Prot
    P49798
    Related
    ENSP00000356884.4, ENST00000367908.8

  4. NM_005613.6 → NP_005604.1  regulator of G-protein signaling 4 isoform 2

    See identical proteins and their annotated locations for NP_005604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL583850, DQ346663
    Consensus CDS
    CCDS1243.1
    UniProtKB/Swiss-Prot
    A7XA56, A7XA58, A7XA59, A7YVV7, B1APZ3, P49798
    Related
    ENSP00000356885.6, ENST00000367909.11
    Conserved Domains (1) summary
    cd08714
    Location:63 → 176
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    163068871..163076802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    162413422..162421357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49798.1 GenPept UniProtKB/Swiss-Prot:P49798

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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