Prom1 prominin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prom1provided by RGD
Official Full Name: prominin 1provided by RGD
Primary source: RGD:69367
See related: EnsemblRapid:ENSRNOG00000003098 AllianceGenome:RGD:69367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Prom; CD133
Summary: Predicted to enable actinin binding activity; cadherin binding activity; and cholesterol binding activity. Predicted to be involved in several processes, including glomerular epithelial cell differentiation; photoreceptor cell maintenance; and retina morphogenesis in camera-type eye. Predicted to be located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; and photoreceptor outer segment membrane. Predicted to be active in several cellular components, including apical plasma membrane; microvillus; and prominosome. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 250.8), Kidney (RPKM 151.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (71202303..71307008)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (66989545..67094534)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (71532321..71637400)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad?
Title: High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad?
Mitochondria transfer via tunneling nanotubes is an important mechanism by which CD133+ scattered tubular cells eliminate hypoxic tubular cell injury.
Title: Mitochondria transfer via tunneling nanotubes is an important mechanism by which CD133+ scattered tubular cells eliminate hypoxic tubular cell injury.
The here presented data revealed the upregulation of retinal tissue levels and immunoreactivity of VEGFA and prom1 during hyperglycemia that could contribute to the development of diabetic vasculopathy and neuropathy.
Title: Hyperglycemia Alters the Protein Levels of Prominin-1 and VEGFA in the Retina of Albino Rats.
Data suggest that, at fertilization, Prom1 (97-kDa core protein and 147-/120-kDa glycoforms) is located diffusely in apical domain of UECs (uterine epithelial cells); at implantation, Prom1 is concentrated toward APM (apical plasma membrane) with down-regulation of 120-kDa glycoform and up-regulation of 97-kDa core protein.
Title: Prominin-1 glycosylation changes throughout early pregnancy in uterine epithelial cells under the influence of maternal ovarian hormones.
Their potential to differentiate into endothelial or hepatocyte lineages suggests important functions of CD133+ HSC during liver regeneration.
Title: CD133+ hepatic stellate cells are progenitor cells.
After ischemia/reperfusion injury in kidney, the expression rates of CD133 and KIM-1 antigen rise obviously in cortex renis.
Title: [Influence and distribution of CD133 and CD34 antigen expression in proximal tubule epithelial cells during ischemia/reperfusion injury in rats].
We identified novel cell surface markers specific for hepatic progenitor/oval cells. Six are unique for the adult progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp).
Title: Novel hepatic progenitor cell surface markers in the adult rat liver.
Adenovirus-mediated stromal cell-derived- factor-1alpha gene transfer induces cardiac preservation after infarction via angiogenesis of CD133+ stem cells and anti-apoptosis.
Title: Adenovirus-mediated stromal cell-derived- factor-1alpha gene transfer induces cardiac preservation after infarction via angiogenesis of CD133+ stem cells and anti-apoptosis.
prominin-1 is involved in glucose metabolism and may regulate cellular glucose through its effect on cytoskeleton.
Title: Pentaspan membrane glycoprotein, prominin-1, is involved in glucose metabolism and cytoskeleton alteration.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actinin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in camera-type eye photoreceptor cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in camera-type eye photoreceptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glomerular parietal epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in photoreceptor cell maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nephron tubule epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in retina layer formation	ISO Inferred from Sequence Orthology more info
involved_in retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in prominosome	IBA Inferred from Biological aspect of Ancestor more info
located_in prominosome	ISO Inferred from Sequence Orthology more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prominin-1

Names: fudenine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110137.1 → NP_001103607.1 prominin-1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001103607.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AY262731, BI286840, CB780214, EV765242

UniProtKB/TrEMBL

Q7TSL4

Conserved Domains (1) summary

pfam05478
Location:18 → 812

Prominin
NM_021751.2 → NP_068519.2 prominin-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_068519.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF386758, BI286840, CB780214

UniProtKB/TrEMBL

A0A8I5ZQT1, F7FI74, Q91XN5

Conserved Domains (1) summary

pfam05478
Location:18 → 812

Prominin