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CDH26 cadherin 26 [ Homo sapiens (human) ]

Gene ID: 60437, updated on 11-Apr-2024

Summary

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Official Symbol
CDH26provided by HGNC
Official Full Name
cadherin 26provided by HGNC
Primary source
HGNC:HGNC:15902
See related
Ensembl:ENSG00000124215 MIM:617685; AllianceGenome:HGNC:15902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VR20
Summary
This gene encodes a member of the cadherin protein family. Cadherins are a family of calcium-dependent adhesion molecules that mediate cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization, migration and differentiation. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This protein is expressed in gastrointestinal epithelial cells and may be upregulated during allergic inflammation. This protein interacts with alpha integrins and may also be involved in leukocyte migration and adhesion. [provided by RefSeq, Jan 2017]
Expression
Biased expression in prostate (RPKM 2.7), urinary bladder (RPKM 1.4) and 10 other tissues See more
Orthologs
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Genomic context

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Location:
20q13.33
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (59958423..60035934)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (61742679..61822261)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (58533478..58589584)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene synaptonemal complex protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13091 Neighboring gene Sharpr-MPRA regulatory region 25 Neighboring gene family with sequence similarity 217 member B Neighboring gene protein phosphatase 1 regulatory subunit 3D Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:58529519-58530020 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:58569287-58569819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:58611565-58612066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:58612067-58612566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18193 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:58633003-58633804 Neighboring gene long intergenic non-protein coding RNA 2910 Neighboring gene uncharacterized LOC729296

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation. Wagner R, et al. Pediatr Surg Int, 2021 Jan. PMID 33161446
  2. Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis. Liu T, et al. Laryngoscope, 2023 Jul. PMID 36069256
  3. Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. Caldwell JM, et al. Mucosal Immunol, 2017 Sep. PMID 28051089, Free PMC Article
  4. Association and interaction analyses of eight genes under asthma linkage peaks. Ferreira MA, et al. Allergy, 2009 Nov. PMID 19824886
  5. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. Nollet F, et al. J Mol Biol, 2000 Jun 9. PMID 10835267

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis.
    Title: Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis.
  2. Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation.
    Title: Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation.
  3. this study shows that cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation
    Title: Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
    Title: Association and interaction analyses of eight genes under asthma linkage peaks.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-catenin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delta-catenin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cadherin-like protein 26
Names
cadherin-like 26
cadherin-like protein VR20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348204.2 → NP_001335133.1  cadherin-like protein 26 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) use an alternate exon in the 5' UTR and 5' coding region and lacks a large portion of the 5' coding region, compared to variant a. The encoded isoform (c) has a a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK074477, AL109928, BC062570
    Consensus CDS
    CCDS86964.1
    UniProtKB/Swiss-Prot
    Q8IXH8
    Related
    ENSP00000244049.3, ENST00000244049.7
    Conserved Domains (1) summary
    pfam01049
    Location:46 → 120
    Cadherin_C; Cadherin cytoplasmic region

  2. NM_021810.6 → NP_068582.2  cadherin-like protein 26 isoform b

    See identical proteins and their annotated locations for NP_068582.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) use an alternate exon in the 5' UTR and 5' coding region and lacks a large portion of the 5' coding region, compared to variant a. The encoded isoform (b) has a a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK074477, AL109928
    Consensus CDS
    CCDS13486.1
    UniProtKB/Swiss-Prot
    Q8IXH8
    Related
    ENSP00000310845.7, ENST00000350849.10
    Conserved Domains (1) summary
    pfam01049
    Location:63 → 150
    Cadherin_C; Cadherin cytoplasmic region

  3. NM_177980.4 → NP_817089.1  cadherin-like protein 26 isoform a precursor

    See identical proteins and their annotated locations for NP_817089.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK055202, AK074477, AL109928, DB234033
    Consensus CDS
    CCDS13485.1
    UniProtKB/Swiss-Prot
    A2A2M5, B3KNX3, Q6P5Y6, Q8IXH8, Q8TCH3, Q9BQN4, Q9NRU1
    UniProtKB/TrEMBL
    B9EG96
    Related
    ENSP00000339390.4, ENST00000348616.9
    Conserved Domains (2) summary
    cd11304
    Location:169 → 271
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:726 → 828
    Cadherin_C; Cadherin cytoplasmic region

RNA

  1. NR_145482.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) uses an alternate splice site compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK074477, AL109928, BC143931, DB234033

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    59958423..60035934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528970.4 → XP_011527272.1  cadherin-like protein 26 isoform X1

    Conserved Domains (1) summary
    cd11304
    Location:156 → 245
    Cadherin_repeat; Cadherin tandem repeat domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    61742679..61822261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323793.1 → XP_054179768.1  cadherin-like protein 26 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IXH8.4 GenPept UniProtKB/Swiss-Prot:Q8IXH8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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