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S1pr5 sphingosine-1-phosphate receptor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60399, updated on 2-Nov-2024

Summary

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Official Symbol
S1pr5provided by RGD
Official Full Name
sphingosine-1-phosphate receptor 5provided by RGD
Primary source
RGD:620566
See related
EnsemblRapid:ENSRNOG00000020901 AllianceGenome:RGD:620566
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Edg8; Edg-8
Summary
Enables G protein-coupled receptor activity. Involved in regulation of neuron differentiation. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 55.0), Lung (RPKM 18.2) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See S1pr5 in Genome Data Viewer
Location:
8q13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28062841..28068013, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19786676..19791862, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22268635..22273708, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4A Neighboring gene uncharacterized LOC134480144 Neighboring gene Kelch-like ECH-associated protein 1 Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog Neighboring gene cyclin dependent kinase inhibitor 2D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung. Chiyo M, et al. Am J Transplant, 2008 Mar. PMID 18294150
  2. Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS. Terai K, et al. Neuroscience, 2003. PMID 12617946
  3. Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. Glickman M, et al. Mol Cell Neurosci, 1999 Aug. PMID 10532805
  4. Expression of a novel sphingosine 1-phosphate receptor motif protein gene in maturing rat testes. Khalid AM, et al. Biosci Biotechnol Biochem, 2012. PMID 22972346
  5. Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Jolly PS, et al. Blood, 2005 Jun 15. PMID 15741218, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The LOC290876-encoded gene product (EDG-8) has distinct roles in the nucleus during the processes of spermatocyte maturation and spermatid production in meiosis.
    Title: Expression of a novel sphingosine 1-phosphate receptor motif protein gene in maturing rat testes.
  2. These data demonstrate novel roles of S1P(1R,) which include regulating emigration and modulating lymphocyte activation.
    Title: Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung.
  3. Edg8 receptors are preferentially expressed in oligodendrocyte lineage cells including oligodendrocyte progenitor cells and immature oligodendrocytes in rat CNS, and may have important functions in oligodendrocytic maturation and myelination.
    Title: Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS.
  4. The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
    Title: The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
  5. differences between hS1P(5) and rS1P(5) will be an important point to be considered in the development of selective receptor antagonists.
    Title: Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists.
  6. SphK1 has a role in regulating degranulation and motility of rat mast cells by desensitizing S1P receptors
    Title: Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.
  7. Edg8/S1P5 activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival and that these effects depend on the developmental stage of the cell.
    Title: Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sphingosine-1-phosphate receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sphingosine-1-phosphate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sphingosine 1-phosphate receptor 5
Names
NRG-1
S1P receptor 5
S1P receptor Edg-8
S1P5
endothelial differentiation G-protein-coupled receptor 8
endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
nerve growth factor-regulated G-protein-coupled receptor 1
sphingosine 1-phosphate receptor Edg-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021775.2 → NP_068543.2  sphingosine 1-phosphate receptor 5

    See identical proteins and their annotated locations for NP_068543.2

    Status: PROVISIONAL

    Source sequence(s)
    AF115249
    UniProtKB/Swiss-Prot
    Q9JKM5
    Related
    ENSRNOP00000090421.1, ENSRNOT00000098087.2
    Conserved Domains (1) summary
    pfam00001
    Location:53 → 307
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28062841..28068013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242663.5 → XP_006242725.1  sphingosine 1-phosphate receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006242725.1

    UniProtKB/Swiss-Prot
    Q9JKM5, Q9QY79
    UniProtKB/TrEMBL
    A6JNQ5
    Related
    ENSRNOP00000101555.1, ENSRNOT00000155578.1
    Conserved Domains (2) summary
    cd14964
    Location:38 → 64
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:37 → 318
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006242665.5 → XP_006242727.1  sphingosine 1-phosphate receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006242727.1

    UniProtKB/Swiss-Prot
    Q9JKM5, Q9QY79
    UniProtKB/TrEMBL
    A6JNQ5
    Related
    ENSRNOP00000028380.3, ENSRNOT00000028380.7
    Conserved Domains (2) summary
    cd14964
    Location:38 → 64
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:37 → 318
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_006242664.5 → XP_006242726.1  sphingosine 1-phosphate receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006242726.1

    UniProtKB/Swiss-Prot
    Q9JKM5, Q9QY79
    UniProtKB/TrEMBL
    A6JNQ5
    Conserved Domains (2) summary
    cd14964
    Location:38 → 64
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:37 → 318
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKM5.1 GenPept UniProtKB/Swiss-Prot:Q9JKM5

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