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Ensa endosulfine alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 60334, updated on 17-Aug-2024

Summary

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Official Symbol
Ensaprovided by RGD
Official Full Name
endosulfine alphaprovided by RGD
Primary source
RGD:62007
See related
EnsemblRapid:ENSRNOG00000048617 AllianceGenome:RGD:62007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including potassium channel inhibitor activity; protein phosphatase 2A binding activity; and protein phosphatase inhibitor activity. Involved in response to glucose. Located in cytoplasm. Orthologous to human ENSA (endosulfine alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 459.1), Muscle (RPKM 435.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185874500..185881838)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183185552..183192888)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (197752544..197759882)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene HORMA domain containing 1 Neighboring gene transfer RNA leucine (anticodon AAG) 16 Neighboring gene golgi phosphoprotein 3-like Neighboring gene RNA, U6 small nuclear 857 Neighboring gene MCL1 apoptosis regulator, BCL2 family member Neighboring gene ADAMTS-like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. α-Endosulfine (ARPP-19e) Expression in a Rat Model of Stroke. Mehta RI, et al. J Neuropathol Exp Neurol, 2017 Oct 1. PMID 28922851, Free PMC Article
  2. Rat mesangial alpha-endosulfine. Yee J, et al. Kidney Int, 2004 May. PMID 15086912
  3. Gene expression of alpha-endosulfine in the rat brain: correlative changes with aging, learning and stress. Dou J, et al. J Neurochem, 2003 Dec. PMID 14622089
  4. Localization of alpha-endosulphine in pancreatic somatostatin delta cells and expression during rat pancreas development. Gros L, et al. Diabetologia, 2002 May. PMID 12107751
  5. cDNA microarray analysis of spinal cord injury and regeneration related genes in rat. Xiao L, et al. Sheng Li Xue Bao, 2005 Dec 25. PMID 16344894

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that the alphaEnsa levels are significantly upregulated in mammalian brain at various times following the onset of ischemia/reperfusion. Protein upregulation was detected as early as 2 hours after ischemic onset, with sustained upregulation noted subsequently over several days
    Title: α-Endosulfine (ARPP-19e) Expression in a Rat Model of Stroke.
  2. localization in pancreatic somatostatin delta cells and expression during rat pancreas development
    Title: Localization of alpha-endosulphine in pancreatic somatostatin delta cells and expression during rat pancreas development.
  3. results suggest that alpha-endosulfine gene expression is differentially regulated by distinct brain processes involving excitatory neuronal activities
    Title: Gene expression of alpha-endosulfine in the rat brain: correlative changes with aging, learning and stress.
  4. ENSA and alpha-endosulfine are expressed in glomeruli and mesangial cells, and gene and protein expression are up-regulated by a high glucose environment.
    Title: Rat mesangial alpha-endosulfine.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables potassium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein phosphatase 2A binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucose IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-endosulfine
Names
ARPP-19e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033974.2 → NP_001029146.1  alpha-endosulfine isoform 1

    See identical proteins and their annotated locations for NP_001029146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    BC059135, JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6G7F4, A6K303
    Related
    ENSRNOP00000083613.1, ENSRNOT00000104132.2
    Conserved Domains (1) summary
    pfam04667
    Location:33 → 86
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  2. NM_021842.3 → NP_068614.1  alpha-endosulfine isoform 2

    See identical proteins and their annotated locations for NP_068614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and a different 3' terminal exon compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    CB812628, JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P60841, Q6PCU7
    UniProtKB/TrEMBL
    A0A8I6G7F4, A6K302
    Related
    ENSRNOP00000063946.1, ENSRNOT00000075511.4
    Conserved Domains (1) summary
    pfam04667
    Location:33 → 86
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185874500..185881838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60841.1 GenPept UniProtKB/Swiss-Prot:P60841

Gene LinkOut

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