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Kcnt1 potassium sodium-activated channel subfamily T member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60444, updated on 2-Nov-2024

Summary

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Official Symbol
Kcnt1provided by RGD
Official Full Name
potassium sodium-activated channel subfamily T member 1provided by RGD
Primary source
RGD:621106
See related
EnsemblRapid:ENSRNOG00000017283 AllianceGenome:RGD:621106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Slack; rSlo2
Summary
Enables chloride-activated potassium channel activity and intracellular sodium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and developmental and epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 118.1), Brain (RPKM 100.3) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kcnt1 in Genome Data Viewer
Location:
3p13
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29081071..29136902)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8682964..8736615)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3310641..3366558)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene lipocalin 9 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 1 Neighboring gene calmodulin regulated spectrin-associated protein 1 Neighboring gene ribosomal protein L8, pseudogene 7 Neighboring gene PIH1 domain containing 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of Sodium- and Chloride-Sensitive Sites in the Slack Channel. Xu J, et al. J Neurosci, 2023 Apr 12. PMID 36898835, Free PMC Article
  2. The Phe932Ile mutation in KCNT1 channels associated with severe epilepsy, delayed myelination and leukoencephalopathy produces a loss-of-function channel phenotype. Evely KM, et al. Neuroscience, 2017 May 20. PMID 28366665, Free PMC Article
  3. Slack sodium-activated potassium channel membrane expression requires p38 mitogen-activated protein kinase phosphorylation. Gururaj S, et al. Neuropharmacology, 2016 Apr. PMID 26721627, Free PMC Article
  4. cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel. Nuwer MO, et al. Neuropharmacology, 2009 Sep. PMID 19540251
  5. The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis. Ruffin VA, et al. Neuroscience, 2008 Jan 24. PMID 18082331, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits.
    Title: Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits.
  2. Identification of Sodium- and Chloride-Sensitive Sites in the Slack Channel.
    Title: Identification of Sodium- and Chloride-Sensitive Sites in the Slack Channel.
  3. Magi-1 bound to sequence like a calcium-activated potassium channel sodium-activated (Slack) potassium channels, demonstrating macrocomplexing with NaV1.8 channels.
    Title: Magi-1 scaffolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and pain.
  4. characterized an analogous mutation in the rat Slack channel and unexpectedly found this mutation to produce a loss-of-function phenotype
    Title: The Phe932Ile mutation in KCNT1 channels associated with severe epilepsy, delayed myelination and leukoencephalopathy produces a loss-of-function channel phenotype.
  5. mRNA of aquaporin 1 was co-expressed in Xenopus oocytes with homomeric or heteromeric Slick and Slack alpha-subunits. Hypotonic or hypertonic buffers caused changes in current. The heteromeric channel had a characteristic graded sensitivity to small and fast changes in cell volume. This the cell volume sensitivity is dependent on the number of volume sensitive Slick alpha-subunits in the tetrameric channels.
    Title: Heteromeric Slick/Slack K+ channels show graded sensitivity to cell volume changes.
  6. Results show that p38 MAPK is an obligate regulator of Slack channel function via the trafficking of channels into the membrane. The present study identifies Slack KNa channels as p38 MAPK substrates.
    Title: Slack sodium-activated potassium channel membrane expression requires p38 mitogen-activated protein kinase phosphorylation.
  7. Slick channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume.
    Title: Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels.
  8. phosphorylation by protein kinase A does not acutely modulate the function and gating activation kinetics of Slack channels
    Title: cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel.
  9. Heteromer formation requires the N-terminal domain of Slack-B, one of the alternative splice variants of the Slack channel.
    Title: The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.
  10. We conclude that Slack and Slick K(Na) channels are required for depolarizing afterpotential of medium diameter rat dorsal root ganglion neurons
    Title: Slack and Slick KNa channels are required for the depolarizing afterpotential of acutely isolated, medium diameter rat dorsal root ganglion neurons.
Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloride-activated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellular sodium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellular sodium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
potassium channel subfamily T member 1
Names
potassium channel subunit (Slack)
potassium channel, sodium-activated subfamily T, member 1
potassium channel, subfamily T, member 1
sequence like a calcium-activated potassium channel subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413123.1 → NP_001400052.1  potassium channel subfamily T member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    Related
    ENSRNOP00000103835.1, ENSRNOT00000130387.1

