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Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60341, updated on 14-Nov-2024

Summary

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Official Symbol
Camkk1provided by RGD
Official Full Name
calcium/calmodulin-dependent protein kinase kinase 1provided by RGD
Primary source
RGD:62023
See related
EnsemblRapid:ENSRNOG00000018242 AllianceGenome:RGD:62023
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Involved in activation of protein kinase activity. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 166.6), Lung (RPKM 59.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Camkk1 in Genome Data Viewer
Location:
10q24
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58135872..58159023)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57637335..57660498)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59585023..59608180)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Neighboring gene purinergic receptor P2X 1 Neighboring gene nuclear cap binding subunit 3 Neighboring gene integrin subunit alpha E Neighboring gene histone H3 associated protein kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evidence for the existence of Ca2+/calmodulin-dependent protein kinase IV kinase isoforms in rat brain. Okuno S, et al. J Biochem, 1996 Jun. PMID 8827455
  2. Distribution of Ca2+/calmodulin-dependent protein kinase kinase alpha in the rat central nervous system: an immunohistochemical study. Nakamura Y, et al. Neurosci Lett, 1996 Feb 2. PMID 8929978
  3. Inhibitory cross-talk by cAMP kinase on the calmodulin-dependent protein kinase cascade. Wayman GA, et al. J Biol Chem, 1997 Jun 27. PMID 9195898
  4. Calcium/calmodulin-dependent protein kinase kinase: identification of regulatory domains. Tokumitsu H, et al. Biochemistry, 1997 Oct 21. PMID 9335539
  5. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Yano S, et al. Nature, 1998 Dec 10. PMID 9859994

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oligomerization of Ca(2+)/calmodulin-dependent protein kinase kinase.
    Title: Oligomerization of Ca(2+)/calmodulin-dependent protein kinase kinase.
  2. Ghrelin inhibited pressure overload-induced cardiac hypertrophy by promoting autophagy via CaMKK/AMPK signaling pathway.
    Title: Ghrelin inhibited pressure overload-induced cardiac hypertrophy by promoting autophagy via CaMKK/AMPK signaling pathway.
  3. Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK but not of CaMKIalpha.
    Title: Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms.
  4. CaMKKalpha and CaMKKbeta are capable of phosphorylating and activating CaMKIV in living cells.
    Title: Analysis of Distinct Roles of CaMKK Isoforms Using STO-609-Resistant Mutants in Living Cells.
  5. CaMKII(alpha) expression levels in hippocampus of chronic epileptic rats may be related with their impaired spatial learning and memory.
    Title: Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats.
  6. 14-3-3 proteins directly regulate CaMKKalpha when the enzyme is phosphorylated by protein kinase A on either Ser74 or Ser475.
    Title: 14-3-3 Proteins directly regulate Ca(2+)/calmodulin-dependent protein kinase kinase alpha through phosphorylation-dependent multisite binding.
  7. Thr196 phosphorylation of CaM-KIV by CaM-KK reduces interaction of the catalytic core with the autoinhibitory region, resulting in generation of the autonomous activity
    Title: Mechanism of the generation of autonomous activity of Ca2+/calmodulin-dependent protein kinase IV.
  8. ERK activation and neurite outgrowth in response to depolarization are mediated by CaMKK activation of CaMKI
    Title: Calcium activation of ERK mediated by calmodulin kinase I.
  9. Translocation of CaMKI-alpha into the nucleus involves a conserved sequence located within the catalytic core. Mutation of this sequence partially blocks nuclear entry of an export-impaired mutant of CaMKI-alpha.
    Title: Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-alpha depends on a nuclear export signal in its regulatory domain.
  10. Lkb1 and CaMKKalpha function as Snf1 protein kinase kinases, in a cascade that is highly conserved in mouse and yeast
    Title: Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium/calmodulin-dependent protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase kinase 1
Names
alpha CaMKK
caM-KK 1
caM-KK alpha
caM-kinase IV kinase
caM-kinase kinase 1
caM-kinase kinase alpha
caMKK 1
caMKK alpha
calcium/calmodulin-dependent protein kinase kinase 1, alpha
calcium/calmodulin-dependent protein kinase kinase alpha
NP_113850.1
XP_006246861.1
XP_006246863.1
XP_008766088.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031662.1 → NP_113850.1  calcium/calmodulin-dependent protein kinase kinase 1

    See identical proteins and their annotated locations for NP_113850.1

    Status: PROVISIONAL

    Source sequence(s)
    AB023658
    UniProtKB/Swiss-Prot
    P97756, Q64572, Q794E3
    UniProtKB/TrEMBL
    A0A8I5YBZ4
    Related
    ENSRNOP00000091768.2, ENSRNOT00000106120.2
    Conserved Domains (2) summary
    smart00220
    Location:128 → 409
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:127 → 410
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    58135872..58159023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767866.4 → XP_008766088.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_008766088.1

    UniProtKB/TrEMBL
    A0A8I5YBZ4, A6HGH7
    Related
    ENSRNOP00000076910.2, ENSRNOT00000104077.2
    Conserved Domains (1) summary
    cd14200
    Location:127 → 410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

  2. XM_006246799.5 → XP_006246861.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006246861.1

    UniProtKB/TrEMBL
    A0A8I5YBZ4, A6HGH7
    Conserved Domains (1) summary
    cd14200
    Location:127 → 410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

  3. XM_006246801.5 → XP_006246863.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006246863.1

    UniProtKB/TrEMBL
    A0A8I5YBZ4, A6HGH7
    Conserved Domains (1) summary
    cd14200
    Location:127 → 410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97756.1 GenPept UniProtKB/Swiss-Prot:P97756

Gene LinkOut

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