  2. NM_021853.2 → NP_068625.2  potassium channel subfamily T member 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    Related
    ENSRNOP00000089937.1, ENSRNOT00000104747.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    29081071..29136902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233704.5 → XP_006233766.1  potassium channel subfamily T member 1 isoform X8

    UniProtKB/TrEMBL
    A6JTB4
    Conserved Domains (2) summary
    pfam03493
    Location:450 → 545
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:224 → 297
    Ion_trans_2; Ion channel

  2. XM_008761624.4 → XP_008759846.1  potassium channel subfamily T member 1 isoform X13

    UniProtKB/TrEMBL
    A0A8I6ALJ8, A6JTB4
    Related
    ENSRNOP00000096324.1, ENSRNOT00000110074.2
    Conserved Domains (2) summary
    pfam03493
    Location:464 → 559
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:238 → 311
    Ion_trans_2; Ion channel

  3. XM_006233707.5 → XP_006233769.1  potassium channel subfamily T member 1 isoform X10

    UniProtKB/TrEMBL
    A6JTB4, D3ZNI9
    Related
    ENSRNOP00000058487.3, ENSRNOT00000061773.5
    Conserved Domains (2) summary
    pfam03493
    Location:450 → 545
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:224 → 297
    Ion_trans_2; Ion channel

  4. XM_006233706.5 → XP_006233768.1  potassium channel subfamily T member 1 isoform X9

    UniProtKB/TrEMBL
    A6JTB5
    Conserved Domains (2) summary
    pfam03493
    Location:484 → 579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:258 → 331
    Ion_trans_2; Ion channel

  5. XM_063284465.1 → XP_063140535.1  potassium channel subfamily T member 1 isoform X11

  6. XM_006233698.5 → XP_006233760.1  potassium channel subfamily T member 1 isoform X2

    UniProtKB/Swiss-Prot
    Q5D6C6, Q9Z258
    Conserved Domains (2) summary
    pfam03493
    Location:484 → 579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:258 → 331
    Ion_trans_2; Ion channel

  7. XM_006233697.5 → XP_006233759.1  potassium channel subfamily T member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5D6C6, Q9Z258
    Conserved Domains (2) summary
    pfam03493
    Location:484 → 579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:258 → 331
    Ion_trans_2; Ion channel

  8. XM_006233701.5 → XP_006233763.1  potassium channel subfamily T member 1 isoform X5

    UniProtKB/Swiss-Prot
    Q5D6C6, Q9Z258
    Conserved Domains (2) summary
    pfam03493
    Location:484 → 579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:258 → 331
    Ion_trans_2; Ion channel

  9. XM_006233700.5 → XP_006233762.1  potassium channel subfamily T member 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A9R0
    Conserved Domains (2) summary
    pfam03493
    Location:470 → 565
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:244 → 317
    Ion_trans_2; Ion channel

  10. XM_006233699.5 → XP_006233761.1  potassium channel subfamily T member 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5D6C6, Q9Z258
    UniProtKB/TrEMBL
    F1LSG1
    Related
    ENSRNOP00000023542.6, ENSRNOT00000023542.7
    Conserved Domains (2) summary
    pfam03493
    Location:484 → 579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:258 → 331
    Ion_trans_2; Ion channel

  11. XM_006233703.5 → XP_006233765.1  potassium channel subfamily T member 1 isoform X7

    UniProtKB/Swiss-Prot
    Q5D6C6, Q9Z258
    Conserved Domains (2) summary
    pfam03493
    Location:484 → 579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:258 → 331
    Ion_trans_2; Ion channel

  12. XM_006233702.5 → XP_006233764.1  potassium channel subfamily T member 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A9R0
    Conserved Domains (2) summary
    pfam03493
    Location:470 → 565
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:244 → 317
    Ion_trans_2; Ion channel

  13. XM_039105771.2 → XP_038961699.1  potassium channel subfamily T member 1 isoform X12

    Conserved Domains (1) summary
    pfam03493
    Location:50 → 152
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit

RNA

  1. XR_005501975.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z258.1 GenPept UniProtKB/Swiss-Prot:Q9Z258

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